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Anapharm europe bioanalytical methods 2013 april
LIST OF BIOANALYTICAL METHODS
NEWLY DEVELOPED OR RECENTLY UPDATED METHODS
Bioanalytical
Compound
Calibration Range
Bioanalytical matrix
Carbidopa ; Levodopa
LC/MS/MS
2-75 ng/mL ; 10-750 ng/mL
Human EDTA Plasma
Carbidopa ; Levodopa
LC/MS/MS
5-250 ng/mL ; 10-2500 ng/mL
Human EDTA Plasma
Budesonide
LC/MS/MS
5-1000 pg/mL
Human EDTA Plasma
Formoterol
LC/MS/MS
0.4-100 pg/mL
Human EDTA Plasma
0.2-20 ng/mL; 0.2-20 ng/mL; 0.1-10 ng/mL
Tiotropium
LC/MS/MS
0.5-100 pg/mL
Human EDTA Plasma
LIST OF BIOANALYTICAL METHODS
Bioanalytical
Compound
Calibration Range
Bioanalytical matrix
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Betahistine metabolite (2-pyridylacetic acid)
Bicalutamide ((R)-(-)Bicalutamide ; (S)-(+)
Bicalutamide (R-(-) Bicalutamide ; (S)-(+)
Bicalutamide (R-(-) Bicalutamide ; (S)-(+)
Budesonide
LC/MS/MS
5-1000 pg/mL
Human EDTA Plasma
Carbidopa ; Levodopa
LC/MS/MS
2-75 ng/mL ; 10-750 ng/mL
Human EDTA Plasma
Carbidopa ; Levodopa
LC/MS/MS
2-100 ng/mL ; 10-750 ng/mL
Human EDTA Plasma
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Carbidopa ; Levodopa
LC/MS/MS
5-250 ng/mL ; 10-2500 ng/mL
Human EDTA Plasma
Carbidopa ; Levodopa
LC/MS/MS
5-300 ng/mL ; 10-2500 ng/mL
Human EDTA Plasma
Chlorpheniramine (S-(+)-clorpheniramine ;
2-2000 ng/mL ; 2-600 ng/mL ; 1-400 ng/mL
Deflazacort metabolite (21-OH-Deflazacort)
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Donepezil ((+)-Donepezil ; (-)-Donepezil)
Donepezil ((+)-Donepezil ; (-)-Donepezil)
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Fluticasone
LC/MS/MS
2-250 pg/mL
Human EDTA Plasma
Fluvastatin ((+)-3R,5S-Fluvastatin ; (-) -3S, 5R-
Formoterol
LC/MS/MS
0.4-100 pg/mL
Human EDTA Plasma
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Ibuprofen (R-(-)-ibuprofen ; S-(+)-ibuprofen)
Ibuprofen (R-(-)-ibuprofen ; S-(+)-ibuprofen)
Lercanidipine ((-)-R-Lercanidipine ; (+)-S-
Linopristin ; Linopristin Metabolite (RPR
Linopristin ; Linopristin Metabolite (RPR
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Metamizol metabolite (4-methylaminoantipyrine)
Metoprolol ((+)-R-Metoprolol ; (-)-S-Metoprolol)
Morphine ; Morphine-3-beta-D-glucoronide ;
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Paliperidone ((-) Paliperidone ; (+) Paliperidone)
Pentoxyfiline ; Metabolite I ; Metabolite V
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Salmeterol
LC/MS/MS
2-250 pg/mL
Human EDTA Plasma
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Simvastatin ; b-Hydroxy Acid Simvastatin
Simvastatin ; b-Hydroxy Acid Simvastatin
∆9-Tetrahydrocannabinol; 11-Hydroxy-∆9-
0.2-20 ng/mL; 0.2-20 ng/mL; 0.1-10 ng/mL
Tiotropium
LC/MS/MS
0.5-100 pg/mL
Human EDTA Plasma
Tolterodine ; 5-hydroxymethyl Tolterodine
Tolterodine ; 5-hydroxymethyl Tolterodine
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
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Anapharm Europe S.L.U. Encuny, 22, 2nd Floor 08038 Barcelona, Spain Tel. + 34 93 223 8636 info@anapharmeurope.com www.anapharmeurope.com
Source: http://www.anapharmeurope.com/pdf/Anapharm%20Europe%20Bioanalytical%20methods.pdf
Generic name Brand names Common uses[2] Possible side effects[2] Mechanism of action Aminoglycosides Infections caused by Gram-negative bacteria, such as subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site leaving the bacterium unable to synthesize Ansamycins Carbacephem prevents bacterial c
Blood Donor Criteria 1. Donors must weigh more than 45 kilograms and be in good health. 2. Donors must be between the ages of 17-70 years. Those who are 17 years of age and wish to donate must have permission from parents. A first time donor must be less than 55 years old. 3. Donors may not have diar hea or symptoms of a fever 7 days before donating. 4. Women donors may not be pregnant, or
A |
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H |
I |
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V |
W |
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0-9 |
LIST OF BIOANALYTICAL METHODS 
Betahistine metabolite (2-pyridylacetic acid)
Bicalutamide ((R)-(-)Bicalutamide ; (S)-(+)
Bicalutamide (R-(-) Bicalutamide ; (S)-(+)
Bicalutamide (R-(-) Bicalutamide ; (S)-(+)
Budesonide 
Carbidopa ; Levodopa 
Donepezil ((+)-Donepezil ; (-)-Donepezil)
Donepezil ((+)-Donepezil ; (-)-Donepezil)
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Fluticasone 
Ibuprofen (R-(-)-ibuprofen ; S-(+)-ibuprofen)
Ibuprofen (R-(-)-ibuprofen ; S-(+)-ibuprofen)
Lercanidipine ((-)-R-Lercanidipine ; (+)-S-
Linopristin ; Linopristin Metabolite (RPR
Linopristin ; Linopristin Metabolite (RPR
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Metamizol metabolite (4-methylaminoantipyrine)
Metoprolol ((+)-R-Metoprolol ; (-)-S-Metoprolol)
Morphine ; Morphine-3-beta-D-glucoronide ;
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Paliperidone ((-) Paliperidone ; (+) Paliperidone)
Pentoxyfiline ; Metabolite I ; Metabolite V
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Salmeterol 
Simvastatin ; b-Hydroxy Acid Simvastatin
Simvastatin ; b-Hydroxy Acid Simvastatin
∆9-Tetrahydrocannabinol; 11-Hydroxy-∆9-
0.2-20 ng/mL; 0.2-20 ng/mL; 0.1-10 ng/mL
Tiotropium 
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
Warfarin (R-(+) Warfarin ; S-(-)-Warfarin)
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