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Microsoft word - 7 pro目次-0617.doc

June 21 (Sunday) 14:00~ Registration 15:30~15:50 <Ocean Hall> Opening Opening Remarks: F. Peter Guengerich (Vanderbilt University School of Medicine) 15:50-16:45 Plenary Lecture <Ocean Hall> Shigeaki Kato (University of Tokyo): Nuclear vitamin D receptor-regulated expression of the human CYP27B1 gene mediates the DNA methylation/demetylation Session 1 Bioinformatics Chairs: Osamu Gotoh, Daniele Werck-Reichhart S1-L1: 17:00-17:30 Osamu Gotoh (Kyoto University): Birth and death of P450 genes in metazoan S1-L2: 17:30-18:00 Daniele Werck-Reichhart (CNRS-University, de Strasbourg): P450 evolution and neofunctionalization in plants: emergence of a novel phenolic pathway in Brassicaceae S1-L3: 18:00-18:30 Jongsun Park (Seoul National University): Integrated bioinformatics platforms for identifying and analyzing cytochrome P450s from diverse genomic resources S1-L4: 18:30-19:00 Masanori Arita (University of Tokyo): Data management of cross-disciplinary June 22 (Monday) 9:00~13:00 < Summit Hall > Session 2 P450s in metabolism and drug discovery Chairs: Hiroshi Yamazaki, Steven J. Leeder S2-L1: 9:00-9:30 Steven J. Leeder (Children's Mercy Hospital and Clinics): Ontogeny and pediatric pharmacogenetics in drug development S2-L2: 9:30-10:00 Caroline Lee (Pfizer Global Research & Development): Novel application of cytochrome P450 tools to potentially impact drug design and evaluate drug interactions S2-L3: 10:00-10:30 Yasuhiro Yamada (Mitsubishi Tanabe Pharma Corp.): A strategic approach to positioning of cytochrome P450 studies and risk assessment for drug-drug interaction 10:30-11:00 (Coffee Break) S2-L4: 11:00-11:30 Hiroshi Yamazaki (Showa Pharmaceutical University): Remarked properties of human cytochrome P450 1A2 and 3A5 in function and cooperativity for drug development P-2 (S2-S1): 11:30-11:45 Mariko Nakano (University of Washington): Tissue distribution and metabolism of arachidonic acid by the orphan P450, CYP4V2 P-3 (S2-S2): 11:45-12:00 Shinichi Ikushiro (Toyama Prefectural University): Functional co-expression of UDP-glucuronosyltransferases, in yeast microsomes P-4 (S2-S3): 12:00-12:15 Takahiro Murai (University of Utah): CYP3A5-specific mechanism-based inactivation by fluticasone propionate, an inhaled glucocorticoid P-5 (S2-S4): 12:15-12:30 Sasitorn Aueviriyavit (Chiba University): Humanized P450 mouse: (2) Functional expression of human CYP3a isoforms in Cyp3a-Hac mice and their application in drug-drug interaction study via mechanism-based inactivation P-6 (S2-S5): 12:30-12:45 Xinxin Ding (Wadsworth Center, New York State Department of Health): Role of mouse CYP2A5 in nicotine clearance and testosterone homeostasis P-7 (S2-S6): 12:45-13:00 Danielle Sevior (RMIT University): Using the rapid N-in-one cocktail to screen commercially available herbal products for CYP inhibition Session 3 Structure and function of P450s Chairs: Andrew Munro, Eric F. Johnson S3-L1: 9:00-9:30 Eric F. Johnson (The Scripps Research Institute): Structural flexibility underlying the broad substrate specificity of human P450 2C9: Conformational changes upon substrate binding as determined by X-ray crystallography S3-L2: 9:30-10:00 David Leys (The University of Manchester): Crystal structures of S3-L3: 10:00-10:30 Emily E. Scott (The University of Kansas): Structures of human cytochrome 10:30-11:00 (Coffee Break) S3-L4: 11:00-11:30 Shingo Nagano (RIKEN SPring-8 Center): Cytochrome P450 in biosynthesis P-32 (S3-S1): 11:30-11:45 Stephen G. Bell (University of Oxford): The CYP199A2 Class I P450 system from the metabolically diverse bacterium Rhodopseudomonas palustris P-33 (S3-S2): 