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PUBLICATIONS
Epidémiologie Moléculaire du Cancer
IRCAD-EITS • 1, place de l’Hôpital • Hôpitaux Universitaires • 67091 Strasbourg Cedex • Tél. +33 3 88 11 90 00 • Fax +33 3 88 11 91 99 E-mail : info@ircad.fr – SIRET 391 854 791 00012 – Code APE 731Z – N° d’id. intracom. FR 45 391 854 791 00012 PUBLICATIONS
1. Epidémiologie Moléculaire du Cancer 1. Burnouf D., Olieric V., Wagner J., Fujii S., Reinbolt J., Fuchs R.P.P., Dumas P. Structural and Biochemical Analysis of
Sliding Clamp/Ligand Interactions Suggest a Competition between Replicative and Translesion DNA Polymerases. J Mol
2. Le Chatelier E., Becherel O.J., d'Alencon E., Canceill D., Ehrlich S.D., Fuchs R.P.P., Janniere L. Involvement of DnaE,
the Second Replicative DNA Polymerase from Bacillus Subtilis, in DNA Mutagenesis. J Biol Chem. 2004;279:1757-67.
3. Pages V., Fuchs R.P.P. Uncoupling of Leading and Lagging-Strand DNA Replication during Lesion Bypass in Vivo.
4. Sommer S., Becherel O.J., Coste G., Bailone A., Fuchs R.P.P. Altered Translesion Synthesis in E. Coli Pol V Mutants
Selected for Increased Recombination Inhibition. DNA Repair 2003;2:1361-9.
5. Pages V., Koffel-Schwartz N., Fuchs R.P.P. RecX, a New SOS Gene that is Co-Transcribed with the RecA Gene in
Escherichia Coli. DNA Repair 2003;2:273-84.
6. Burnouf D., Delincee H., Hartwig A., Marchioni E., Miesch M., Raul F., Werner D. Etude toxicologique transfrontalière
destinée à évaluer le risque encouru lors de la consommation d'aliments gras ionisés. Rapport final Interreg II 2002Projet
7. Broughton B.C., Cordonnier A., Kleijer W.J., Jaspers N.G.J., Fawcett H., Raams A., Garritsen V.H., Stary A., Avril M.F., Boudsocq F., Masutani C., Hanaoka F., Fuchs R.P.P., Sarasin A., Lehmann A.R. Molecular analysis of mutations in DNA
polymerase êta in xeroderma pigmentosumvariant patients. Proc Natl Acad Sci 2002;99:815-820.
8. Horvatovich P., Raul F., Miesch M., Burnouf D., Delincee H., Hartwig A., Werner D., Marchioni E. Detection of
2-alkylcyclobutanones, markers for irradiated foods, in adipose tissues of animals fed with these substances. J Food Prot
9. Raul F., Gosse F., Delincee H., Hartwig A., Marchioni E., Miesch M., Werner D., Burnouf D. Food-borne radiolytic
compounds (2-alkycyclobutanones) may promote experimental colon carcinogenesis. Nutr Cancer 2002;44:189-91.
10. Kurtz J.E., Exinger F., Erbs P., Jund R. Current genetics. The URH1 Uridine ribohydrolase of Saccharomyces cerevisia
11. Delagoutte E., Fuchs R.P.P., Bertrand-Burggraf E. The isomerization of the UvrB-DNA preincision complex couples the
UrvB and UvrC activities. J Mol Biol 2002 Jun 28 2002;320(1):73-84.
12. Duvauchelle J.B., Blanco L., Fuchs R.P.P., Cordonnier A.C. Human DNA polymerase mu (Pol mu) exhibits an unusual
replication slippage ability at AAF lesion. Nucleic Acids Res 2002 May 1 2002;30(9):2061-7.
