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Proper usage of drugs, chemicals and feed additives in food animals
PROPER USAGE OF DRUGS,
CHEMICALS AND FEED
ADDITIVES IN FOOD ANIMALS
Drug Definition: Usage of a
Compound with Intent
To prevent To treat To make a change in body function
Approved Drug Types
Vaccines Antibiotics/Antibacterials Chemicals Hormones/Steroids
Food Animal Residue Avoidance Databank
Within-Label Drug Usage
Approved drug for animal species on label Correct route on label Correct dosage on label Usage on label Withdrawal time on label
Drug Withdrawal Time
Time to be eliminated from body Time to be reduced to safe level in body Published on label
Drug Elimination Time
Time to be eliminated from body Not published on label
Time more than 24 hrs – considered safe
Federal law restricts this drug to
use by or on the order of a licensed veterinarian
Unapproved Drug Types
Tranquilizers (ace, thorazine) Natural tranquilizers (vitamin B6, tryptophan, herbs) Local anesthetics (procaine, lidocaine) Diuretics (except Lasix®, Diuril® for udder edema) Natural dewormers (tobacco, garlic, DE) Caffeine diuretics (coffee, tea, chocolate, soda) Alcohol tranquilizers (beer, whiskey) Human drugs (topical, oral, parenteral)
Prohibited Drug Types
Diethylsilbestrol Chloramphenicol Nitroimidazoles Clenbuterol Dipyrone Fluoroquinolines Glycopeptides Nitrofurans (oral, topical, parenteral) Gentian Violet Sulfonamide (adult dairy cattle) Phenylbutazone (adult dairy cattle)
Extra-Label Drug Usage
Federal law restricts extra-label drug use by or on the order
Dispensed: Veterinarian Label Prescribed: Veterinarian Prescription Not permitted in feed and water
Approved Drugs for Rabbits
No medicated feed antibacterials No antibiotics No dewormers
Each ml contains 200mg of oxytetracycline base as oxytetracycline amphoteric
For Use in Beef Cattle,
Nonlactating Dairy Cattle and Swine
injection) is a sterile, ready-to-use solution
refrigeration; however, it is recommended
for the administration of the broad-spectrum
that it be stored at room temperature, 15°-
antibiotic oxytetracycline (Terramycin) by
30°C (59°-86°F). The antibiotic activity of
injection. Terramycin, discovered by Pfizer
scientists, is an antimicrobial agent that is
diminished in the presence of body fluids,
effective in the treatment of a wide range of
disease caused by susceptible gram-positive and gram-negative bacteria.
Discontinue treatment at least 28 days prior
LIQUAMYCIN® LA-200 ® administered to
to slaughter of cattle and swine.
cattle or swine for the treatment of
bacterial pneumonia at an intramuscular
dosage of 9 milligrams of oxytetracycline
Not for use in lactating dairy animals.
per pound of body weight, has been
demonstrated in clinical trials to be as
effective as two or three repeated, daily
treatments of Terramycin ® Injectable at
3 to 5 milligrams per pound of body
Exceeding the highest recommended dosage level of drug per pound of body weight per day,
administering more than the recommended number of treatments, and/or exceeding 10 ml
intramuscularly per injection site in adult beef cattle and nonlactating dairy cattle, and 5 ml
intramuscularly per injection site in adult swine, may result in antibiotic residues beyond the
Reactions of an allergic or anaphylactic nature, sometimes fatal, have been known to occur in hypersensitive
animals following the injection of oxytetracycline. Such adverse reactions can be characterized by signs such as restlessness, erection of hair, muscle trembling; swelling of eyelids, ears, muzzle, anus and vulva ( or scrotum and sheath in males); labored breathing, defecation and urination, glassy-eyed appearance, eruption of skin plaques, frothing from the mouth, and prostration. Pregnant animals that recover may subsequently abort. At the first sign of any adverse reaction, discontinue use of this product and administer epinephrine at the recommended dosage levels. Call a veterinarian immediately.
Shock may be observed following intravenous administration, especially where highly concentrated materials
are involved. To minimize this occurrence, it is recommended that LIQUAMYCIN® LA-200 ® be administered slowly by this route.
Shortly after injection, treated animals may have transient hemoglobinuria resulting in darkened urine.
As with all antibiotic preparations, use of this drug may result in overgrowth of non-susceptible organisms,
including fungi. A lack or response by the treated animal, or the development of new signs, may suggest that an overgrowth of non-susceptible organisms has occurred. If any of these conditions occur, consult your veterinarian.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving
LIQUAMYCIN® LA-200 ® in conjunction with penicillin.
: Store at room temperature,
15°-30°C (59°-86°F). Keep
A diuretic-saluretic for prompt relief of
Lasix ® (furosemide), a diuretic, is an anthranilic
acid derivative with the following structural
Caution: Federal law restricts this drug to
use by or on the order of a licensed
Lasix ® (furosemide) is a chemically distinct
diuretic and saluretic pharmacodynamicallycharacterized by the following:
1) A high degree of efficacy, low-inherent toxicity and a high therapeutic index.
