Microsoft word - cv_fml_imm_ana sebastiao25.doc

Place and Date of Birth: 15th March 1958 Institutional
Instituto de Farmacologia e Neurociências Instituto de Medicina Molecular (IMM) Edifício Egas Moniz Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal Telephone: +(351) 21 798 5183 Fax: +(351) 21 799 9454 Email: anaseb@fm.ul.pt Academic
Aggregation in Neurosciences, Faculdade de Medicina da Universidade PhD in Biochemistry and Cell Physiology, Universidade Nova de Lisboa Undergraduate Degree in Biology, Universidade de Lisboa Present Position
Associate Professor with aggregation, Faculdade de Medicina de Lisboa Scientific
Associate Professor Faculdade de Medicina de Lisboa 1997- 2004
Auxiliary Professor, Faculdade de Medicina de Lisboa 1992 -1997
Researcher, Instituto Gulbenkian de Ciência 1989 - 1992
Assistant Researcher, Instituto Gulbenkian de Ciência 1986 - 1989
Assistant Researcher, Instituto Gulbenkian de Ciência 1982 - 1986
PhD Studentship, Instituto Gulbenkian de Ciência 1980 - 1981
Undergraduate Internship, Centro de Estudos Egas Moniz Specialty

Other Areas of
Interest

Neuromodulation of synaptic transmission, in particular at the hyppocampus. Research Area
Interactions between neuromodulatoras, focusing on neurotrophins, adenosine, neuropeptides and cannabinoids. Neuroprotection. Adenosine receptors and adenosine transporters. G-protein coupled receptors and kinase receptors Coordination of
International Projects
Externally
2005-2009
Participant as group leader of a COST Concerted Action on Neural Research
Projects
1996 - 1998
Coordinator of the Portuguese team of the project BMH4-CT96-
0676, "Nucleotides, a novel class of extracellular signalling
substances in the nervous system" supported by the BIOMED II
programme (EU). General coordinator: H. Zimmermann, Univ. Frankfurt. Other local coordinators: M.P. Abbrachio, Univ. Milão; G. Burnstock, University College, London; E Heilbronn, Univ. Stockholm; M.T. Miras-Portugal, Univ. Complutense de Madrid; K. Starke, Univ. Freiburg. 1989 - 1990
General coordinator of the EU Research grant of the "Biotechnology
Action Programme", BAP-0470P-EDP, "In vitro evaluation of the
pharmacological activity of analogues of adenine nucleotides and adenosine: structure activity requirements of ectonucleotidases".
National Projects
2005/2008
General corrdinator of the project ‘Neurotrophins and neuronal
communication: fine tuning by adenosine.
POCTI/SAU/56332/2004. Supported by FCT (Portugal).
2003 - 2006
General coordinator of the project POCTI/37398/NSE/2001
"Modulation of synaptic transmission in interneurones: Role of
adenosine". Supported by FCT (Portugal).
1999 - 2002
General coordinator of the project SAU/14012/1998 "Role of A2A
receptors in the hippocampus: modulation of neuromodulators?" 1996 - 1998
Coordinator at Institution 1 of the project
PRAXIS/2/2.1/BIA/137/94, "Interacções entre adenosina e
neuropeptidos no sistema nervoso". Supported by FCT (Portugal). 1993 - 1995
General coordinator of the project STRD/SAU/292/92
"Neuromodulação pela adenosina no hipocampo". Supported by FCT
Organization
Member of the Organizing Committee of the EPHAR Meeting, Porto, Portugal, 2004. of International
Meetings
Member of the Organizing Committee of the FENS Biannual Meeting, Lisbon, Portugal, Member of the Scientific Organizing Committee of the FENS Summer School on Purines and Neuronal Communication, Ofir, Portugal, July 2001. Member of the Organizing Committee of the 3rd International Symposium of Nucleosides and Nucleotides, Madrid, July 2000. Workshop on 'Release and extracellular metabolism of adenine nucleotides and adenosine in the nervous system'. 14th International Society for Neurochemistry Biennial Meeting, Montpellier, France, 1993. Round Table on 'Adenosine formation and transport in nerve cells'. 12th International Society for Neurochemistry Biennial Meeting, Albufeira, Portugal, 1989. Scientific
