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Microsoft word - 1211 jadelle nz cmi.doc
NEW ZEALAND CONSUMER MEDICINE INFORMATION
levonorgestrel-releasing implant 75 mg
What is in this leaflet
Please read this leaflet carefully before you start using Jadelle.
This leaflet answers some common questions about Jadelle. It does not contain all the
available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you using Jadelle
against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist.
Keep this leaflet.
You may need to read it again.
What Jadelle is used for
Jadelle is a contraceptive implant, used to prevent pregnancy. Contraceptive implants such as Jadelle are among the most effective reversible methods of contraception known. However, no contraceptive is 100 percent effective The implants contain a synthetic hormone, levonorgestrel, which is also one of the active ingredients used in many oral contraceptives. Immediately after the insertion of Jadelle implants, low doses of the hormone start to be released continuously into your body.Jadelle prevents pregnancy through a combination of mechanisms. The most important of these are inhibition of the egg release by stopping it maturing and changing the cervical mucus consistency, making it more difficult for sperm to reach the egg. Other mechanisms may also be involved. When Jadelle implants are removed, your fertility will resume. Jadelle is inserted just beneath the skin on the inside of your upper arm and is performed by your doctor. Although the implant may be removed at any time, it must be removed no later than five years after insertion. If you weigh over 60 kg, your doctor may recommend that you have the implant removed or have a new implant inserted after the 4th year. Your doctor may have prescribed Jadelle for another reason. Ask your doctor if you have any questions about why Jadelle has been prescribed for you.
Before you use Jadelle
When you must not use it
Do not use Jadelle if:
you have or have had a blood clot (in your legs, lungs or other parts of your body)
you have or have had a liver tumour or liver disease as long as the liver function
you have or are suspected of having cancer relating to sex hormones you have abnormal vaginal bleeding.
Do not use Jadelle if have an allergy to:
any medicine containing levonorgestrel
any of the ingredients listed at the end of this leaflet
Some of the symptoms of an allergic reaction may include:
swelling of the face, lips, tongue or other parts of the body
Do not use this medicine if you are pregnant or you think you may be pregnant.
affect your developing baby if you use Jadelle during pregnancy. Do not use this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your
pharmacist for disposal.
If you are not sure whether you should start using Jadelle, talk to your doctor. Before you start to use it
Before inserting Jadelle implants your doctor will ask about your medical history, perform a
physical examination and make sure that you are not pregnant. After some time has elapsed
from the insertion, your doctor may want to check the implant site. As with other hormonal
contraceptives, you will need regular check-ups while you are using Jadelle implants. Your
doctor will tell you how often.
Jadelle implants are different from other contraceptive methods. Some doctors have more
experience than others with inserting and removing Jadelle. Discuss with your doctor or
nurse to find out whether your doctor is familiar with the insertion and removal of Jadelle
You can decide to have your Jadelle implants removed at any time. Removal may be more
difficult than the insertion. It may take longer and involve more pain. In a small proportion of
users (approximately 1.5%) the removal of Jadelle was considered by the women concerned
to have adversely affected them. This could include being difficult to remove, requiring a long
incision or more than one visit to have the rods removed. Jadelle may also leave scars, a risk
that does not exist with some other contraceptive methods.
Once Jadelle is inserted, it may change your menstrual bleeding patterns. You may
experience irregular bleeding, bleeding between periods, longer periods, spotting or no
bleeding at all. For most women these irregularities will diminish gradually with continuing use. Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. Not all women can use Jadelle implants. Do not use Jadelle if you have any of the conditions listed below. Your doctor may advise you to use a different type of hormonal contraception or an entirely different (non-hormonal) method of birth control. Tell your doctor if:
you or someone in your family has a history of thrombosis or a blood clotting disorder,
stroke, heart attack or coronary artery disease
you have risk factors for blood clots
you have or have had migraines or frequent headaches
you have or have had lumps in your breast, mastopathy (breast disease) or an
abnormal mammogram (breast X-ray picture) or someone in your family has had breast cancer
you have liver disease you have depression
you have a condition which may worsen with fluid retention
you have not had your menstrual periods
you have or have had inflammation of your veins (superficial phlebitis)
you have the following inflammatory diseases: scleroderma (thickening and
hardening of the skin), lupus erythematosus disseminate (a disease affecting the skin all over the body) or rheumatoid arthritis (disease affecting the joints)
you have a condition that occurred with previous use of sex hormones or during
pregnancy (e.g. itching, gall stones, haemolytic uraemic syndrome – a disorder of blood clotting causing failure of the kidneys, hearing loss or a skin disease called herpes gestationis).
