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Thyroid Disorders: The Hidden Health Threat
When my daughter, Samantha, was 4 months old, I started to experience overwhelming fatigue. I'dwake up from a full night's sleep (Samantha blessed us with a whopping eight hours) and still feelwiped out. I'd tell myself that this was normal. I was a new mother -- I was supposed to be tired allthe time. But exhaustion wasn't my only symptom. I had also hit a major weight-loss plateau andstarted feeling blue -- with the new precious addition to my family, my life was better than ever, yetsomething just didn't seem right. Again, I chalked it up to the demands of motherhood. "It's thetoughest job in the world," friends told me. "It's supposed to be difficult." The turning point was thenext month on Christmas morning. While the rest of my family was opening presents, I was lying underthe tree, barely able to keep my eyes open. My husband suggested that I see a doctor, so right afterthe holidays I went through a series of blood tests, including ones to determine whether I had anormal thyroid.
The thyroid is a butterfly-shaped gland located in the middle of the lower neck. It secretes hormonesthat control body metabolism and, in turn, one's mood, weight, and energy levels. Levels of thesehormones -- namely thyroxine (T4) and triiodothyronine (T3) -- are controlled by thyroid-stimulatinghormone (TSH). When levels of T3 and T4 are low, the pituitary gland secretes extra TSH to signal thethyroid to increase its production of them. If the production doesn't increase, the body secretes evenmore TSH in an attempt to kick the thyroid into gear.
The doctor suspected that was the culprit, and he was right -- my TSH level was more than 20 timeswhat it should have been. I was shocked by the news but equally thrilled to have an answer. I didn'thave to live like this! Simply taking a synthetic thyroid replacement drug would, and within weeks did,reverse my symptoms. But I was lucky -- many women live with my same or worse symptoms, thinkingthere's nothing they can do.
According to the American Thyroid Association, as many as one in ten women experience postpartumthyroid disorders. And for women with a family history of thyroid dysfunctions or previous autoimmuneproblems, the rate can be as high as 25 percent.
I was diagnosed with postpartum thyroiditis, the most common postpartum thyroid condition. Otherthyroid disorders, however, such as Graves' disease and Hashimoto's thyroiditis can also be triggeredby hormonal changes during and after pregnancy. Here's a breakdown of each:
Under normal circumstances, the immune system fights foreign matter in the body.
During pregnancy, however, genetic material from the father is foreign, so the immune system is
suppressed to protect the fetus, explains Alex Stagnaro-Green, M.D., professor of internal medicine
and obstetrics and gynecology at the New Jersey Medical School in Newark. Postpartum, the immune
system rebounds, becoming stronger than usual. In certain predisposed women, this change can causethe body to attack and inflame the thyroid.
Classic postpartum thyroiditis, which can happen after any pregnancy, even one that ends inmiscarriage, typically manifests in two phases: The initial hyperthyroid phase (when the thyroid isoveractive) first occurs within four months after delivery and usually lasts one to three months.
Symptoms during this period-which are often so mild they go undetected-include anxiety, heartpalpitations, weight loss, insomnia, and fatigue. Usually, the inflammation resolves itself. Sometimes,however, this overactivity can cause the thyroid to release all of its stored hormone. The result is aperiod of hypothyroidism (an underactive thyroid), symptoms of which usually last 3 to 12 months andinclude fatigue, depression, sensitivity to cold, hair loss, decreased libido, poor exercise tolerance,and inability to lose weight.
The hyperthyroid phase is typically not treated, as symptoms tend to be short-
lived. If necessary, medication can be prescribed to slow down heart palpitations and reduce tremors.
The hypothyroid phase is often treated with a synthetic thyroid replacement drug called levothyroxine
(commonly known as Levothyroid or Synthroid), which restores thyroid hormones to normal levels.
Though thyroid function in 80 percent of women with this condition will self-regulate in 6 to 12months, some women (such as myself) need medication indefinitely. Also, women who haveexperienced postpartum thyroiditis are more than ten times as likely than other new moms to develophypothyroidism later, so be sure to get your thyroid checked at least once a year. And if you'replanning another pregnancy, note that there's about a 70 percent chance you'll develop postpartumthyroiditis again.