Positions
Societies
2003 – Present Member of the Executive Committee of the European Federation of
2003 – Present President of the 'Sociedade Portuguesa de Neurociências'
2001 – 2003
President of the 'Sociedade Portuguesa de Farmacologia' 1999 – 2003
Vice-President of the 'Sociedade Portuguesa de Neurociências' 1998 – 2001
Vice-President of the 'Sociedade Portuguesa de Farmacologia' 1993 – 1996
General Secretary of the 'Sociedade Portuguesa de Neurociências' 1992 – 1998
Vice-President of the 'Sociedade Portuguesa de Neuroquímica'
Memberships
International Societies
Society for Neuroscience – since 1997 British Pharmacological Society – since 1988 International Society for Neurochemistry – since 1987 Society for Experimental Biology – 1994 – 1997 Sociedade Portuguesa de Neurociências: Founding Partner and Member (1992) Sociedade Portuguesa de Farmacologia: since 1984 Sociedade Portuguesa de Neuroquímica: 1985 - 2001 Sociedade Portuguesa de Bioquímica: 1985 - 2001 Associação Portuguesa de Biólogos: 1992 - 2001 Sociedade Portuguesa de International
Collaborations
M.T. Miras-Portugal (Univ. Complutense Madrid) E.S. Vizi (Hungarian Acad. Sci., Budapest) Editorial Activity
2003 - Present - Member of the Editorial Board of the Journal of Neurochemistry. Of Papers in International Journals
Journal of Neuroscience
Journal of Neuroendocrinology
British Journal of Pharmacology
European Journal of Neuroscience European Journal of Pharmacology Life Science Behavioural Brain Research Neuroscience Letters Journal of Neurochemistry
Of Scientific projects

1996, 1999, 2001, 2005 - INTAS (Associação internacional de cooperação entre a União
Europeia e os países de Leste).
1996 - The Neuro Oncology Foundation
1995 - JNICT


Publications
Full papers in refereed Journals
1. CUNHA-REIS, D., RIBEIRO, J.A. and SEBASTIÃO, A.M. VPAC2 receptor activation
mediates VIP enhancement of population spikes in the CA1 area of the hippocampus. 2. CUNHA-REIS, D., RIBEIRO, J.A. and SEBASTIÃO, A.M. (2005) VIP enhances
synaptic transmission to hippocampal CA1 pyramidal cells through activation of both
VPAC1 and VPAC2 receptors. Brain Res. 1049, 52-60.
3. PINTO-DUARTE, A., COELHO, J.E., CUNHA, R.A., RIBEIRO, J.A. and SEBASTIÃO,
A.M. (2005). Adenosine A2A receptors control the extracellular levels of adenosine
through modulation of nucleoside transporters activity in the rat hippocampus. J.
Neurochem. 93, 595-604.
4. CUNHA-REIS, D., SEBASTIÃO, A.M., WIRKNER, K, ILLES, P. and RIBEIRO, J.A.
(2004). VIP enhances both pre- and post-synaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells. Br. J. Pharmacol. 143, 733-744.
5. CANAS, N., PEREIRA, I.T., RIBEIRO, J.A. & SEBASTIÃO, A.M. (2004) Brain-derived
neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal
synaptosomes through different mechanisms. Brain Res. 1016, 72-78.
6. DIÓGENES, M.J., FERNANDES, C.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2004)
Activation of adenosine A2A receptor facilitates BDNF modulation of synaptic transmission in hippocampal slices. J. Neurosci., 24, 2905-2913.
7. RIBEIRO, J.A., LOBO, M.G. & SEBASTIÃO, A.M. (2003). Endogenous adenosine modulation of 22Na uptake by rat brain synaptosomes. Neurochem Res., 28, 1589-
1593.
8. REBOLA, N., SEBASTIÃO, A.M., de MENDONÇA, A., OLIVEIRA, C.R., RIBEIRO, J.A. & CUNHA, R.A. (2003). Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. J. Neurophysiol. 90, 1295-1303.
9. RIBEIRO, J.A., SEBASTIÃO, A.M. & de MENDONÇA, A. (2003). Adenosine receptors
in the nervous system: pathophysiological implications. Prog. Neurobiol. 68, 377-
392.
10. RIBEIRO, J.A., SEBASTIÃO, A.M. & de MENDONÇA, A. (2003). Participation of
adenosine receptors in neuroprotection. Drug News and Prespectives, 16, 80-86.