2) A rapid onset of action and of comparatively short duration. 1,2
3) A pharmacological action in the functional area of the nephron, i.e., proximal and distal tubules and the ascending limb of the loop of Henele, 2, 3, 4
4) A dose-response relationship and a ratio of minimum to maximum effective dose
Generic name: Furosemide (except in United
Kingdom-frusemide). Chemical name: 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.
5) If may be administered orally or parenterally. It is readily absorbed from the intestinal tract and well tolerated. The intravenous route produces the most rapid diuretic response.
Dogs Cats & Horses
(furosemide) is from the activity of the
extracellular fluids. The rationale for the
excretion minimize the possibility of its
associated with cardiac insufficiency and
crystalluria. Lasix® (furosemide) has no
inhibitory effect on carbonic anhydrase or
aldosterone activity in the distal tubule.
The drug possesses diuretic activity either
in presence of acidosis or alkalosis 1,2,3,4,5,6,7
Lasix ® (furosemlde) is indicated for the
DOG AND CAT
One-half to one 5O mg scored tablet per 25
edema of the mammary gland and associated
pounds body weight. One 12.5 mg tablet per 5
to 10 pounds body weight. Administer once or
twice daily permitting a 6- to 8-hour interval
CONTRAINDICATIONS - PRECAUTIONS
between treatments. In refractory or severe
Lasix ® (furosemide) is a highly effective
edematous cases the dosage may be doubled or
diuretic-saluretic which it given in excessive
increased by increments of 1 mg per pound body
electrolyte imbalance Therefore, the dosage and
paragraphs “Dosage and Administration“
schedule may have to be adjusted to the patient's needs. The animal should be observed
for early signs of electrolyte imbalance and
DOG AND CAT
corrective measures administered. Early signs
Administer intramuscularly or Intravenously 1/4
of eleclrolyte imbalance are increased thirst,
lethargy, drowsiness or restlessness fatigue,
Administer once or twice daily, permitting a 6- to
oliguria, gastro-intestinal disturbances and
8-hour interval between treatments. In refractory
tachycardia. Special attention should be given to
or severe edematous cases the dosage may be
potassium levels. Lasix ® (furosemide) may
doubled or increased by increments of 1 mg per
lower serum calcium levels and cause tetany in
rare cases of animals having an existing
The individual dose is 250 to 500 mg (5 to
Parental: Lasix ® (furosemide) injection
intravenously once or twice daily at 6- to 8-
hour intervals until desired results are
stabilized with myristyl-gamma-picolinium
adjust dosage schedule accordingly. Do
sodium sulfite 0.1% with sodium chloride
not use in horses intended for food.
intramuscularly or intravenously is 500 mg
twice daily at 12-hour intervals. Treatment
not to exceed 48 hours postparturition.
not be used for food. Cattle must not be
CAUTION. Federal law restricts this drug to use by or on
the order of a licensed veterinarian
Acepromazine Maleate, a potent neuroleptic agent with a
low order of toxicity, is of particular value In the
tranquilization of dogs, cats, and horses. Its rapid action
and lack of hypnotic effect are added advantages.
According to Baker,' the scope of possible applications
for this compound in veterinary practice is only limited by
the imagination of the practitioner.
Acepromazine (10.(3.(dimethylamino) propyl)
phenothiazin-2-yl-methyl ketonel Maleate has the
PromAce (Acepromazine Maleate) has a
depressant effect on the central nervoussystem and therefore causes sedation, muscular
PromAce Injectable can be used as an aid in
relaxation and a reduction in spontaneous
activity It acts rapidly, exerting a prompt and
transportation. Particularly useful whenused in conjunction with local anesthesia for
firing, castration, neurectomy, removal of
DOGS AND CATS
skin tumors, ocular surgery and applying casts.
PromAce Injectable and Tablets can be used as an aid in controlling intractable animals during examination, treatment. grooming, x.ray, and minor surgical procedures; to alleviate itching as a result of skin irritation; as an antie-metic to control vomiting associated with motion sickness. PromAce Injectable is particularly useful as a preanesthetic agent (1) to enhance and prolong the effects of barbiturates, thus reducing the requirements for general anesthesia; (2) as an adjunct to surgery under Local anesthesia.
Electromedicine CES For Mild Traumatic Brain Injury Based on the consistently robust results of cranial electrotherapystimulation (CES) seen throughout this preliminary data, the useof this safe and effective electromedical modality as an adjunct tomedical and psychological interventions for mild traumatic brainCranial electrotherapy stimulation Electroconvulsive Therapy,Electroanes-
History of NLEP Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It usually affects the skin and peripheral nerves, but has a wide range of clinical manifestations. The disease is characterized by long incubation period generally 5-7 years and is classified as paucibacillary or mulitbacillary, depending on the bacillary load. Leprosy is a leading cause of permanent p