Standort in Deutschland, wo man günstige und qualitativ hochwertige Kamagra Ohne Rezept Lieferung in jedem Teil der Welt zu kaufen.

Kaufen priligy im Online-Shop. Wirkung ist gut, kommt sehr schnell, innerhalb von 5-7 Minuten. propecia was nur nicht versucht, verbrachte eine Menge Geld und Nerven, und geholfen hat mir nur dieses Tool.

Coexistence of a systemic lupus erythematosus and porphyria
cutanea tarda: case successfully improved by avoidance of sun
Junko Murata, Tadamichi Shimizu, Yasuyuki Tateishi, Riichiro Abe and Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo 060-8638, Japan. Reprint requests to: Tadamichi Shimizu, Department of Dermatology,
Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo Keywords: systemic lupus erythematosus, porphyria cutanea tarda A 46-year-old Japanese woman presented with vesicles on her nose and the dosal aspect of her hands since 3 months. Physical examination revealed tense blisters and atrophic erythematous plaques on her arms and the dosal side of her hands (Fig. 1a). Erosions were also scattered on the face (Fig. 1b). She also had hypertrichosis on her face. The patient was first diagnosed as having systemic lupus erythematosus (SLE) in 1997 at the age of 41 years, when she presented with alopecia, fever, arthralgia, Raynaud’s phenomenon, hemolytic anemia and lymphadenopathy. Liver transamirase levels were slightly elevated. She had no sign of hepatitis including autoimmune hepatitis, drug-related hepatotoxity, alcoholic hepatitis, or viral infection. Systemic lupus eryhtematosus was well-controlled with a At age of 43 years she developed erythematous plaques with scaling on the back of her hands. Clinically the skin erupution at that time appeared to be discoid lupus erythematodes. She was treated with a steroid ointment and her eruptions gradually improved, but new skin lesions repeatedly Laboratory investigations at age 46 years while taking PSL 5mg disclosed the following results: white cell count 3.9 10 9/l. Liver function profile included total bilirubin was 1.7 mg/dl, GOT 46 IU/l, GPT 82 IU/l, γ-GTP 142 IU/l and alkaline phosphatase 456 IU/l. Renal function and electrolytes were normal. Antinuclear antibody (ANA) titers were positive at a dilution of 1/80 (normal value,1/40) with a homogeneous pattern. Histopathological examination of the back of the hands demonstrated a subepidermal blister with slight inflammatory infiltrate. No eosinophilic deposit around the vessels and little edematous change was present in the dermis. (Fig. 2). Direct immunofluorescence revealed a granular fashion at the dermoepidermal junction (DEJ) with IgG, IgM, and C3. Deposition of C3 around the blood vessels and several clusters of colloid bodies associated with IgM were also observed in the upper dermis. Laboratory value of fractionated porphyrins in her urine revealed the following: uroporphyrin 1080 µg/l (normal:<20), coproporophrin 110 µg/l (normal <100), porphobironogen 1.3 mg/l (normal <2), and δ-aminolevulinic acid 3.5 mg/dl. The value of porphyrins in her serum was within the normal range, confirming the diagnosis of PCT. Subsequently, she was treated with topical steroid ointment, and avoidance of sun exposure was implemented. Three months later the value of uroporphyrin and coproporphirin in her urine was almost normal and no Since the association of SLE and PCT was first described by Linden in 1954 (1), approximately 50 cases of LE (all variants) have been described in association with PCT, including 15 cases reported by Gibson and McEvoy (2). PCT results from decreased activity of uroporphyrinogen decarboxylase (UROD). Alcohol, oral contraceptives, polychlorinated hydrocarbons, disturbances of iron metabolism, hepatitis C and infection with HIV are recognized as precipitant factors for PCT (3). Approximately 80 % of PCT patients have the sporadic form in which UROD deficiency is restricted to the liver and the remainder has the familial type in which mutations in the UROD gene are inherited in an autosomal dominant pattern (4). It is not known whether the association between PCT and LE is coincidental or represents