SUMMER 2003 NEWSLETTER OF THE MASSA o CHUSETTS CHAPTER AMERICAN A uCADEMY OF PEDIATRICS PRESIDENT’S MESSAGE Birth Defects Forms to Fill Out Pediatric Council There have been many coding and pro- probably flag a practice for a chart audit.
health plans in Massachusetts. The fol-lowing is a brief summary of some of the
Membership Committee
As of September 1, 2003, BCBS will accept
the modifier –25 with a preventive care
visit, reimbursing the E&M code at 50%
the seven-year limit on Candidate Fellows
tation for the complaint is required. Also,
as of September 1, 2003, BCBS will accept
AAP educational activities, etc. The dues
for the Candidate Fellows reach full dues
99050 code for visits after 5 p.m. is still
plan for secure e-mail consultations with
gram will be the “incentive grants” to
local Clerkship Directors and sponsormedical student activities. Please let me
number has been decreased 15%. Patients covered by the SCHIP program
list of drugs that require prior authori-
took the American Board of Pediatrics(ABP — an organization entirely sepa-
zation. If there are medications you feel
to task on the issue of proctored recerti-
fication exams. This method of recertifi-
wharrison@mcaap.org.
children, for instance; 2) We are reporting
series of telephone consultation codes.
September, so district officers can pres-
recertification issue. Get your questions
David Chung, M.D. Chapter Administrator
In addition to the print copy, there will
In the last issue of the Forum, we prom-
insurance plan formularies. By using this
www.mcaap.org. If there is sufficient inter- Forum Editor
est, we may also send this tool to you via
Chapter President
Boston (617) 414-5202; Fax: (617) 414-4541
first four pages list five insurance plans
Vice-President
to these pages for tier information on par-
Worcester (508) 752-4511; Fax: (508) 797-4729
each medication and provide formu-lations and standard dosages. Treasurer
Brockton (508) 894-0618; Fax: (508) 894-0618
Secretary
Arlington (781) 643-7155; Fax: (781) 643-0540
Legal Counsel
examination room for easy reference.
plans that participated for their gracious
Kirkpatrick & Lockhart, Boston (617) 951-9143
assistance. Without their help, the MCAAP
MCAAP formulary guide — its ease of use,
District 1
could not have provided this tool for your
Holyoke (413) 536-2393; Fax: (413) 536-1087
use. If you would like to see other major
chaggerty@mcaap.org. District 2 District 3 Reminder from LDAM
Uxbridge (508) 278-5573; Fax: (508) 278-7142
The Learning Disabilities Association of Massachusetts (LDAM) would like to remind
you that you should have received materials on learning disabilities in the month of
District 4
June. If you have any questions, or would like more information, please contact Teresa
Newton (617) 243-6000; Fax: (617) 256-1565
Citro at (781) 891-5009. You can also visit the LDAM website at www.ldam.org. District 5
Chelmsford (978) 256-4363; Fax: (978) 256-1565
MCAAP COMMITTEES & ADMINISTRATIVE APPOINTMENTS AAP Breastfeeding Emergency Pediatric Services International Child Health Nominating Committee District 6 Coordinators Environmental Hazards Legislation Nutrition
Marblehead (781) 631-7800; Fax: (781) 631-4319
Bylaws Committee Fetus & Newborn Pediatric Council District 7 Massachusetts CATCH Co-Coordinators Finance Committee Healthy Families Pediatric Practice
Boston (617) 638-8000; Fax: (617) 414-3679
Forum Editor Membership PROS Network District 8 Child Abuse & Coordinators Family Violence Foster Care Mental Health Task Force Committee on Immunization Initiative School Health District 9 Adolescence MMS Delegate/ Substance Abuse
Brockton (508) 894-0400; Fax: (508) 894-0618
Continuing Medical House of Delegates Infectious Disease Education Technology District 10 MMS Interspecialty Injury Prevention Developmental Disabilities Committee Representatives & Poison Control
Cohasset (781) 383-6800; Fax: (781) 383-6504
2 The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.F O R U M J O B L I S T I N G S LOOKING FOR POSITION: By Stephanie Schauer Since the licensure of the varicella vaccine
in 1995, the number of cases of varicella
in Massachusetts has significantly decreased.