If you have not told your doctor about any of the above, tell them before you start using
In rare cases benign liver tumours and even more rarely, malignant liver tumours have been
reported in users of hormonal contraceptives such as Jadelle. These tumours may lead to
internal bleeding. Contact your doctor immediately if you have severe pain in your abdomen. Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines that you buy
without a prescription from your pharmacy, supermarket or health food shop. You should
also tell any health professional who is prescribing a new medication for you that you are
Some medicines may interfere with Jadelle. These include:
medicines used to treat epilepsy such as phenytoin, primidone, barbiturates (e.g.
phenobarbitone), carbamazepine, oxcarbazepine
medicines used to treat tuberculosis such as rifampicin
medicines used to treat fungal infections, such as griseofulvin
These medicines may be affected by Jadelle, or may affect how well it works. You may need to use additional non hormonal (barrier) methods of contraception (such as condoms or diaphragm) while you are taking any of these medicines and for four weeks after stopping them. Your doctor will be able to advise you about how long you will need to use additional contraceptive methods. Your doctor or pharmacist has more information on medicines to be careful with or avoid while using Jadelle.
How to use Jadelle
One Jadelle administration is effective for 5 years and can be removed at any time. When to start using Jadelle
If you have not used a hormonal contraceptive in the past month, Jadelle should be inserted
within 7 days from the onset your menstrual period. If the implants are inserted at any other
time, pregnancy must be excluded before insertion but make sure you also use additional
non hormonal (barrier) methods (e.g. condoms) at least 7 days after insertion. Your doctor will advise you when to use Jadelle:
if you have had a miscarriage or an abortion.
Changing from a combined oral contraceptive (COC)
If you are switching from a combined oral contraceptive, Jadelle should be inserted on the
day after taking the last active tablet or at the latest, on the day after the tablet free interval or
placebo tablet phase. However, in this instance you will need to make sure you also use
additional non hormonal (barrier) methods (e.g. condoms or a diaphragm) during the last
tablet free interval or placebo tablet phase before switching to Jadelle. Changing from a progestogen only method (minipill, injection, implant) or from a
progestogen-releasing intrauterine system (IUS)
Jadelle should be inserted the day when you stop taking the minipill, when your next injection
is due, or on the day that your implant or IUS is removed.
Insertion of Jadelle implants
Jadelle implants must be inserted and removed by a health professional who is familiar with
the procedure. The two thin Jadelle implants will be inserted just beneath the skin on the
inside of your upper arm with a special inserter called a trocar. This will involve a minor
surgical procedure. If you are right-handed, usually your left arm is used, and if you are left
handed, your right arm.
A local anaesthetic will be used as a small incision has to be made to insert the rods. The
two rods are placed underneath the skin, one at a time. Since a local anaesthetic is used,
you should not feel any pain. There may be some discolouration, bruising or swelling at the
implant site for a few days after the insertion but these should not interfere with your normal
Occasionally, an infection may occur or there may be transient pain or itching. The following
skin reactions have been reported in connection with the insertion of other similar
levonorgestrel implants: scarring, blistering, sloughing, ulceration, tingling and numbness.
After the procedure, the insertion site will be closed with a skin closure and bandaged. Keep
the wound dry and bandaged for three days. Do not bump the insertion site or lift anything
heavy with that arm during this time.
When and how JADELLE implants are removed
Jadelle implants must be removed at the end of five years by a trained doctor. If you want to
continue using Jadelle implants, a new set can be inserted when the rods are removed.
If you weigh over 60 kg, your doctor may recommend the removal and change of implants
after the fourth year of use. Do not put off the removal after the five years have elapsed,
since the implants will start to lose their effectiveness after that period. If you cannot see a
doctor in time to have the implants removed at the end of the fifth year, you must use
additional non hormonal (barrier) methods (e.g. condoms) and have the implants removed as
soon as possible.
If you do not want to have another set of Jadelle implants inserted and do not wish to
become pregnant, you must start using another method of contraception immediately
after the removal
. The contraceptive effect of Jadelle stops very quickly after they have
If you want to stop using Jadelle before five years, the implants can be removed at any time.
