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Bernard Lardeux
1- Lardeux B, Bourdel G, Girard-Globa A (1978) Regulation of hepatic synthesis of proteins
by the chronology of protein ingestion. Biochim Biophys Acta , 518:113-124.
2- Girard-Globa A, Bourdel G, Lardeux B (1980) Regulation of protein synthesis and
enzyme accumulation in the rat pancreas by amount and timing of dietary protein. J Nutr,

Jarrousse C, Lardeux B, Bourdel G, Girard-Globa A, Rosselin G (1980) Portal insulin and
glucagon in rats fed proteins as a meal: immediate variations and circadian modulations. J
, 110:1764-1773.
4- Lardeux B, Bourdel G, Antoszewska B (1981) Rapid modifications of the rat hepatic
lysosomal system as a function of the nutritional state. Reprod Nutr Dev, 21:303-308.
5- Bourdel G, Hitier Y, Lardeux B, Girard-Globa A (1983) Activity of several enzymes of
amino acid catabolism in the liver of rats fed protein as a meal. Reprod Nutr Dev, 23:875-881.
6- Lardeux B, Gouhot B, Forestier M (1983) Improved recovery of rat liver fractions
enriched in lysosomes by specific alteration of the sedimentation properties of mitochondria.
Anal Biochem, 131:160-165.
7- Maurice M, Lardeux B, De Saint-Steban C, Bourdel G, Feldmann G (1986) Influence of
diets with different levels of protein and energy on liver albumin content in the rat. J Nutr, 116
8- Lardeux BR, Heydrick SJ, Mortimore GE (1987) RNA degradation in perfused rat liver as
determined from the release of [14C]cytidine. J Biol Chem, 262:14507-14513.
9- Lardeux BR, Mortimore GE (1987) Amino acid and hormonal control of macromolecular
turnover in perfused rat liver. Evidence for selective autophagy. J Biol Chem, 262:14514-14519.
10- Mortimore GE, Lardeux BR, Adams CE (1988) Regulation of microautophagy and basal
protein turnover in rat liver. Effects of short-term starvation. J Biol Chem, 263:2506-2512.
11- Lardeux BR, Heydrick SJ, Mortimore GE (1988) Rates of rat liver RNA degradation in
vivo as determined from cytidine release during brief cyclic perfusion in situ. Biochem J,
12- Mortimore GE, Lardeux BR, Heydrick SJ (1989) Mechanism and control of protein and
RNA degradation in the rat hepatocyte: two modes of autophagic sequestration. Revis Biol
. 20:79-96.
13- Mortimore GE, Poso AR, Lardeux BR (1989) Mechanism and regulation of protein
degradation in liver. Diabetes Metab Rev, 5:49-70.
14- Balavoine S, Feldmann G, Lardeux B (1990) Rates of RNA degradation in isolated rat
hepatocytes. Effects of amino acids and inhibitors of lysosomal function. Eur J Biochem,