To gain a better understanding of the epi-
demiology of varicella in the post-vaccine
Prevention expect all states to have indi-
This individual reporting will allow bet-
direction and, by early 2004, will initiate
★ A current draft of the one-sided form
detect vaccine failures. In addition, break-
boards of health, and schools all play an
Looking to Hire or Be Hired?
unusual cases or situations involving vari-
Job listings are a free service provided by The Forum to
cella. For more information, or to make a
MCAAP members and residents completing their training.
Nonmembers may submit ads for a fee.
983-6800 or toll-free at (888) 658-2850.
If you are looking to fill a position MCAAP members: Free Nonmembers: $250 Please submit the following information: MCAAP Committee Updates
function in this age group. It is recognized
- Position Title and Description (25-word limit)
that the use of this tool will take addi-
- Availability (e.g., starting July 2003)- Contact Name
- Address, Telephone Number, E-mail Address
health services to those identified will be
If you are looking for a job MCAAP members and residents: FreeNonmembers: $50
screening test does not justify additional
Please submit the following information:the Greater the Chance the Rest of the
reimbursement for your services at a pre-
ventive visit. A positive screening test,
however, could justify additional charges if
coordinating care. This can be billed using
Please send text information via e-mail to dchung@mcaap.org.
Checks may be mailed to the MCAAP office, c/o Cathleen Hag-
accept it. Alternatively, you can schedule
gerty, Executive Director, P.O. Box 9132, Waltham, MA 02454-9132. All submissions must be received by September 15, 2003,
the patient for a return visit to separately
to be included in the next issue of The Forum. All submissions are
AAP.org address is issued to her/him.
address the mental health dysfunction.
subject to review for appropriateness. For further information,
please contact the editor at dchung@mcaap.org
the June issue of AAP News so be sure to
ment in lieu of the usual code for preven-
tive services, this will decrease your rate
of well-visit compliance when analyzedusing CPT codes. Children’s Mental Health Task Force (CMHTF)
setting up a pilot program for pediatric/
Congratulations to the following new
psychiatrists or counselors for children
4 to 16 at preventive health visits. This
wharrison@mcaap.org. You may also con- http://psc.partners.org.The PSC tool is in the
sensitive and specific tool to identify dys-
Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 3
Pneumococcal Conjugate Vaccine Shortage Is Over!
Pneumococcal conjugate vaccine (PCV7) Prioritization of Groups for Catch-Up
Since providers may not be able to recall
all children simultaneously due to logisti-
cal or vaccine supply issues, groups to be
recalled should be prioritized in the fol-
Vaccine Ordering
During the vaccine shortage, providers in
1) Any infants <12 months of age with
<3 doses or high-risk* children of any
normal monthly vaccine orders by at least
Background
patterns for PCV7 by increasing their next
issued an advisory alerting providers that
a “moderate” shortage of PCV7 existed in
their practice per the guidelines above. We
2) Children <24 months of age with <4
anticipate vaccine orders will need to be
1) defer the fourth dose in children < 24
few months until catch-up is complete. As
always, providers are encouraged to order
months of age until adequate vaccine sup-
plies were available. In Massachusetts, the
affect the infant schedule, except possibly
References
immunization of all children with medical
www.cdc.gov/mmwr/PDF/wk/mm5219.pdf Disease Reporting
administration of catch-up doses of pneu-
also requested to maintain lists of children
It is very important that we identify any
mococcal conjugate vaccine. AAP News
whose doses were deferred for recall when
additional cases due to the vaccine short-
www.aap.org/member/pcv0503.htm
demiology of Streptococcus pneumoniae
* High-risk groups include children with sickle-cell disease,
and its serotypes following PCV7 introduc-
asplenia, HIV infection, chronic illness (including cardiac dis-
tion. We urge providers to report all cases
ease, pulmonary disease, and diabetes), CSF fluid leak,
cochlear implant, or other immunocompromising conditions
Minors’ Access Cards Available in Massachusetts
This important new resource was devel- lescents in Massachusetts.
committed to ensuring that all people have
specifically addressing contraceptive care
and the American Civil Liberties Union of
options counseling, abortion services, sex-
calling Crystal Sanford at (646) 366-1890,
nated pamphlet is small enough to fit into
ext. 11, or by e-mailing crystal@prch.org.