some common link. Harris et al. have suggested possible explanations for the coexistence of LE and porphyria: a common genetic abnormality, porphyria triggering an autoimmune response, preexisting LE resulting in an acquired metabolic fault leading to porphyria, and LE precipitating a genetically determined metabolic fault resulting in porphyria (5). It is interesting that the gene for UROD is located on chromosome 1 (6), and that the 1q41-q42 region of that chromosome is Our patient did not drink much alcohol, take oral contraceptives, nor had any blood transfusions. She did not have HCV or HIV infections. Her liver function test was abnormal, and therefore dysfunction of her liver caused by SLE may have been a factor in precipitating the PCT. She has suffered from hemolytic anemia since 1997, so an overload of iron may have caused liver dysfunction and could also have precipitated the PCT. The histological findings of the subepidermal blistering are compatible with PCT, and positive immunofuluorescence staining at the DEJ may have been caused by the Association of SLE and PCT is not common, and this combination usually poses practical problems and occasionally therapeutic dilemmas. Phlebotomy is one treatment for PCT, but it is not advisable in LE patients who have anemia. Antimalarials are used for the treatment of LE and PCT. Severe toxicity can result from using high dose of chloroquine(8), and hydroxichloroquine may also be associated with abdominal crises in some cases. (9). However, low-dose chloroquine therapy has been shown to be effective without causing serious hepatotoxicity(10). Therefore, it is important to avoid high-dose chloroquine therapy in cases of joint LE and Our patient’s skin lesion and the quantity of porphyrines in her urine have been improved since she started the avoidance of sun exposure together with the topical steroid ointment treatment. Strict total sun protection should be recommended to patients with PCT and SLE because both conditions can be activated by long wavelength light bound in sunlight. REFERENCES
1. Linden IH, Steffen CG, Newcomer VD, et al. Development of porphyria during chloroquine therapy for choronic discoid lupus erythmatosus. Calif 2. Gibson GE, McEvoy MT. Coexistence of lupus erythematosus and porphyria cutanea tarda in fifteen patients. J Am Acad Dermatol 3 O’Connor WJ, Murphy GM, Darby C, et al. Porphyrin abnormalities in acquired immunodeficiency syndrome. Arch Dermatol 1996;132:1443-1447 4. Elder GH. Porphyriacutanea tarda. Semin Liver Dis 1998;18:67-75 5. Harrris MY, Mills GC, Levin WC. Coexistent systemic lupus erythematosus and porphria. Arch Intern Med 1966;117:425-428 6. Wu C, Xu W, Kozack CA, et al. Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping. Mamm 7. Tsao BP, Cantor RM, Kalunion KC et al. Evidence for linkage of a candidate chromosome I region for human systemic lupus erythematosus. J Clin Invest 1997;99:725-731 8. Felsher BF, Redeker AG. Effect of chloroquine on hepatic uroporphrin metabolism in patients with porphyria cutanea tarda. Medicine 9. Koranda FC. Antimalarials. J Am Acad Dermatol 1981,4: 650-655 10. Taljaard JJF, Shanley BC, Stewart-Wynne EG, et al. Studies on low dose choloroquine therapy and the action of chloroquine in symptomatic porphria.Br J Dermatol 1972;87:261-269 LEGENDS FOR FIGURES
Fig 1. (a) Right hand with a tense blister, erosions and several pigmented
lesions. (b) Numerous erosions on the face.
Fig 2. Subepidermal blister with slight inflammatory infiltrate. No
eosinophilic deposit are observed around the vessels and few edematous change were present in the dermis.(H&E Murata et al.
Murata et al.


No job name

(C) Tax Analysts 2010. All rights reserved. Tax Analysts does not claim copyright in any public domain or third party content. It’s Not Just Academic: The OECD Should ReevaluateTransfer Pricing Lawsby Michael C. DurstMichael C. Durst is a tax lawyer practicing in Washington, and during the mid-1990s served as director ofthe Advance Pricing Agreement Program, the Internal Revenue Service adv

Handbook 201


Copyright © 2010-2014 Internet pdf articles