15- Heydrick SJ, Lardeux BR, Mortimore GE (1991) Uptake and degradation of cytoplasmic
RNA by hepatic lysosomes. Quantitative relationship to RNA turnover. J Biol Chem, 266:8790-
16- Balavoine S, Rogier E, Feldmann G, Lardeux B (1992) Responsiveness of RNA
degradation to amino acids in cultured rat hepatocytes: comparison with isolated rat
hepatocytes. J Cell Physiol, 150:149-157.
17- Balavoine S, Feldmann G, Lardeux B (1993) Regulation of RNA degradation in cultured
rat hepatocytes: effects of specific amino acids and insulin. J Cell Physiol, 156:56-62.
18- Maurice M, Schell MJ, Lardeux B, Hubbard AL (1994) Biosynthesis and intracellular
transport of a bile canalicular plasma membrane protein: studies in vivo and in the perfused
rat liver. Hepatology, 19:648-655.
19- Bleiberg-Daniel F, Lamri Y, Feldmann G, Lardeux B (1994) Glucagon administration in
vivo stimulates hepatic RNA and protein breakdown in fed and fasted rats. Biochem J, 299:645-
20- Barraud B, Balavoine S, Feldmann G, Lardeux B (1995) Effects of nicotinamide on
hepatocyte viability and secretion of albumin and alpha 1-acid glycoprotein by adult rat
hepatocytes in primoculture. Comparison with dexamethasone and recombinant human
interleukin-6. Biol Cell , 83:127-133.
21- Kaabache T, Barraud B, Feldmann G, Bernuau D, Lardeux B (1995) Direct solution
hybridization of guanidine thiocyanate-solubilized cells for quantitation of mRNAs in
hepatocytes. Anal Biochem, 232:225-230.
22- Barraud B, Balavoine S, Feldmann G, Lardeux B (1996) Effects of insulin,
dexamethasone and cytokines on alpha 1-acid glycoprotein gene expression in primary
cultures of normal rat hepatocytes. Inflammation, 20:191-202.
23- Saadane A, Neveux N, Feldmann G, Lardeux B, Bleiberg-Daniel F (1996) Inhibition of
liver RNA breakdown during acute inflammation in the rat. Biochem J, 317:907-912.
24- Nadori F, Lardeux B, Rahmani M, Bringuier A, Durand-Schneider AM, Bernuau D
(1997) Presence of distinct AP-1 dimers in normal and transformed rat hepatocytes under
basal conditions and after epidermal growth factor stimulation. Hepatology, 26:1477-1483.
25- Tordjmann T, Berthon B, Lardeux B, Moreau A, Jacquemin E, Combettes L, Feldmann
G, Claret M (1997) An improved digitonin-collagenase perfusion technique for the isolation
of periportal and perivenous hepatocytes from a single rat liver: physiological implications for
lobular heterogeneity. Hepatology, 26:1592-1599.
26- Crestani B, Rolland C, Lardeux B, Fournier T, Bernuau D, Pous C, Vissuzaine C, Li L,
Aubier M (1998) Inducible expression of the alpha1-acid glycoprotein by rat and human type
II alveolar epithelial cells. J Immunol, 160:4596-4605.
27- Giffroy D, Langendries A, Maurice M, Daniel F, Lardeux B, Courtoy PJ, Vaerman JP
(1998) In vivo stimulation of polymeric Ig receptor transcytosis by circulating polymeric IgA
in rat liver. Int Immunol, 10:347-354.

28- Mejdoubi N, Henriques C, Bui E, Durand G, Lardeux B, Porquet D (1999) Growth
hormone inhibits rat liver alpha-1-acid glycoprotein gene expression in vivo and in vitro.
Hepatology, 29:186-194.
29- Guillonneau F, Drechou A, Pous C, Chevalier S, Lardeux B, Cassio D, Durand G (1999)
Hepatocyte differentiation of WIF-B cells includes a high capacity of interleukin-6-mediated
induction of alpha 1-acid glycoprotein and alpha 2-macroglobulin. Biochim Biophys Acta,
30- Saadane A, Delautier D, Lestriez V, Feldmann G, Lardeux B, Bleiberg-Daniel F (1999)
Down-regulation of liver RNA breakdown by turpentine administration in the starved rat:
autophagy and relevant factors. Inflamm Res, 48:210-217.
31- Rahmani M, Nadori F, Durand-Schneider AM, Lardeux B, Bernuau D (1999) Hepatocyte
growth factor activates the AP-1 complex: a comparison between normal and transformed rat
hepatocytes. J Hepatol, 30:916-925.
32- Saadane A, Delautier D, Leboucher J, Kharbajou M, Feldmann G, Lardeux B, Bleiberg-
Daniel F (1999) Stimulation of liver RNA and protein breakdown in endotoxemic rats: role of
glucocorticoids. Shock,11:429-435.
33- Paugam-Burtz C, Molliex S, Lardeux B, Rolland C, Aubier M, Desmonts JM, Crestani B
(2000) Differential effects of halothane and thiopental on surfactant protein C messenger
RNA in vivo and in vitro in rats. Anesthesiology, 93:805-810
34- Peron P, Rahmani M, Zagar Y, Durand-Schneider AM, Lardeux B, Bernuau D (2001)
Potentiation of Smad transactivation by Jun proteins during a combined treatment with EGF
and TGF-{beta} in rat hepatocytes role of PI3-kinase-induced AP-1 activation. J Biol Chem,
276: 10524-10531.
35- Rahmani M, Peron P, Weitzman J, Bakiri L, Lardeux B, Bernuau D.(2001) Functional
cooperation between JunD and NF-kappaB in rat hepatocytes. Oncogene, 20:5132-42.
36- Goiot H, Attoub S, Kermorgant S, Laigneau JP, Lardeux B, Lehy T, Lewin MJ, Bado
A.(2001) Antral mucosa expresses functional leptin receptors coupled to STAT-3 signaling,
which is involved in the control of gastric secretions in the rat. Gastroenterology, 121:1417-27.
37- Lamboley C, Bringuier AF, Camus E, Lardeux B, Groyer A, Feldmann G. (2002)
Overexpression of the mouse Fas gene in human Hep3B hepatoma cells overcomes their
resistance to Fas-mediated apoptosis. J Hepatol, 36:385-94.
38- Liu P, Kimmoun E, Legrand A, Sauvanet A, Degott C, Lardeux B, Bernuau D. (2002)
Activation of NF-kappaB, AP-1 and STAT transcription factors is a frequent and early event
in human hepatocellular carcinomas. J Hepatol, 37:63-71.
39- Buteau-Lozano H, Ancelin M, Lardeux B, Milanini J, Perrot-Applanat M. (2002)
Transcriptional Regulation of Vascular Endothelial Growth Factor by Estradiol and
Tamoxifen in Breast Cancer Cells: A Complex Interplay between Estrogen Receptors alpha
and beta. Cancer Res, 62: 4977-84
40- Moreau R, Barriere E, Tazi KA, Lardeux B, Dargere D, Urbanowicz W, Poirel O,
Chauvelot-Moachon L, Guimont MC, Bernuau D, Lebrec D.(2002)
Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats
with biliary cirrhosis. Hepatology, 36:1070-8.
41- Hisaka T, Lardeux B, Lamireau T, Wuestefeld T, Lalor PF, Neaud V, Maurel P,
Desmouliere A, Kisiel W, Trautwein C, Rosenbaum J. (2004)
Expression of tissue factor pathway inhibitor-2 in murine and human liver regulation during
inflammation. Thromb Haemost., 91:569-75
42- Legrand A, Vadrot N, Lardeux B, Bringuier AF, Guillot R, Feldmann G. (2004)
Study of the effects of interferon α on several human hepatoma cell lines: analysis of the
signalling pathway of the cytokine and of its effects on apoptosis and cell proliferation. Liver
43- Ansquer Y, Legrand A, Bringuier AF, Vadrot N, Lardeux B, Mandelbrot L, Feldmann G.
(2005) Progesterone induces BRCA1 mRNA decrease, cell cycle alterations and apoptosis in
the MCF7 breast cancer cell line. Anticancer Res., 25: 243-8.
44- Segaud F, Lardeux B, Alexandre-Gouabau MC, Bleiberg-Daniel F, Nakib S, Cynober L,
Moinard C. (2005) Pretreatment of starved rats with ornithine alpha-ketoglutarate: effects on
hepatic mRNA levels and plasma concentrations of three liver-secreted proteins. Nutrition,