Health is a national, physician-led, not-
rounds and visits with patients. The card
for-profit organization whose mission is to
www.prch.org.
ing the provision of health services to ado-
more active and visible role in support of
4 The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.(consider OTC cromolyn [Nasalcrom] and nasal saline washes [e.g., Neti pots])(consider OTC Naphcon A, Opticon A, VAcne, topical Acne, oral Antibacterial, oral (cephalosporins 1st generation) Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 5 (consider rubbing alcohol/vinegar for mild cases)Antibacterial, oral (cephalosporins 2nd generation) Antibacterial, oral (cephalosporins 3rd generation) Antibacterial, oral (macrolides) Antibacterial, oral (penicillins) Antibacterial, eye Antibacterial, otic Antidepressants 6 The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.consider OTC diphenhydramine [Benadryl](consider OTC fungostatic clotrimazole [Lotrimin] or fungocidal terbinafine [Lamisil])(consider OTC cimetidine, famotidine, ranitidine [TAntifungal, oral Antifungal, topical Antihistamine (non/low-sedating) Antihistamine (sedating — Antiviral Asthma therapy (bronchodilators, immediate relief) Asthma therapy (controller medications) Gastrointestinal Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 7 (always consider using generics rather than branded steroids)(always consider using generics rather than branded steroids)Gastrointestinal OCPs, monophasic OCPs, triphasic OCPs, progestin only OCPs, other Steroids, oral Steroids, topical, medium potency Steroids, topical, high potency The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.
10 mg/kg on day 1, 5 mg/kg days 2 to 5 for OM,
12 mg/kg/day x 5 days for strep pharyngitis
7.5 mg/kg/dose bid x 7 days — consider
alternative to suspension due to poor flavor
10-15 mg/kg/dose tid — higher rate of GI upset
(cephalosporins 1st generation) Antibacterial, oral Antibacterial, oral (cephalosporins 2nd generation) Antibacterial, oral (cephalosporins 3rd generation) Antibacterial, oral (macrolides)
cefadroxil (Duricef) 125/250/500 per 5 susp
cephalexin (Keflex) 125/250 per 5 susp or
cefaclor (Ceclor) 125/187/250/375/500 per
cefprozil (Cefzil) 125/250 per 5 susp or
cefuroxime (Ceftin) 125/250 per 5 susp or
loracarbef (Lorabid) 100/200 per 5 susp or
clarithromycin (Biaxin) 125/250 per 5 susp
erythromycin 200/400 per 5 susp (EES) or
MCAAP Formulary Guide: Drug Formulations and Dosing
50–100 mg po bid — less affected by dairy
0.5 mg/kg qday for 4 doses then 1.2 mg/kg qday
Acne, topical Acne, oral Note: Please consult your own dosing reference and consider drug interactions and contraindications. Doses by weight may not in
benzoyl peroxide 5/10% cream, gel, or lotion
benzoyl peroxide 5%/clinda (Benzaclin) gel
tretinoin (Retin-A) 0.025/0.05/0.1% cream
doxycycline 50/100 mg caps or 100 mg tabs
methylphenidate (Ritalin) 5/10/20 mg tabs
atomoxetine (Strattera) 10/18/25/40/60 mg
Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 9
10 mg/kg on day 1, then 5 mg/kg per day for
oral/esophageal candidiasis or 150 mg po x1 for
200 mg bid x 1 week, repeat qmonth (2 months
for fingernails, 3 to 4 months for toenails)
500 mg qday x 1 week, repeat qmonth (2 months
2.5 mg ages 2 to 5, 5-10 mg ages 6 and over
30 mg bid for ages 6 to 12, 60 mg bid or 180 mg
4 mg tid, max 32 mg per day (adult dosing)
400 mg tid x 7 to 10 days for 1st genital herpes,
x 5 days for recurrent or 400 bid for suppression
250 mg tid x 7 to 10 days for 1st genital herpes,