11:45-12:00 Natallia Strushkevich (SGC, University of Toronto): Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole P-34 (S3-S3): 12:00- 12:15 Michael R. Wester (Pfizer Global Research & Development): Crystal structures of CYP3A4 in complex with bromocriptine and clotrimazole: Evidence of structural plasticity in the active site P-35 (S3-S4): 12:15-12:30 Dmitri R. Davydov (University of California, San Diego): Allosteric transitions in cytochrome P450 3A4: A multi-step substrate binding mechanism revealed with novel fluorescent ligands P-36 (S3-S5): 12:30-12:45 Lianhua Xu (University of Tokyo): Crystal structures of filipin hydroxylases (CYP105P1 and CYP105D6) from Streptomyces avermitilis 13:00~14:30 ~Lunch~ 14:30~18:30 < Summit Hall > Session 4 Post-transcriptional, post-translational, and epigenetic events Chairs: Tsuyoshi Yokoi, Daniel W. Nebert S4-L1: 14:30-15:00 Maria Almira Correia (University of California, San Francisco): Post-translational CYP3A phosphorylation/ubiquitination: Means to a degradative end S4-L2: 15:00-15:30 Daniel W. Nebert (University Cincinnati Medical Center): Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1 S4-L3: 15:30-16:00 Alvaro Puga (University of Cincinnati College of Medicine): Epigenetic S4-L4: 16:00-16:30 Miki Nakajima (Kanazawa University): MicroRNA as a regulator of human 16:30-17:00 (Coffee Break) P-50 (S4-S1): 17:00-17:15 Takuya Mohri (Kanazawa University): MicroRNA regulates the expression of P-51 (S4-S2): 17:15-17:30 Tsuyoshi Yokoi (Kanazawa University): miR-24 represses human HNF4α P-52 (S4-S3): 17:30-17:45 Johan Lundqvist (Uppsala University): Regulation of key steroidogenic CYP enzymes – a potential novel role for 1α,25-dihydroxyvitamin D3 17:45-18:00 Markus Storvik (University of Kuopio): The effects of tobacco-smoke and dietary compounds on Phase I and Phase II xenobiotic metabolism enzyme genes through AH-receptor and tissue-specific transcription factors S4-L5: 18:00-18:30 Negishi Masahiko (NIEHS, NIH): Signal-mediated mechanism of CAR Session 5 New mechanisms of P450 reactions Chair: F. Peter Guengerich S5-L1: 14:30-15:00 F. Peter Guengerich (Vanderbilt University School of Medicine): Kinetics of sequential reactions catalyzed by P450 enzymes S5-L2: 15:00-15:30 Fumihiko Sato (Kyoto University): Novel P450s in isoquinoline alkaloid S5-L3: 15:30-16:00 Andrew Munro (University of Manchester): Characterization of P450 redox systems in the human pathogen Mycobacterium tuberculosis S5-L4: 16:00-16:30 Paul Ortiz de Montellano (University of California, San Francisco): Cytochrome P450 conformation and catalysis probed by unnatural amino acid substitutions 16:30-17:00 (Coffee Break) P-54 (S5-S1): 17:00-17:15 Arti Singh (The University of Queensland): Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations P-55 (S5-S2): 17:15-17:30 Tatyana Spolitak (University of Michigan): Evidence for catalytic intermediates involved in generation of the chromopyrrolic acid scaffold of rebeccamycin by joint RebO and RebD action. The views on the role of P450s in oxidative coupling reactions 18:30~21:00 Poster Session I (Posters of Sessions 1 - 5) June 23 (Tuesday) 9:00~13:00 < Summit Hall > Session 6 Transcriptional regulation Chairs: Masahiko Negishi, Frank J. Gonzalez S6-L1: 9:00-9:30 Frank J. Gonzalez (National Cancer Institute): Regulation of human P450s: P-60 (S6-S1): 9:30-9:45 Nico Scheer (TaconicArtemis): Use of humanized mouse models to study the transcriptional regulation of Cytochrome P450 genes 9:45-10:00 Yoshihiro Konno (NIEHS, NIH): Nuclear xenobiotic receptor PXR locks co-repressor SMRT onto the CYP24A1 promoter to attenuate vitamin D3 activation P-62 (S6-S3): 10:00-10:15 Jin-ding Huang (National Cheng Kung University): Transcriptional inhibition of CYP3A4 as novel mechanism of drug-drug interaction P-63 (S6-S4): 10:15-10:30 Kaoru Kobayashi (Chiba University): A compound in fetal bovine serum modulates the activation of pregnane X receptor 10:30-11:00 (Coffee Break) S6-L2: 11:00-11:30 Oliver Hankinson (University of California, Los Angeles): Transcriptional regulation of CYP1A1, CYP1B1, and CYP2S1 S6-L3: 11:30-12:00 Akinori Ohta (University of Tokyo): Control of cytochromes P450 production by an Opi1-family transcription factor in yeast Yarrowia lipolytica S6-L4: 12:00-12:30 Graham Robertson (The University of Sydney): Transcriptional repression of hepatic drug clearance pathways by tumour-derived cytokines P-64 (S6-S5): 12:30-12:45 Jae-Gook Shin (Inje University College of Medicine): Pharmacogenomics of transcription regulation in drug metabolism and pharmacokinetics P-65 (S6-S6): 12:45-13:00 Uli Zanger (Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology): Pathway-oriented pharmacogenomics approach to probe transcriptional regulation of CYP3A4 Session 7: Heme-thiolate proteins Chair: Toru Shimizu, Huiying Li S7-L1: 9:00-9:30 Hofrichter Martin (International Graduate School of Zittau): Aromatic peroxygenases from mushrooms: extracellular heme-thiolate proteins of a new enzyme sub-subclass? S7-L2: 9:30-10:00 Toru Shimizu (Tohoku University): The critical role of the thiolate-heme complex in the functioning of heme-sensor proteins S7-L3: 10:00-10:30 Huiying Li (University of California Irvine): Engineering a P450BM3-like red FMN semiquinone into neuronal nitric oxide synthase 10:30-11:00 (Coffee Break) S7-L4: 11:00-11:30 Shigetoshi Aono (National Institutes of Natural Sciences): Physiological role of thiolate coordination to the heme in CooA from R. rubrum P-72 (S7-S1): 11:30-11:45 Hirofumi Shoun (University of Tokyo): NADH-peroxidase activity of multi-functional detoxifying enzyme, P450nor P-73 (S7-S2): 11:45-12:00 Yasuhiro Mie (AIST): Electrochemically-driven drug metabolism by human cytochrome P450 immobilized on hydrophobic electrode surface P-74 (S7-S3): 12:00-12:15 Kelath M. Manoj (Vellore Institute of Technology): Kinetics of one-electron oxidations by chloroperoxidase: What is the analogous take-home lesson for CYPs? P-75 (S7-S4): 12:15-12:30 Jotaro Igarashi (Tohoku University): The heme-binding site of the Heme-regulated Inhibitor (HRI), and the role of the heme regulatory motif in heme sensing 13:00~ Excursion 19:00~ Banquet ( at KARIYUSHI BEACH HOTEL) June 24 (Wednesday) 9:00~13:00 < Summit Hall > Session 8 Biotechnology I Chairs: Rita Bernhardt, Toshiyuki Sakaki S8-L1: 9:00-9:30 Rita Bernhardt (Saarland University): Engineering CYP106A2 for changed substrate specificity and characterization of new substrates S8-L2: 9:30-10:00 James R. Halpert (University of California, San Diego): Engineering of mammalian cytochromes P450 2B and 3A by site-directed mutagenesis and directed evolution S8-L3: 10:00-10:30 Toshiyuki Sakaki (Toyama Prefectural University): Construction of a highly active vitamin D hydroxylase based on crystal structure of CYP105A1 and its application to production of 1α,25-dihydroxyvitamin D<sub>3</sub> 10:30-11:00 (Coffee Break) S8-L4: 11:00-11:30 Akira Arisawa (Mercian Corporation): Actinomycete cytochrome P450 from Pseudonocardia autotrophica that catalyzes vitamin D<sub>3</sub> hydroxylation P-80 (S8-S1): 11:30-11:45 Hirofumi Ichinose (Kyushu University): Functional characterization of cytochrome P450 from the white-rot fungus Phanerochaete chrysosporium P-81 (S8-S2): 11:45-12:00 Sun-Ha Park (Chonnam National University): Engineering of bacterial P450 BM3 for human P450 2A6 activity with indigo