11. CASCALHEIRA, J.F., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2002). Pertussis toxin-
sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism
caused by adenosine A1 receptors in rat hippocampal slices. Neurochem. Res., 27,
1707-1711.
12. CUNHA, R.A., COELHO, J.E., COSTENLA, A.R., LOPES, L.V., PARADA, A., DE MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2002). Effects of
carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]Azepine-5-carboxamide
derivatives on synaptic transmission in rat hippocampal slices. Pharmacol. &
Toxicol., 90, 208-213.
13. SEBASTIÃO, A.M., de MENDONÇA, A., MOREIRA, T. & RIBEIRO, J.A. (2001).
Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on
reoxygenation. J. Neurosci., 21, 8564-8571.
14. SEBASTIÃO, A.M., CUNHA, R.A. DE MENDONÇA, A. & RIBEIRO, J.A. (2001).
Modification of adenosine modulation of synaptic transmission in the hippocampus of
aged rats. Br. J. Pharmacol., 131, 1629-1634.
15. SEBASTIÃO, A.M., de MENDONÇA, A. & RIBEIRO, J. A. (2001). Neuroprotection
during hypoxic insults: role of adenosine. Drug Development Research, 52, 291-
295.
16. RIBEIRO, J.A., CUNHA-REIS, D., LOPES, L.V., COELHO, J.E., COSTENLA, A.R., CORREIA-DE-SÁ, P., CUNHA, R.A., de MENDONÇA, A. & SEBASTIÃO, A.M. (2001).
Adenosine receptor interactions in the hippocampus. Drug Development
Research, 52, 337-345.
17. SEBASTIÃO, A.M., MACEDO, M.P. & RIBEIRO, J.A. (2000). Tonic activation of A2A
adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. Br. J. Pharmacol., 129,
374-380.
18. SEBASTIÃO, A.M. & RIBEIRO, J.A. (2000). Fine tuning neuromodulation by
adenosine. Trends in Pharmacological Sciences, 21, 341-346.
19. de MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2000). Adenosine: does it have a neuroprotective role after all? Brain Research Reviews, 33, 258-274.
20. Costenla, A.R., de Mendonça, A., Sebastião, A.M. & Ribeiro, J.A. (1999). An
adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of
the rat retina. Exp. Eye Res., 68, 367-370.
21. Sebastião. A.M., Cunha, R.A., Cascalheira, J.F., & Ribeiro, J.A. (1999). Adenine
nucleotides as inhibitors of synaptic transmission: role of localised ectonucleotidases. Prog. Brain Res., 120, 183-192.
22. Cunha, R.A., Sebastião, A.M. & Ribeiro, J.A. (1998). Inhibition by ATP of
hippocampal synaptic transmission requires localized extracellular catabolism by
ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. J.
Neuroscience,.18, 1987-1995.
23. Cascalheira, J.F. & Sebastião, A.M. (1998). Adenosine A1 receptor activation inhibits
basal accumulation of inositol phosphates in the rat hippocampus. Pharmacol. &
Toxicol., 82,.189-192.
24. Lorenzen, A., Sebastião, A.M., Sellink, A., Vogt, H., Ulrich, Schwabe, Ribeiro, J.A. &
Ijzerman, A.P.1 (1997). Biological activities of N6-substituted adenosine derivatives
as partial agonists of rat brain adenosine receptores, Eur. J. Pharmacol., 334, 299-
307.
25. Lobo, M.G., Oliveira, D.G., Sebastião, A.M. & Ribeiro, J.A. (1997). On the high
affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor
present in rat motor nerve terminals. Pharmacol. & Toxicol., 80, 295-300
26. RIBEIRO, J.A., de MENDONÇA, A. CORREIA-DE-SÁ, P., CUNHA, R. & SEBASTIÃO,
A.M. (1996). Purinoceptors and synaptic plasticity. Drug Develop. Res., 39,.353-
360.
27. CUNHA, R.A., VIZI, E.S., RIBEIRO, J.A. & SEBASTIÃO, A.M. (1996). Release of ATP
and its extracellular catabolism as a source of adenosine upon high and low
frequency stimulation of rat hippocampal slices. J. Neurochem., 67, 2180-2187.