125 bid x 5 days for recurrent or 250 bid for
1000 mg po bid x 10 days for 1st genital herpes,
500 bid x 5 days for recurrent or 500-1000 qd for
Antifungal, oral Antihistamine (non/low-sedating) Antihistamine Antiviral (herpes treatment/prophylaxis for adults)
fluconazole (Diflucan) 10/40 per 5 susp or
itraconazole (Sporanox) 10 per 5 liquid or
Antifungal, topical
ciclopirox (Loprox) 1% cream (fungocidal)
ketoconazole (Nizoral) 2% cream (fungostatic)
cyproheptadine (Periactin) 2 per 5 syrup or
hydroxyzine (Atarax) 10 per 5 syrup, 25 per
MCAAP Formulary Guide: Drug Formulations and Dosing,
1-2 gtts q2 hours while awake x 2 days, then 1-2 gtts q4
1-2 gtts q2 hours while awake x 2 days, then 1-2 gtts q4
Start 25 mg qhs, increase by 25 mg in bid dosing
Start 150 mg qam; after one week, increase
Antibacterial, oral (penicillins) Antibacterial, eye Antibacterial, otic Antidepressants (dosing for adult patients)
fluoxetine (Prozac) 20 per 5 solution or
The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.Steroids, oral Steroids, topical (c = cream, l = lotion, o = ointment)
MCAAP Formulary Guide: Drug Formulations and Dosing,
10 mg/kg/dose q6 hours — Adults: 800 mg
Asthma therapy (bronchodilators, immediate relief) Asthma therapy (controller medications) Gastrointestinal
albuterol MDI or 0.5% conc soln or 0.083%
levalbuterol (Xopenex) 0.31/0.63/1.25 mg
fluticasone (Flovent) 44/110/220 mcg inhalers
montelukast (Singulair) 4/5 mg chewable or
Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 11
DEP Resumes, Expands Air Quality Forecasting
Reva Levin
high concentrations, they can cause seri-
On May 1, with the arrival of warmer
season,” the Massachusetts Department of
fine particles appear as haze, dust, or soot.
Airborne particles and droplets also tend
daily air quality forecasting for ozone and
year-round daily forecasts for fine particles
distances. When they eventually settle to
the surface, they can soil or damage prop-
through Friday, with the Friday reportincluding air quality predictions for the
Difference Between Particles and Ozone
or particles are elevated and expected to
ment visits, and hospital admissions.
forecast for the last several years, are simi-
general public by updating the forecast on
Other Sources of
its toll-free Air Quality Hotline (800) 882-
1497 and its website at www.mass.gov/dep,
2002 issue of The Forum). Each of them
Information
as well as by notifying the news media. What Particles Are and Where They
populations, and fossil fuel combustion is
Come From
“Particles” or “particulate matter” are
two pollutants is that particles can be a
solid particles and liquid droplets in the
problem at any time of year, unlike ozone,
air we all breathe. Particles are a combina-
www.epa.gov/region01/oms/index.html.
tion of fine solids (such as dirt, soil dust,
therefore tends to be seasonal in nature.
pollens, molds, ashes, and soot) and liquid
For this reason, the DEP issues forecasts
droplets that vary greatly in shape, size,
available at www.epa.gov/ttn/oarpg/ naaqsfin/pmhealth.html.
with a number of harmful health effects. Air Quality Monitoring
quality with a network of monitors across
the state since the 1960s. The primary goal
group when particle levels are high. In a
quality standards designed to protect pub-
polluted with particles, children’s lungs
particles in 1999 and currently maintains
air as efficiently as children’s lungs in
samples on filters that are analyzed in a
laboratory with results usually available in
basis, providing hourly measurements.