formation P-82 (S8-S3): 12:00-12:15 Shinya Fushinobu (University of Tokyo): Altering the substrate specificity of 12:15-12:30 Hidehiko Hirakawa (University of Tokyo): Chimeric self-sufficient P450 system P-84 (S8-S5): 12:30-12:45 Sjef Cornelissen (TU Dortmund): A cytochrome P450 based bioprocess for limonene hydroxylation to perillyl alcohol Session 9 New aspects of P450 functions Chairs: Hirofumi Shoun, John H. Dawson S9-L1: 9:00-9:30 John H. Dawson (University of South Carolina): Generation and reactivity of transient cytochrome P450 oxygen-containing intermediates S9-L2: 9:30-10:00 Andreas Daiber (Johannes Gutenberg University Mainz, School of Medicine): S9-L3: 10:00-10:30 Neil C. Bruce (University of York): Insight into the structure and function of XplA: a unique explosives degrading cytochrome P450 10:30-11:00 (Coffee Break) S9-L4: 11:00-11:30 Debashis Ghosh (Hauptman-Woodward Medical Research Institute): Structure and function of aromatase, the estrogen factory P-94 (S9-S1): 11:30-11:45 Kenneth Jensen (University of Copenhagen): Utilizing the power of light P-95 (S9-S2): 11:45-12:00 Hisakazu Yamane (University of Tokyo): The presence of diterpenoid phytoalexin biosynthetic gene clusters containing cytochrome P450 monooxygenase genes in rice P-96 (S9-S3): 12:00-12:15 Naoki Takaya (University of Tsukuba): Production of hydroxy-fatty acids and alkanediols by Escherichia coli cells producing fungal cytochrome P450foxy 13:00~14:30 ~Lunch~ 14:30~18:30 < Summit Hall > Session 10: Biotechnology II Chairs: Hideo Ohkawa, Frances H. Arnold S10-L1: 14:30-15:15 Frances H. Arnold (California Institute of Technology): In Darwin’s honor: artificial selection of cytochrome P450s S10-L2: 15:15-15:45 Birger Lindberg Meller (University of Copenhagen): The cytochrome P450s S10-L3: 15:45-16:15 Hideo Ohkawa (Fukuyama University): How are recombinant P450s and AhRs useful for phytomonitoring and phytoremediation of persistent organic pollutants of environmental chemicals? P-100 (S10-S1): 16:15-16:30 Dong-Hyun Kim (Chonnam National University): Generation of the human metabolite piceatannol from the anti-cancer preventive agent resveratrol by bacterial cytochrome P450 BM3 16:30-17:00 (Coffee Break) S10-L4: 17:00-17:30 Yoshikazu Tanaka (Suntory Holdings Ltd): Flower colour modification by modulating expression of cytochrome P450 genes P-101 (S10-S2): 17:30-17:45 Kwon-Young Choi (Seoul National University): Functional expression of Nocardia farcinica IFM10152 P450s in E. coli for A-ring specific monohydroxylation of daidzein P-102 (S10-S3): 17:45-18:00 Hyun-Jun Kim (Suntory Institute For Bioorganic Research): Metabolic engineering of lignan biosynthesis in Forsythia cell suspension cultures by expression of a Sesamum CYP81Q1 P-103 (S10-S4): 18:00-18:15 Satoshi Iwakami (Kyoto University): Isolation of cytochrome P450 genes and their expression in the multiple-herbicide resistant biotype of late watergrass (Echinochloa phyllopogon) Session 11 Biophysical methods & nanotechnology Chairs: Alexander Archakov, William M. Atkins S11-L1: 14:30-15:00 Ilia G Denisov (University of Illinois at Urbana-Champaign): Common properties and specific features of cytochromes P450 S11-L2: 15:00-15:30 Paul M. Champion (Northeastern University): Vibrational coherence spectroscopy investigations of heme proteins with sulphur ligation S11-L3: 15:30-16:00 Alexander Archakov (Russian Academy of Medical Sciences): Nanotechnology for visualization, counting and kinetic studies of cytochrome P450 complexes S11-L4: 16:00-16:30 William M. Atkins (University of Washington): Ligand-based NMR and single molecule spectroscopy as probes of heterotropic effects in cytochrome P450s 16:30-17:00 (Coffee