If you do not wish to become pregnant, you must start using another method of
Removal of Jadelle implants
The Jadelle implants must be removed by a trained doctor. Do not try to remove them
yourself. The implant site will be anaesthetised and a small cut will be made in the skin. After
removal, keep the wound clean, dry and bandaged for 3 to 5 days or until the skin has
healed. The removal of Jadelle implants will usually take more time than the insertion.
Bruising may occur at the site following removal. If the rods are found to be too deep, they
may be more difficult to remove. If both rods cannot be removed at the first attempt, you will
need to see the doctor again for another attempt. You should use another method of
contraception until both rods have been removed.
In cases where removal of the rods has been difficult, there have been reports of pain,
numbness, tingling and scarring in the upper arm.
While you are using Jadelle
Things you must do
If you are about to be started on any new medicine tell your doctor and pharmacist that you
are using Jadelle.
See your doctor immediately if you notice possible signs of thrombosis. These
severe pain or heaviness in the chest breathlessness
any unusual, severe, or prolonged headache or migraine attack
partial or complete loss of vision, or double vision
sudden changes to your hearing, sense of smell, or taste
weakness or numbness in any part of your body
severe pain, swelling or discolouration in either of your legs.
If you are going to have surgery, tell the surgeon or anaesthetist beforehand that you
are using this medicine.
The risk of having deep venous thrombosis is temporarily
increased as a result of an operation or immobilisation (for example, when you have your leg
or legs in plaster or splints).
If you are about to have any blood tests, tell your doctor that you are using this medicine. It
may interfere with the results of some tests. Keep all of your doctor’s appointments so that your progress can be checked.
Your doctor may do some tests (such as blood tests, monitoring your blood pressure and
checking the insertion site) from time to
time to make sure the medicine is working and to
prevent unwanted side
effects. If you become pregnant while using this medicine, tell your doctor immediately.
Jadelle will not protect you from HIV-AIDS or any other Sexually Transmitted Diseases
(STDs), such as chlamydia, genital herpes, genital warts, gonorrhoea, hepatitis B, human
papilloma virus and syphilis. To protect yourself from STDs, you will need to use
additional barrier contraceptives (e.g. condoms).
If you are about to start on any new medicine, remind your doctor and pharmacist that you
are using Jadelle.
In case of overdose
If you take too much (overdose)
There is no experience of overdose with Jadelle.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using Jadelle. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by the following lists of side effects. You may not experience any of
Ask your doctor or pharmacist to answer any questions you may have.
The following list includes the more common side effects of your medicine. These are usually
mild and lessen with time. If you notice any of the following side effects and they worry you, tell your doctor or
mood changes, depression, nervousness changes in libido
loss of hair from the head or body, excessive hair growth
urinary tract symptoms such as a burning or frequent need to urinate
changes in menstrual bleeding including irregular, prolonged, spotting, heavy,
bleeding or spotting between periods or absence of bleeding
itching, burning or abnormal vaginal discharge
lumps in the breast, breast discharge, breast pain
pelvic pain, back pain or pain in general
If you experience any of the following, tell your doctor immediately, or go to the
Emergency Department at your nearest hospital:
breathlessness and/or difficulty breathing
weakness, numbness or bad ‘pins and needles’ of an arm or leg
a bad fainting attack, or you collapse
unusual headaches or migraines that are worse than usual and/or visual disturbances sudden problems with your speech or eyesightyellowing of the skin and/or eyes
lower abdominal pain nerve damage associated with removal of the implant dark patches on the skin over the implant site
You may need urgent medical attention or hospitalisation. Jadelle implants may be expelled before the insertion area has healed, if this occurs please see your doctor immediately.
Other side effects not listed above may also occur in some patients. Tell your doctor if you notice any other unusual symptoms.
After using Jadelle
Store below 30oC.
Store all medicines properly and keep them out of reach of children.
What it looks like
The implants consists of two flexible, white to off-white rods 43 mm in length and 2.5 mm in
diameter each containing 75 mg levonorgestrel. The sterile implants are packed in blisters. Ingredients
silicone elastomers, colloidal anhydrous silica
Made in Finland for: Bayer New Zealand Limited 3 Argus Place, Hillcrest North Shore AUCKLAND 0627 Free phone 0800 233 988
Date of Preparation
This leaflet was prepared on 5 November 2012. See MEDSAFE website (www.medsafe.govt.nz) for latest New Zealand Consumer Medicine Information. ® Registered Trademark of the Bayer Group, Germany
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