Currently, predictions of particle concen-
trations are limited to the cities of Boston,
Worcester, and in the near future, Spring-
erly, particularly those with or prone to
field. The DEP plans to expand its particle-
asthma or other existing respiratory ail-
casting in other parts of the state in the
Health Problems Associated With
themselves during periods of high particle
Particle Pollution
quality forecasting, please call Reva Levin
The Forum Submissions for the next issue of The Forum should be sent to dchung@mcaap.org by September 15, 2003.President’s Message
roles to play, both passive and active.
than ever before; 5) Multivariate statisti-
or highly illogical food, toxin, or factor
Do you have patients in your practice
might be harmful. The answer is not “You
after the fourth DTaP? Is it nearing time
idiot, that’s ridiculous”; it’s “We have no
Assessment Centers (CISA), in association
meticulous studies looking specifically at
a wide variety of factors than before. We
of reactions after the fifth DTaP in children
required, to participate in gathering this
reactions after their fourth DTaP. Boston
passed legislation last year that requires
all physicians to report the presence of a
direction of Dr. Colin Marchant in collabo-
Adams, M.D.; Elizabeth Barnett, M.D.; andCatherine Fleming, M.D.
respond differently to, chemical and bio-
Three Reasons This Research Study Is
accessed by visiting www.state.ma.us/dph/ Being Done bhsre/birthdefects/bdefects.htm.
1. To follow children after the fifth dose
it’s a professional and medical one. The
don’t, and certain elders get specific can-
cognitive factors is for all of us to first
accept the likelihood that they exist and
not have reactions after the fifth DTaP.
studies that are required to discover the
insecticides, food additives, and preserva-
that will have real meaning over time. If You Would Like to Refer Patients – John G. (Sean) Palfrey, M.D., FAAP
1. Meet the family at your practice or any
2. Enroll patients, complete study proce-
dures, and arrange and carry outfollow-up visits. The study visits willconsist of a vaccination/blood test visit,
a follow-up visit, and two to three tele-phone calls. We supply the pediatric physician’s office with nebulizers To refer patients, please contact Susan Michalski, R.N., at (617) 414-7423 to be dispensed to patients in need. This program is easy
or by e-mail at spm@bumc.bu.edu for the physician and easy for the patient. Call for details Information is available at our and references. website: www.vaccinesafety.org RELIABLE RESPIRATORY (781) 551-3335 Servicing New England Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 13 Ben Scheindlin, M.D. PROS (Pediatric Research in Office Set- forms on 40 children with injuries. The
practitioner will only be asked to enroll 30
children aged 2 to 11 years coming in for
check-ups. This study is easy to work into
and six months later. This is a very easy
tices in 59 AAP chapters, PROS practition-
study to do in the office — confidentiality
and fall are ideal seasons to do this health
of patient and doctor is assured — and the
addressing important child health topics.
ter with 33 practices and 143 practition-
the Floating Hospital is one of the princi-
Norton of Ware is one of the PROS practi-
actively recruiting practitioners now.
pilot test CARES, and he is presently help-
Child Abuse Recognition and
ing to recruit practices for the study. Evaluation Study (CARES) This descriptive study seeks to understand Safety Check: A Randomized
how pediatricians assess injuries, distin-
Controlled Trial to Prevent Child Violence
manage those injuries in the real world. It
This is the first interventional study in
with linked educational materials, partici-
pating practices will be randomly assigned
suspected child abuse, an issue that con-
to an innovative violence prevention inter-
regular basis. Participating practitioners
an unrelated anticipatory guidance inter-
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My “Critical Incident” as a Third-Year Student
I’ll never forget my encounter with her at explained to her that she was going to die if
the hospital. Mrs. _____ was a 78-year-old
she refused dialysis. Initially I thought that
her decision to make. I knew it all along,
lady with a history of chronic renal failure
she did not understand the procedure, but
but I just didn’t want to let her go. As long
and bipolar disorder admitted to the hospi-
as she’s competent, the choice, of living a
tal for dialysis consideration. Her renal fail-
she called “closure.” I felt absolutely help-
end for up to 4 or 5 days a week or simply
going to die if she was not put on dialysis
telling herself that she’s lived a full life and
through a chronic, not fatal, disease and
unsure of whether I was going to deal more
yet she’s refusing to choose life. I just
ments, was hers. I realized that as physi-
and let them make informed decisions. The
was very close to her because she lived with
ultimate will and choice to live rests with
the patient and the patient only. What we
lunch tray. She greeted me pleasantly, and
could not walk or see very well. My brother
want for the patient is irrelevant, no matter
I introduced myself as a medical student.
her family, and her most recent hobbies.