Break) P-105 (S11-S1): 17:00-17:15 Wang Yuqin (Swansea University): Quantitative screening of cytochrome P450s by mass spectrometry: Specificity and sensitivity 18:30~21:00 Poster Session II (Posters of Sessions 6 - 13) June 25 (Thursday) 9:00~13:00 < Summit Hall > Session 12 Functional genomics Chairs: Damjana Rozman, Shigehiro Ohdo NOTE: The order of lectures changed! S12-L4: 9:00-9:30 Katrin Marcus (Ruhr-University Bochum): Mass spectrometry- based assay for absolute quantification of cytochrome P450s in human liver S12-L2: 9:30-10:00 Shigehiro Ohdo (Kyushu University): Molecular clock mechanisms of drug S12-L3: 10:00-10:30 William Griffiths (Swansea University): Discovering new products of CYP catalysed reactions in brain, CSF and plasma 10:30-11:00 (Coffee Break) S12-L1: 11:00-11:30 Damjana Rozman (University of Ljubljana, Faculty of Medicine): The cross-talk of CYPs in cholesterol homeostasis and drug metabolism P-107 (S12-S1): 11:30-11:45 Simon Horvat (University of Ljubljana): Generation of Cyp51 conditional knockout mice to study its function during embryo and male germ cell development P-108 (S12-S2): 11:45-12:00 Hajime Takeuchi (Tokushima Bunri University): Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells P-109 (S12-S3): 12:00-12:15 Bhagavatula Moorthy (Baylor College of Medicine): Mice deficient in the gene for cytochrome P450 (CYP)1A2 display increased levels of F2-isoprostanes, oxidative DNA adducts, and augmented susceptibility to oxygen-mediated lung injury in vivo Session 13 Steroidogenesis Chairs: Michael R. Waterman, Nobuhiro Harada S13-L1: 9:00-9:30 Kjell Wikvall (Uppsala University): Regulation of CYP enzymes in steroidogenesis with particular focus on cholesterol metabolism and vitamin D-related processes S13-L2: 9:30-10:00 Marion Sewer (Georgia Institute of Technology): Protein kinase C regulates CYP17 transcription by mediating the phosphorylation of steroidogenic factor-1 S13-L3: 10:00-10:30 Michael R. Waterman (Vanderbilt University School of Medicine): Development of CYP51 inhibitors in protozoa 10:30-11:00 (Coffee Break) S13-L4: 11:00-10:30 Nobuhiro Harada (School of Medicine, Fujita Health University): Multiple transcription factors regulate a brain-specific promoter activity of mouse aromatase (CYP19A1) gene S13-L5: 10:30-12:00 Evan Simpson (Prince Henry's Institute of Medical Research): Obesity, P-112 (S13-S1): 12:00-12:15 Hiroshi Kataoka (University of Tokyo): Cytochrome P450s involved in biosynthesis of ecdysteroids in insects; regulation of gene expression by neuropeptides P-113 (S13-S2): 12:15-12:30 Robert Tuckey (University of Western Australia): Metabolism of substrates incorporated into phospholipid vesicles by 25-hydroxyvitamin D3 1α-hydroxylase (CYP27B1) P-114 (S13-S3): 12:30-12:45 Tadashi Ogishima (Kyushu University): Local steroidogenesis in pancreatic P-115 (S13-S4): 12:45-13:00 Maamar Souidi (Institute for Radiological Protection and Nuclear Safety): Testicular steroidogenesis in adult rats following chronic exposure to 137 Cesium since uterine life or birth Oral presentation canceled 13:00~14:30 ~Lunch~ 14:30~15:30 ~Poster award and Closing~

Source: http://enzyme13.bt.a.u-tokyo.ac.jp/icc2009/Speakers0617.pdf

Microsoft word - ohio pharmacy release final.doc

WAL-MART BRINGS $4 GENERIC PROGRAM TO OHIO Customer demand leads to $4 prescription program launching in 12 new states today – three months earlier than projected BENTONVILLE, Ark. – Oct. 26, 2006 – Wal-Mart Stores, Inc. (NYSE: WMT) announced that its 158 stores in Ohio will begin participating in Wal-Mart’s $4 generic prescription program starting today. “No one in Ohio should

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