13. Villani G., Tanguy Le Cac N., Wasungu L., Burnouf D., Fuchs R.P.P., Boehmer P.E. Effect of manganese on in vitro
replication of damaged DNA catalyzed by the herpes simplex virus type-1 DNA polymerase. Nucleic Acids Res 2002;30:
14. Miturski R., Bogusiewicz M., Ciotta C., Bignami M., Gogacz M., Burnouf D. Mismatch repair genes and microsatellite
instability as molecular markets for gynecological cancer detection. Exp Biol Med (Maywood). 2002 Sep 2002;227(8):
15. Bresso A., Fuchs R.P.P. Lesion Bypass in Yeast Cells: Pol Eta Participates in a Multi-DNA Polymerase Process. EMBO J
16. Carnesecchi S., Langley K., Exinger F., Raul F. Geraniol, a component of plants essential oils, sensitive human colonic
cancer cells to 5-fluoroucacil treatment. IARC Sci Publ 2002;156:407-9.
17. Becherel O.J., Fuchs R.P.P., Wagner J. Pivotal Role of the Beta-Clamp in Translesion DNA Synthesis and Mutagenesis
in E. Coli Cells. DNA Repair 2002;1:703-8.
18. Wagner J., Etienne H., Janel-Bintz R., Fuchs R.P.P. Genetics of mutagenesis in E. coli : Various combinations of
translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversity. DNA Repair 2002;1:159-167.
19. Lenne-Samuel N., Wagner J., Etienne H., Fuchs R.P.P. The processivity factor controls DNA polymerase IV traffic
during spontaneous mutagenesis and translesion synthesis in vivo. EBMO 2002Reports 3 (n°1):
20. Miesch M., Horvatovich P., Burnouf D., Delincee H., Hartwig A., Raul F., Werner D., Marchioni E. Efficient reaction
pathway for the synthesis of saturated and mono-unsaturated 2-alkylcyclobutanones. Radiat Phys Chem (accepted) 2002
21. Becherel O.J., Fuchs R.P.P. Mechanism of DNA polymerase II-mediated frameshift mutagenesis. Proc Natl Acad Sci
22. Ohmori H., Friedberg E.C., Fuchs R.P.P., Goodman M.F., Hanaoka F., Hinkle D., Kunkel T.A., Lawrence C.W., Livneh Z., Nohmi T., Prakash L., Prakash S., Todo T., Walker G.C., Wang Z., Woodgate R. The Y-family of DNA polymerases.
23. Fuchs R.P.P., Koffel-Schwartz N., Pelet S., Janet-Bintz R., Napolitano R., Becherel O., Broschard T.H., Burnouf D., Wagner J. DNA polymerases II and V mediate respectively mutagenic (-2 frameshift) and error-free bypass of a single N-2
acetylaminofluorene adduct. Biochemical Society Transactions 2001;29:191-195.
24. Agnez-Lima L.F., Napolitano R.L., Fuchs R.P.P., Di Mascio P., Muotri A.R., Menck C.F.M. DNA repair and sequence
context affect 1O2-induced mutagenesis in bacteria. Nucl Acids Res 2001;29:2899-2903.
25. Carnesecchi S., Langley K., Exinger F., Gossé F., Raul F. Geraniol, a component of plants essential oils, sensitives
human colon cancer cells to chemotherapeutic agents. Nafas-Science 2001;25:29.
PUBLICATIONS
1. Epidémiologie Moléculaire du Cancer 26. Burnouf D., Muturski R., Nagao M., Nakagama H., Nothisen M., Wagner J., Fuchs R.P.P. Early detection of
2-animo-1-methyl-6-phenylimidazo (4,5b) pyrimidine (PhIP)-induced mutations within the Apc gene of rat colon.
Carcinogenesis 2001;22:329-335.
27. Erbs P., Regulier E., Kintz J., Leroy J., Poitevin F., Exinger E., Jund R., Mehtali M. In vivo cancer gene therapy by
adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene.
Cancer Res 2000;60:3813-3822.
28. Burnouf D., Miturski R., Nagao M., Nakagama H., Nothisen M., Wagner J., Fuchs R.P.P. Molecular approach in cancer
epidemiology : Early detection of carcinogen-induced mutation in a whole genome. Intern J Mol Med 2000;5:15-20.
