Contra-Indications, Warnings etc.
Fortekor 2.5:
For animal treatment only. For oral use only. Wash hands Palatable beige, ovaloid tablets which are scored on both In man, the combination of ACE inhibitors and NSAIDS 2.5 mg benazepril hydrochloride (Fortekor® 2.5).
can lead to reduced antihypertensive efficacy or impaired Fortekor 5 and 20:
renal function. Therefore concurrent use of NSAIDS Ovaloid, biconvex film-coated tablets which are scored Dogs
Transient signs of hypotension such as tiredness or 5 mg benazepril hydrochloride (Fortekor® 5).
Marked “CG” on one side and “LV” on the reverse.
Interactions with potassium preserving drugs, like spironolactone, triamteren or amilorid cannot be ruled 20 mg benazepril hydrochloride (Fortekor® 20).
out. It is recommended to monitor plasma potassium Marked “CG” on one side and “HP” on the reverse.
levels when using benazepril in combination with a potassium sparing diuretic. As with other ACE inhibitors, Fortekor is indicated for the treatment of heart failure in the use of hypotensive medicinal products or anaesthetics dogs and chronic renal insufficiency in cats. The active with a hypotensive effect may add to the anti-hypertensive ingredient is benazepril. After oral administration, bena- effect of benazepril. Fortekor is not recommended for zepril is rapidly absorbed from the gastrointestinal tract breeding dogs, pregnant or lactating bitches. As is and hydrolysed into benazeprilat, a highly specific and routine in cases of renal insufficiency, it is recommended potent inhibitor of angiotensin converting enzyme (ACE).
to monitor plasma urea and creatinine concentrations.
Fortekor produces significant inhibition of plasma ACE Do not use in any dog that has evidence of cardiac activity for more than 24 hours after a single dose in cats output failure due to aortic stenosis.
and dogs. Inhibition of ACE leads to reduced conversion Cats
of inactive angiotensin I into angiotensin II and therefore Fortekor may increase plasma creatinine concentrations reduction in the effects mediated by angiotensin II, in- at the start of the therapy. This effect is related to the cluding vasoconstriction of both arteries and veins and therapeutic effect of the product in reducing blood retention of sodium and water by the kidney. In dogs with pressure and therefore is not necessarily a reason to stop heart failure, Fortekor lowers the blood pressure and therapy in the absence of other signs. As is routine in cases of renal insufficiency, it is recommended to monitor Fortekor leads to a significant extension of the life span of plasma urea and creatinine concentrations and dogs with heart failure and also improves clinical signs, notably reduction in coughing and improvement of the Fortekor reduced erythrocyte counts in normal cats at quality of life. In contrast with other ACE inhibitors, bena- high doses, but this effect was not observed at the zeprilat is excreted equally by both biliary and urinary recommended dose during clinical trials in cats with routes in dogs and primarly via the biliary route in cats chronic renal insufficiency. Fortekor may increase food and therefore no adjustment of the dose of Fortekor is consumption and body weight in cats. The combination necessary in the treatment of cases with renal insufficien- of Fortekor and other anti-hypertensive agents cy. In cats with chronic renal insufficiency, Fortekor redu-ces the protein loss in urine and lowers the systemic and (e.g. calcium channel blockers, -blockers or diuretics), intraglomerular blood pressure. Fortekor increases the anaesthetics or sedatives may lead to additive appetite, quality of life and the survival time of the cats, Fortekor is not recommended for breeding cats, pregnantor lactating queens. The safety and efficacy of Fortekor Dosage and Administration
has not been established in cats below 2.5 kg.
Heart failure in dogs
The recommended dose is 0.25–0.5 mg benazepril
Pharmaceutical Precautions
hydrochloride/kg body weight, to be given orally once Store in a dry place. Do not store above 25 ºC. Each time an unused half tablet is stored, it should be returned tothe open blister space, inserted back into the cardboard Fortekor 5
box and kept in a safe place out of reach of children.
Legal Category: POM – Prescription Only Medicine
Package Quantities
Plastic blister packs each containing 14 tablets: • Individual pack containing 1 blister (Fortekor 5, • Pack containing 2 blisters (Fortekor 2.5) Fortekor 20
Further Information
No evidence of renal toxicity to Fortekor has been observed in dogs during clinical trials. The biliary excretion of benazepril means there is little risk of bioaccumulation in dogs and cats with impaired renalfunction.
Dispose of used packaging in the household refuse.
Fortekor can be given with or without food. The duration Unused product should be returned to the veterinary of treatment is unlimited. The dose may be doubled, still administered once daily, if judged clinically necessaryand advised by the veterinary surgeon. When the 10 mgdose is required, veterinary surgeons should consideradministering two 5 mg tablets to limit the use of halftablets.
Fortekor may be given in combination with digoxin, Manufacturer of the medicinal product
diuretics and anti-arrhythmic drugs as necessary.
Novartis Santé Animale SA, 26, rue de la chapelle Chronic renal insufficiency in cats
The recommended dose is 0.5–1.0 mg benazepril Marketing Authorisation Numbers in UK
hydrochloride/kg body weight, to be given orally once Fortekor 2.5
Fortekor 5
Novartis Animal Health UK Limited, New Cambridge House, Litlington, Nr. Royston, Hertfordshire SG8 0SS Fortekor can be given with or without food.
The duration of the treatment will be unlimited.
21709 - UK - PP - Fortekor - 163x297 mm - Black

Source: http://www.felinegood.co.uk/docs/21709_uk_fortekor_all.pdf


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