28. AFONSO, F., SEBASTIÃO, A.M., PINHO, M.S., FERNANDES, P., RIBEIRO, J.A.,
MATA, L.R. & GULBENKIAN, S. (1996). Calcitonin gene-related peptide in the hamster seminal vesicle and coagulating gland. Immunohistochemical, autoradiographical and pharmacological study. Peptides, 17, 1189-1195.
29. CUNHA, R.A., CORREIA-DE-SÁ, P., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1996)
Preferential activation of excitatory adenosine receptors at rat hippocampal and
neuromuscular synapses by adenosine formed from released adenine nucleotides.
Br. J. Pharmacol., 119, 253-260.
30. LUCCHI, R., LATINI, S., de MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(1996). Adenosine by activating A1 receptors prevents GABAA-mediated actions during hypoxia in the rat hippocampus. Brain Res., 732, 261-266.
31. CUNHA, R.A., JOHANSSON, B., CONSTANTINO, M.D., SEBASTIÃO, A.M. &
FREDHOLM, B.B. (1996). Evidence for high affinity binding sites for the A2A receptor agonist, [3H]CGS21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn-Schmiedeberg’s Arch. Pharmacol., 353,
32. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1996). A2 receptor mediated excitatory actions
of adenosine in the nervous system. Prog. Neurobiol., 48, 167-189.
33. RIBEIRO, J.A., CUNHA, R.A., CORREIA-DE-SÁ, P. & SEBASTIÃO, A.M. (1996).
Purinergic regulation of acetylcholine release. Prog. Brain Res. 109, 232-241.
34. CUNHA, R.A., CONSTANTINO, M.D., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1995).
Modification of A1 and A2a receptor binding in aged striatum, hippocampus and
cortex of the rat. NeuroReport, 6, 1583-1588.
35. CUNHA; R.A., JOHANSSON, B., FREDHOLM, B.B., RIBEIRO, J.A. & SEBASTIÃO, A.M.
(1995). Adenosine A2a receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci. Letts, 196, 41-44.
36. de MENDONÇA, A., SEBASTIÃO, A.M. and RIBEIRO, J.A. (1995). Inhibition of NMDA
receptor-mediated currents in isolated rat hippocampal neurons by adenosine A1
receptor activation. NeuroReport, 6, 1097-1100.
37. OLIVEIRA, J.C., CONSTANTINO, M.D., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1995).
Ascorbate/Fe3+-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes. Neurochem. Int., 26, 263-268.
38. CUNHA, R.A., JOHANSSON, B., van der PLOEG, I., SEBASTIÃO, A.M., RIBEIRO, J.A.
& FREDHOLM, B.B. (1994). Evidence for functionally important adenosine A2a
receptors in the rat hippocampus. Brain Res., 649, 208-216.
39. CUNHA, R.A., MILUSHEVA, E., VIZI, E.S., RIBEIRO, J.A. & SEBASTIÃO, A.M.
(1994). Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically-evoked [3H]-acetylcholine release from different areas of the rat hippocampus. J. Neurochem., 63, 207-214.
40. PINHO, M.S., SEBASTIÃO, A.M., RODRIGUES, G., BARROSO, C.P., RIBEIRO, J.A.,
MATA, L.R. & GULBENKIAN, S. (1994). Vasoactive intestinal peptide (VIP) in the hamster seminal vesicle: distribution, binding sites and possible functions. Neuroscience, 59, 1083-1091.
41. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1994). Purinergic modulation of
the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of
the rat: role of the ectonucleotidases. Eur. J. Neurosci., 6, 33-42.
42. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1994). Further evidence for A3 adenosine
receptors. Trends in Pharmacol.Sci.
43. OLIVEIRA, J.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1993). On the high affinity
binding site for [3H]-1,3-dipropyl-8- cyclopentylxanthine in frog brain membranes.
Br. J. Pharmacol., 109, 518-523.
44. CUNHA, R.A. & SEBASTIÃO, A.M. (1993). Adenosine and adenine nucleotides are
independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog. Pflugers Archiv.,
424, 503-510.
45. CASCALHEIRA, J.F. & SEBASTIÃO, A.M. (1992). Adenine nucleotide analogues,
including .-phosphate-substituted analogues, are metabolised extracellularly in
innervated frog sartorius muscle. Eur. J. Pharmacol., 222, 49-59.
46. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1992). Evidence for the presence of excitatory
A2 adenosine receptors in the rat hippocampus. Neurosci. Letts, 138, 41-44.
47. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1992). Ecto-5'- nucleotidase is
associated with cholinergic nerve terminals in the hippocampus but not in the
cerebral cortex of the rat. J. Neurochem., 59, 657-666.
48. CUNHA, R.A. & SEBASTIÃO, A.M. (1991). Extracellular metabolism of adenine
nucleotides and adenosine at the innervated skeletal muscle of the frog. Eur. J.
Pharmacol., 197, 83-92.
49. CORREIA-DE-SA, P., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1991). Inhibitory and
excitatory effects of adenosine receptor agonists on evoked transmitter release from
phrenic nerve endings of the rat. Br. J. Pharmacol., 103, 1614-1620.
50. OLIVEIRA, J.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1991). Solubilized rat brain
adenosine receptors have two high affinity binding sites for 1,3-dipropyl-8- cyclopentylxanthine. J. Neurochem., 57, 1165-1171.
51. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1991). Purinergic modulation of
neurotransmitter release in the peripheral and central nervous systems. In:
Presynaptic Regulation of Neurotransmitter release, A Handbook., ed. J.
Feigenbaum and M. Hanani, pp.451-495, Freund, London.
52. SEBASTIÃO, A.M., STONE, T.W. & RIBEIRO, J.A. (1990). On the inhibitory
adenosine receptor at the neuromuscular junction and hippocampus of the rat:
antagonism by 1,3,8-substituted xanthines. Br.J.Pharmacol., 101, 453-459.
53. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1990). Interactions between adenosine and
phorbol esters or lithium at the frog neuromuscular junction. Br.J.Pharmacol., 100,
55-62.
54. DELICADO, E.G., RODRIGUES, A., SEN, R.P., SEBASTIÃO, A.M., RIBEIRO, J.A. &
MIRAS-PORTUGAL, M.T. (1990). Effect of N- ethylcarboxamidoadenosine (NECA) on
adenosine transport in cultured chromaffin cells. J.Neurochem., 54, 1941-1946.
55. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1989). Separation of adenosine
triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography. Chromatographia, 28,
610-612.
56. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1989). 1,3,8- and 1,3,7- substituted xanthines:
relative potency as adenosine receptor antagonists at the frog neuromuscular
junctions. Br.J.Pharmacol., 96, 211-219.
57. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1988). On the adenosine receptor and
adenosine inactivation at the rat diaphragm neuromuscular junction.
Br.J.Pharmacol., 94, 109-120.
58. SIMÕES, A.P., OLIVEIRA, P.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1988). N6-
cyclohexyladenosine inhibits veratridine- stimulated 22Na uptake by rat brain
synaptosomes. J.Neurochem., 50, 899-903.
59. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1988). Is inhibition of neurotransmitter release
mediated by A3 receptors? Subtypes of adenosine receptors. Trends in
Pharmacol.Sci., 9, 279-280.
60. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1987). On the role, inactivation and origin of
endogenous adenosine at the frog neuromuscular junction. J.Physiol.Lond., 384,
571-585.
61. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1986). Adenosine receptors and calcium: basis
for proposing a third (A3) adenosine receptor. Prog.Neurobiol., 26, 179-209.
62. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1985). Enhancement of transmission at the frog
neuromuscular junction by adenosine deaminase: evidence for an inhibitory role of
endogenous adenosine on neuromuscular transmission. Neurosci.Letts., 62, 267-
270.
63. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1985). Inhibitory effects of forskolin and
papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve. Br.J.Pharmacol., 85, 309-313.
64. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1985). On the type of receptor involved in the
inhibitory action of adenosine at the neuromuscular junction. Br.J.Pharmacol., 84,
911-918.
65. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1984). Enhancement of tetrodotoxin-induced
axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic AMP and methylxanthines in the frog sciatic nerve. Br.J.Pharmacol., 83, 485-492.
66. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1984). Antagonism of tetrodotoxin- and
procaine-induced axonal blockade by adenine nucleotides in the frog sciatic nerve.
Br.J.Pharmacol., 81, 277-282.
Other publications in extenso (abstracts excluded)
67. SEBASTIÃO, A.M. (2002) Neuromodulação: controlo subtil da actividade nervosa.
Revista da Faculdade de Medicina de Lisboa, série III, 7, 231-236.