29. Miturski R., Burnouf D., Nothisen M., Bogusiewicz M., Jakowicki J.A. Molecular biology and clinical implication of the
adenomatous polyposis coli (APC) gene. Cell Mol Biol Letters 2000;5:3-18.
30. Hoffmann G.R., Janel-Bintz R., Fuchs R.P.P. Induction of -2 framshift mutations by 2-nitrofluorene,
N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in
permeability and acetyltransferase activity
. Mutation Res 2000;493:127-137.
31. Burnouf D., Fuchs R.P.P. The early detection of frameshift mutations induced by a food-borne carcinogen in rats : A new
tool for molecular epidemiology. Mutation Res 2000;462:281-291.
32. Lenne-Samuel N.H., Janel-Bintz R., Kolbanovsky A., Geacintov N.E., Fuchs R.P.P. The processing of a Benzo(a)pyrene
adduct into a frameshift or a base substitution mutation requires a different set of genes in Escherichia coli. Molecular
Microbiology 2000;38:299-307.
33. Schumacher S., Pinet I., Bichara M. Modulation of transcription reveals a new mechanism of triplet repeat instability in
Escherichia coli. J Mol Biol 2000;307:39-49.
34. Baynton K., Fuchs R.P.P. Lesions in DANN : Hurdles for polymerases ?. TIBS 2000;25:74-79.
35. Napolitano R., Janel-Bintz R., Wagner J., Fuchs R.P.P. All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol
V) are involved in induced mutagenesis. The EMBO Journal 2000;19:6529-6225.
36. Wagner J., Nohmi T. E. Coli DNA polymerase IV mutator activity : Genetic requirements and mutational specificity. J
Bacteriol 2000;182:4587-4595.
37. Bichara M., Pinet I., Schumacher S., Fuchs R.P.P. Mechanisms of dinucleotide repeats instability in E. coli. Genetics
38. Wagner J., Fujii S., Cruz P., Nohmi T., Fuchs R.P.P. The clamp targets DNA Pol IV to DNA and strongly increases its
processivity. EMBO Reports 2000;1:484-488.
39. Agnes-Lima L.F., Dimascio P., Napolitano R.L., Fuchs R.P.P., Menck C.F.M. Mutation spectrum induced by singlet
oxygen in E. coli deficient in exonuclease III. Photochem. Photobiol 1999;70:505-511.
40. Wagner J., Gruz P., Kim S.R., Yamada M., Matsui K., Fuchs R.P.P., Nohmi T. The dinB Gene Encodes a Novel E. coli
DNA Polymerase, DNA Pol IV, Involved in Mutagenesis. Molecular cell 1999;4:281-286.
41. Kurtz J.E., Exinger F., Jund R. New insights in the pyrimidine salvage pathway of S.Cerevisiae: requirements of six genes
for cytidine metabolism. Curr. Genet. 1999;36:130-136.
42. Baynton K., Bresson-Roy A., Fuchs R.P.P. Distinct roles of REv1p and Rev7p during translesion synthesis in
Saccharomyces cerevisiae. Mol. Microbiol. 1999;34:124-133.
43. Becherel O., Fuchs R.P.P. SOS Mutagenesis results from up-regulation of translesion synthesis. J. Mol. Biol. 1999;294:
44. Broschard T.H., Koffel-Schwartz N., Fuchs R.P.P. Sequence-dependent modulation of frameshift mutagenesis at
NarI-derived mutation hot spots. J. Mol. Biol 1999;288:191-199.
45. Burnouf D.Y., Miturski R., Fuchs R.P.P. Sequence context modulation of translesion synthesis at a single
N-2-acetylaminofluorene adduct located within a mutation hot spot. Chem. Res. Toxicol. 1999;12:144-150.
46. Cordonnier A., Fuchs R.P.P. Replication of damaged DNA: molecular defect in Xeroderma pigmentosum variant cells.
Mutation Res. (mini-review) 435 1999111-119.
47. Fuchs R.P.P., Napolitano R.L. Proofreading inactivation obviates the need for SOS induction in frameshift mutagenesis.
Proc. Natl. Acad. Sci. USA 1998;95:3114-19.