What new moms should consider:
The symptoms of postpartum thyroiditis are coincidentally the same
ones that many new moms face. That could be why most cases go undiagnosed, says Dr. Stagnaro-
Green. "Women and their doctors possibly too often attribute such changes to being a new mother and
don't think of thyroid dysfunction as a probable cause," he explains. The key, experts say, is not to
ignore your health -- a simple blood test can make all the difference.
Dina Roth Port is a freelance writer and mother of two.
Graves' disease is one of the most common causes of an overactive thyroid. It occurs
when the immune system produces antibodies that stimulate the thyroid to produce too much thyroid
hormone. This can accelerate your body's metabolism -- sometimes by as much as 60 to 100 percent-
leading to symptoms such as sudden weight loss, fatigue, a rapid heartbeat, sweating, nervousness,
increased sensitivity to heat, more frequent bowel movements, and an enlarged thyroid gland, which
may appear as a swelling at the base of your neck. Graves' disease can also cause ophthalmology
problems, including swollen or bulging eyes. Without enough protection from the eyelid, excessive
tearing, light sensitivity, blurry vision, and even damage to the optic nerve (in serious cases) can
In some cases, anti-thyroid medication called propylthiouracil can regulate
thyroid levels. It's generally considered safe to take while breastfeeding. Radioactive iodine, which
causes the thyroid to become inactive, is another common treatment, though it can't be used if you're
nursing or pregnant. Surgical removal of the thyroid is another option. In the latter two cases, you'll
likely need thyroid replacement medication for the rest of your life. As with postpartum thyroiditis,
regular monitoring is essential.
What new moms should consider:
If you're diagnosed before or during a pregnancy, you may find that
your symptoms flare after delivery as your immune system rebounds and you'll need to have your
medication readjusted. Moms who develop hyperthyroidism postpartum should be certain that their
doctor does the right tests to differentiate between postpartum thyroiditis and Graves' since the
treatments are different.
If you've been treated for Graves' disease (with radioactive iodine or surgery) and are no longerhyperthyroid, it's still crucial to notify your doctor that you were in the past if you become pregnant.
She'll probably want to check your thyroid-stimulating immunoglobulin levels (TSIG) and your baby'sdevelopment, since you might still have antibodies in your blood that can cross the placenta andaffect your baby's thyroid. After birth, be sure that your pediatrician is aware of the situation so shecan continue to monitor it. Keep in mind that if severe hyperthyroidism is left unchecked, you have ahigher risk for heart and bone problems, in addition to pregnancy problems, such as infertility,preeclampsia, miscarriage, and preterm labor.
The most common cause of an underactive thyroid is Hashimoto's, an autoimmune
disorder that causes your immune system to attack the thyroid and slowly destroy it. The result is that
the gland produces too little thyroid hormone, causing symptoms that can include weight gain,
sensitivity to cold, depression, fatigue, constipation, dry skin, and hair loss.
When you're diagnosed with a hypothyroid disorder, your doctor will likely
prescribe a synthetic thyroid replacement drug and, after your thyroid levels have stabilized, will
monitor you annually -- or more often if you become pregnant (see below).
What new moms should consider:
If you plan on having more children, know that your body has an
increased need for levothyroxine during pregnancy. "If you have a thyroid disorder when you're
pregnant, it's crucial to notify your doctor so he can adjust your medication dosage," says Erik
Alexander, M.D., assistant professor of medicine at Harvard Medical School and a thyroid expert at
Brigham and Women's Hospital's division of endocrinology in Boston. Thyroid levels should also be
checked often in the first half of pregnancy to maintain thyroid function -- since untreated maternal
hypothyroidism appears to be related to poor motor and verbal performance and a decreased IQ in
the child, says Dr. Alexander. There's also an increased risk of maternal respiratory problems,
preeclampsia, miscarriage, and stillbirth.
Postpartum, you'll probably return to your prepregnancy dose of levothyroxine and should have yourTSH level checked six weeks later to determine that your thyroid is functioning normally. If you planto breastfeed, rest assured that thyroid replacement medication poses no risks to your baby. "Thebeauty of thyroid disorders is that they're treatable," says Sethu Reddy, M.D., former chairman ofendocrinology at the Cleveland Clinic. "If monitored carefully by your regular doctor and anendocrinologist, the chances of having a healthy pregnancy and a healthy baby are very high."
Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory Abstract: Respiratory tract infections (RTIs) represent a serious problem because they are one of the most common cause of human death by infection. The search for the treatment of those diseases has therefore a great importance. In this study we provide an overview of the currently available treatments for
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