68. SEBASTIÃO, A.M. & RIBEIRO, J.A. (2001; 2006). Sistema Purinérgico. In
Terapêutica Medicamentosa e suas Bases Farmacológicas, ed. W. Osswald & S. Guimarães, pp. 440-450, Porto Editora, Porto. 69. Sebastião, A.M., Lucchi, R., Latini, S., de Mendonça, A. & Ribeiro, J.A. (1996).
Functional negative interaction between adenosine (A1) and GABA (GABAA) during hypoxia in the rat hippocampus. In: The Role of Adenosine in the Nervous
System, ed. Y. Okada, pp. 177-164), Elsevier, Amesterdam.
70. Ribeiro, J.A., Correia-de-Sá, P., Cunha, R.A. & Sebastião, A.M. (1997). Adenosine
and neurotransmitter release: inhibition and facilitation. In: The Role of Adenosine
in the Nervous System, ed. Y. Okada, pp. 13-24, Elsevier, Amesterdam.
71. SEBASTIÃO, A.M., CUNHA, R.A., CORREIA-DE-SÁ, P., de MENDONÇA, A. &
RIBEIRO, J.A. (1995). Role of A2a receptors in the hippocampus and motor nerve endings. In: Adenosine and Adenine Nucleotides: from molecular Biology to
Integrative Physiology, Kluwer Academic Publishers, pp.251-261.
72. RIBEIRO, J.A., CORREIA-DE-SÁ, P., CUNHA, R.A., OLIVEIRA, J.C. & SEBASTIÃO,
A.M. (1991). Role of adenosine at the neuromuscular junction: effects mediated by
presynaptic inhibitory and excitatory receptors. In: Role of Adenosine and
Adenine Nucleotides in the Biological System, ed. S. Imai and M. Nakazawa,
pp.691-702, Elsevier Sci. Publ., Amesterdam.
73. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1990). Adenosine receptors mediating inhibition
of peripheral and central neurons. In: Purines in Cellular Signalling: Targets for
New Drugs, ed. K.A. Jacobson, J.W. Daly and V. Manganiello, pp.166-173, Springer
Verlag, New York.
74. SEBASTIÃO, A.M. (1989). On the transducing mechanism operated by the
adenosine receptor mediating inhibition of transmitter release at the neuromuscular junction. In: Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, pp.
131- 140, Taylor & Francis, London.
75. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1989). Characterization of the adenosine
receptor that mediates inhibition of transmitter release at the frog neuromuscular
junction. In: Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, pp.
69-77, Taylor & Francis, London.
76. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1987). Adenosine, cyclic AMP and nerve
conduction. In: Topics and Perspectives in Adenosine Research, eds. E. Gerlach
and B.F. Becker, pp. 559- 573, Springer-Verlag, Berlin.
Postgraduate
Ph.D. Sypervision
teaching
Natália Assaife Lopes (under progress) Catarina Fernandes (under progress) Maria José Diógenes (under progress) Diana Cunha-Reis (under progress) José Francisco Cascalheira (2003, Ph.D. in Biomedicine, Univ Beira Interior) Rodrigo A. Cunha (1994, Ph.D. in Chemistry, Fac. Ciências, Univ. Lisboa)
Master thesis supervision
Paula Pousinha Luís (2006, Master in Neurosciences, Fac. Med, Univ Lisboa) Nuno Canas (2003, Master in Neurosciences, Fac. Med, Univ Lisboa) António Duarte (2004, Master in Neurosciences, Fac. Med, Univ Lisboa) Isabel Fragata (2004, Master in Neurosciences, Fac. Med, Univ Lisboa)
Basic degree thesis

Sandra Vaz (2004, Biochemistry, Fac. Ciências, Univ Lisboa)
Diana Cunha-Reis (1998, Biochemistry, Fac. Ciências, Univ Lisboa) Ana Rita Costenla (1996, Biology, Fac. Ciências e Tenol. Univ. Coimbra) J.F. Cascalheira (1990, Biochemistry, Fac. Ciências, Univ Lisboa) Rodrigo A. Cunha (1989, Biochemistry, Fac. Ciências, Univ Lisboa) Paula Simões (1988, Biology, Fac. Ciências e Tecnol, Univ Coimbra) Paula Oliveira (1987, Biology, fac. Ciências, Univ. Lisboa)
Intruduction to scientific investigation
Gabriel Oliveira (2004, Fac. Medicina, projecto GAPIC)
Eunice Carrapiço (2004, Fac. Medicina, projecto GAPIC)
Ana Rita Ferreira (2004, Fac. Medicina, projecto GAPIC)
Nicole Cardoso (2004, Fac. Medicina, projecto GAPIC)
Vânia Costa (2004, Fac. Medicina, projecto GAPIC)
Inês Tomás Pereira (2003, Fac. Ciências)
Lectures for postgraduate students
1999/presente – Several lectures in the Master of Neurosciences, Faculty of Medicine,
Uni. Lisboa
2005 - Adenosine Receptors – Seminar at the Institute for Pharmacology and Toxicology,
University of Zurich, a convite de Detlev Boison, Univ. Zurich.