48. Burnouf D.Y., Fuchs R.P.P. A single N-2-acetylaminofluorene adduct alters the footprint of the T7 (exo-) DNA polymerase
bound to a model primer/ template junction. Mut. Res 1998;407:35-45.
49. Schumacher S., Fuchs R.P.P., Bichara M. Expansion of CTG repeats from human disease genes is dependent upon
replication mechanisms in E. coli : the effect of Long Patch Mismatch Repair revisited. J. Mol Biol 1998;279:1101-10.
50. Broschard T.H., Lebrun-Garcia A., Fuchs R.P.P. Mutagenic specificity of the food mutagen 2-amino-3-methylimidazo[4,
5-f]quinoline in Escherichia coli using the yeast URA3 gene as a target. Carcinogenesis 1998;19:305-10.
51. Baynton K., Bresson-Roy A., Fuchs R.P.P. Analysis of damage tolerance pathways in Saccharomyces cerevisiae : a
requirement for Rev3 DNA polymerase in translesion synthesis. Mol. Cellular Biology 1998;18:960-966.
52. Napolitano R.L., Lambert I.B., Fuchs R.P.P. SOS factors involved in translesion synthesis. Proc. Natl. Acad. Sci. USA
PUBLICATIONS
1. Epidémiologie Moléculaire du Cancer 53. Delagoutte E., Bertrand-Burggraf E., Dunand J., Fuchs R.P.P. Sequence-dependent modulation of nucleotide excision
repair : the efficiency of the incision reaction is inversely correlated with the stability of the pre-incision UvrB-DNA
complex
. J. Mol. Biol. 1997;266:703-710.
54. Wagner J., Kamiya H., Fuchs R.P.P. Leading versus lagging strand mutagenesis induced by 7,
8-dihydro-8-oxo-2'-deoxyguanosine in Escherichia coli. J. Mol. Biol 1997;265:302-309.
55. Maenhaut-Michel G., Janel-Bintz R., Samuel N., Fuchs R.P.P. Adducts formed by the food mutagen IQ induce
frameshift mutation hot spots through an SOS-independent pathway. Mol. Gen. Genetics 1997;253:634-41.
56. Schumacher S., Fuchs R.P.P., Bichara M. Two distinct models account for short and long deletions within repeats. E.
coli. J. Bact 1997;179:6512-17.
57. Wagner J., Fuchs R.P.P. Frameshift mutagenesis induced in E. coli after in vitro treatment of double stranded DNA with
methylene blue plus white light : evidences for the involvement of lesion(s) other than 8-oxo-7,
8-dihydro-2'-deoxyguanosine
. Chem. Res. Toxicol. 1997;10:568-574.
58. Hoffmann G., Fuchs R.P.P. Mechanisms of Frameshift Mutagenesis : Insight from Aromatic Amines. Chem. Res. in
59. Napolitano R.L., Fuchs R.P.P. New strategy for the construction of single stranded plasmids with single mutagenic
lesions. Chem. Res. in Toxicology 1997;10:667-71.
60. Hoffman J.S., Pillaire M.J., Lesca C., Burnouf D., Fuchs R.P.P. Fork like DNA templates support bypass replication of
lesions that block DNA synthesis on single stranded templates. Proc. Nal. Acad. Sci. USA 1996;93:13766-769.
61. Koffel-Schwartz N., Coin F., Veauté X., Fuchs R.P.P. Cellular Strategies for Accomodating Replication-hindering
Adducts in DNA : Control by the SOS response in E. coli. Proc Natl Acad Sci USA 1996;93:805-10.
62. Hoffmann G.R., Deschenes S.M., Manyin T., Fuchs R.P.P. Mutagenecity of acridines in a reversion assay based on
tetracycline resistance in plasmid pBR322 in E. coli.. Mutation Res. 1996;351:33-43.
63. Donahue B.A., Fuchs R.P.P., Reines D., Hanawalt P.C. Effects of AF and AAF DNA adducts on transcriptional
elongation by RNA Polymerase II. J. Biol. Chem. 1996;271:588-594.