45- Neunlist M, Aubert P, Bonnaud S, Van Landeghem L, Coron E, Wedel T, Naveilhan P,
Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP. (2006) Enteric glia inhibits intestinal
epithelial cell proliferation partly through a TGF-β1-dependent pathway. Am J Physiol
Gastrointest Liver Physiol.
, [Epub ahead of print]
46- Costet P, Cariou B, Lambert G, Lalanne F, Lardeux B, Jarnoux AL, Grefhorst A, Staels
B, Krempf M. (2006) Hepatic PCSK9 expression is regulated by nutritional status via insulin
and sterol regulatory element-binding protein 1c. J Biol Chem. 281: 6211-8.
47- Daniel F, Legrand A, Pessayre D, Borrega-Pires F, Mbida L, Lardeux B, Degott C, van
Nhieu JT, Bernuau D. (2007) Beclin 1 mRNA strongly correlates with Bcl-XLmRNA
expression in human hepatocellular carcinoma. Cancer Invest. 25:226-31.
48- Lebouvier T, Scales TM, Hanger DP, Geahlen RL, Lardeux B, Reynolds CH, Anderton
BH, Derkinderen P. (2008) The microtubule-associated protein tau is phosphorylated by Syk.
Biochim Biophys Acta. 1783:188-92.



di Aldo e Flavia Angotti Loc. Largnano 21, 06025 Nocera Umbra-PG- tel/fax 074281740 -cell.3396800311- E-mail: Vivaio inserito in una Azienda Agricola biologica,situata fra meravigliose,incontaminate colline umbre Coltiviamo le nostre piante senza forzature,curandole con propoli e macerati di erbe spontanee e con concimi Sperimentiamo l'uso di Rimedi Flor

El embarazo

La depresión es la pérdida de interés o placer en casi todas las actividades junto a un sentimiento de tristeza durante la mayor parte del día. Los síntomas más comunes son fatiga o falta de energía, miedo infundado, querer estar solo, enojarse fácilmente, sentimientos de culpa, autoestima baja, dificultad para pensar o concentrarse, dolores generalizados, abatimiento psicofísico, d

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