Mrs. _____, choosing not to receive dialy-
later attended her mother’s funeral. She
sis, was going to die right in front of my
called frequently during that time, lament-
tures were remarkably similar to those of
my grandmother when she was still alive. I
ance from us. We all tried our best to be
this discussion, and out of nowhere, tears
strong for her, to say words of comfort and
ally very close to Mrs. _____. Her bipolar
disorder turned out to be a non-issue.
don’t think I ever appropriately grieved
over my grandmother’s death. Mrs. _____’s
decided to bring up the issue of dialysis
replied, “So I guess I’m like your second
inevitable death probably provided the first
with her. I explained to her that in end-
outlet for my bereavement since my grand-
stage renal failure, dialysis acts as a “filter”
that I was not willing to let her go. She
metabolites from her blood. She looked at
told me, “You’re still young, B_____, you’ll
versations we shared. I did not tell any of
get used to situations like this.” But I did
my colleagues. I thought that it would be
dialysis is.” So I asked her when she would
locked up in a special place inside me for-
like to start and if her family would be will-
ever, but I share it today with all of you.
ing to help her out. She replied, “I’m not
“hardened.” Not because I won’t care any-
getting dialysis.” I was confused for a
This article was submitted by a medical student at Boston University School of Medicine, Class of 2004. IMPORTANT UPDATES FROM REACH 1,200 PEDIATRICIANS VIA THE FORUM Send your e-mail address to chaggerty@mcaap.org for instant notification of issues important to the MCAAP membership.The Forum 15 THE PRESIDENT WANTS YOU
♦ Feeling too busy to dive into MCAAP activities but
NEWSLETTER OF
♦ Join your colleagues to further the goals of your
THE MASSACHUSETTS CHAPTER AMERICAN ACADEMY OF PEDIATRICS
♦ Build your professional network and extend the care you
offer your patients beyond the examination room.
♦ Please let us know your areas of interest, and we will
Name:_____________________________________________
Address: ___________________________________________
E-mail: ____________________________________________
Interests: __________________________________________
or e-mail Cathleen Haggerty at chaggerty@mcaap.org. President’s Message . . . . . . . . . . . . . . . . . 1 MCAAP Committee Updates . . . . . . . . . . . 1 What Is the MCAAP Doing for You? . . . . . . . . . . . . . . . . . . . . . 2 Varicella Reporting . . . . . . . . . . . . . . . . . . 3 New MCAAP Officers . . . . . . . . . . . . . . . . 3 PCV7 Shortage Over . . . . . . . . . . . . . . . . . 4 Minors’ Access Cards . . . . . . . . . . . . . . . . 4 MCAAP Formulary Guide: Tiers . . . . . . . . 5 MCAAP Formulary Guide: Doses . . . . . . . 9 Air Quality Forecasting . . . . . . . . . . . . . . 12 Reactions to DTaP . . . . . . . . . . . . . . . . . . 13 PROS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Critical Incident . . . . . . . . . . . . . . . . . . . 15 The Forum – VOLUME 4 NO. 3 –
Published by the Massachusetts Chapter of the
American Academy of Pediatrics, designed and
printed by the Massachusetts Medical Society.
Urinary tract infection Definition A urinary tract infection, or UTI, is an infection that can happen anywhere along the urinary tract. The urinary tract includes the: z Bladder z Kidneys z Ureters -- the tubes that take urine from each z Urethra -- the tube that empties urine from Alternative Names Cystitis, a common condition, is usually caused by bacteria entering the ureth
CONTENTS 1. OVERVIEW OF CHYTRIDIOMYCOSIS Catastrophic amphibian population crashes over the last 30 years have been caused by the spread of an emerging fungal disease, chytridiomycosis, caused by the chytrid fungus Batrachochytrium dendrobatidis . The arrival of this pathogen in naïve populations has caused about 122 extinctions worldwide, and is the worst example of a disease impacting