64. Delagoutte E., Bertrand-Burggraf E., Lambert I.B., Fuchs R.P.P. Binding and incision activities of UvrABC exinuclease
on slipped DNA intermediates that generate frameshift mutations. J. Mol. Biol. 1996;257:970-976.
65. Milhe C., Fuchs R.P.P., Lefevre J.F. NMR data show that the carcinogen N-2-AAF stabilises an intermediate of -2
frameshift mutagenesis in a region of high mutation frequency. Eur. J. Biochem 1996;235:120-127.
66. Burnouf D., Nothisen M., Wagner J., Fuchs R.P.P. Point chauds de mutation: des cibles moléculaires pour la détection
de mutations ponctuelles dans le génome humain. Echos du Pancréas 1996;13:58-64.
67. Mihle C., Mohn G., Fuchs R.P.P., Lefevre J.F. Nuclear magnetic resonance evidences of the high flexibility induced by
the fixation of the carcinogen N-2-acetylamiofluorene in a mutation hot spot. Biological Structure and Dynamics 1996
68. Thomas D.C., Veayte X., Fuchs R.P.P. Frequency and fidelity of translesion synthesis of site specific
N-2-acetylaminofluorene adducts during DNA replication in a human cell extract. J.Biol.Chem. 1995;270:21226-21233.
69. Koffel-Schwartz N., Fuchs R.P.P. Sequence determinants for -2 frameshift mutagenesis at NarI-derived hot spots. J.Mol.
70. Belguise-Valladier P., Fuchs R.P.P. N-2-aminofluorene and N-2-acetylaminofluorene adducts: the local sequence context
of an adduct and its chemical structure determine its replication properties. J.Mol.Biol. 1995;249:903-913.
71. Bichara M., Schumacher S., Fuchs R.P.P. Genetic instability within monotonous runs of CpG sequences in E.coli:
processing of Z-DNA structure or slippage mechanism?. Genetics 1995;140:897-907.
72. Thomas D.C., Veaute X., Kunkel T.A., Fuchs R.P.P. Mutagenic replication in human cell extracts of DNA containing site
-specific N-2-acetylaminofluorene. P.N.A.S. USA 1994;91:7752-7756.
73. Belguise-Valladier P., Maki H., Sekiguchi M., Fuchs R.P.P. Effect of single DNA lesions on in vitro replication with DNA
polymerase III holoenzyme: comparison with other polymerases. J.Mol.Biol. 1994;236:15-164.
74. Mihle C., Dhalluin C., Fuchs R.P.P. NMR evidence of the stabilization by the carcinogen N-2-acetylaminofluorene of a
frameshift mutagenesis intermediate. Nucl. Acids Res. 1994;22:4646-4652.
75. Garcia A., Lambert I., Fuchs R.P.P. Dna adduct induced stabilization of slipped frameshift intermediates within repetitive
sequences: implication for mutagenesis. P.N.A.S. USA 1993;90:5989-5993.
76. Napolitano L., Lambert I., Fuchs R.P.P. DNA sequence determinants of carcinogen induced frameshift mutagenesis.
Biochemistry 1993;33:1311-1315.

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Microsoft word - head flicking.doc

Head-Flicking/Shaking Now this is a difficult one. Something, the most likely candidate being a neuro-toxin, causes damage to the trigeminal nerve. This is a major facial nerve which goes from behind the eye down the face and branches out to the nostrils and mouth areas. Once it is damaged, increased blood supply, such as on exercise, triggers ‘electrical’ sensations down the nerve,

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2012 Originalarbeiten Schwarzl, M; Huber, S; Maechler, H; Steendijk, P; Seiler, S; Truschnig-Wilders, M; Nestelberger, T; Pieske, BM; Post, H, 2012 Left ventricular diastolic dysfunction during acute myocardial infarction: Effect of mild hypothermia. Resuscitation. 2012; 83(12):1503-1510 Prüller, F; Raggam, RB; Posch, V; Almer, G; Truschnig-Wilders, M; Horejsi, R; Möller, R; Weghuber, D;

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