2005 – Lecture on Apoptose on the Master on Neuroophtalmology , Fac. Med. Univ Lisboa. 2004 – Neuromodulation by Adenosine: Key Role of A2a Receptors: Lecture at the European Winter Conference on Brain Research, Les Arcs, a convite de Bruno Frenguelli, University of Dundee. 2003, 2004. 2005 – Lectures on ‘electrophysiological tecniques on the Neurobiology course, Faculdade de Farmácia, Universidade de Lisboa 2001 – Lecture on a FENS Summer school on Purines and Neuroprotection, Ofir. 2001 – Round Table on ‘Novos Horizontes da Neuroquímica’, VIII Forum Farmacêutico – Perturbações Neuroquímicas – o legado da Sociedade Moderna, organizado pela Associação de Estudantes da Fac. Farmácia Univ. Porto, 2001. 1994 – Lectures and Lab teaching at the international workshop ‘Pharmacology of Cell Signalling’. Estudos Avançados de Oeiras, Instituto Gulbenkian de Ciência. 1992 – Seminars at the Master Course on Cellular Biology, Universidade de Coimbra 1987 – Lab Teaching at the international workshop l ‘Membrane Receptors, Transducing Mechanisms and Neurotransmitter Release’, Estudos Avançados de Oeiras, Instituto Gulbenkian de Ciência.
1987 – Seminar on the workshop‘Técnicas em Biologia e Biotecnologia’, Instituto
Gulbenkian de Ciência.

Pregraduate
1998/present –curso livre experimental de Neurociências da Faculdade de Medicina de teaching
Lisboa; responsável pelo curso desde 2005. 1989/1992 - Responsável pela cadeira de Neuroquímica, Licenciatura de Bioquímica da Faculdade de Ciências de Lisboa (a título gracioso e sem vínculo institucional, por sempre ter assumido a função de investigação a tempo inteiro na FCG). 1985/1986 - Seminários sobre receptores, métodos de estudo de receptores e cinética de ligação fármaco-receptor, na cadeira de Farmacologia do Instituto de Ciências Biomédicas 2006 – Coordinator of the session on Drogas e Cérebro (Drugs and the Brain), Pavilhão
Awarteness of
do Conhecimento, Lisboa, on the grounds of the Brain awareness Week, March, a Round table and an interactive exhibition
2005 – Coordinator of the session Música e Cérebro (Miusic and the Brain), Pavilhão do
Conhecimento, Lisboa and Belgais, on the grounds of the Brain awareness Week, March,
a Round table
2005 – Written coment on the paper ‘Age-Related effects of alcohol on Memory-Related Brain Function in Adolescents and Adults, White AM and Swartzwelder HS, published at the Portuguese Journal ‘Cérebro Toxicodependente’, nº2. 2005 – ‘Neurociências – Estudo do Sistema Nervoso’ – Artigo no Dossier ‘Doenças do Sistema Nervoso’, Público, 16 de Abril de 2005 (Comment on a Newspaper) 2005 and 2006 – Sessions on demand at basic and secondary schools on ‘Drogas e Cérebro’ and ‘Como Funciona o nosso Cérebro’, on the grounds of the Brain Awareness Week 2004 - Brain awareness Week in 2004, Portugal – debate numa mesa redonda promovida pela DANA Foundation no FENS 2004 Forum, Lisboa.

Source: http://www.fm.ul.pt/FMLPortal/UserFiles/File/AnaSebastiao.pdf