Prof

Michael P. Manns, MD
(* 16 November 1951)
Professor and Chairman
Dept. of Gastroenterology, Hepatology and Endocrinology
Hannover Medical School
Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
Tel: +49 511 532-3306
Fax: +49 511 532-4896


Curriculum vitae
2005-2009 Chairman, Center of Internal Medicine, 1970–1976 Medical School, University of Vienna, 2005 - 2009 Steering committee member of VIRGIL, Founder and President, German Liver Foundation 1977-1981 Resident and Fellow, Department of 1981-1985 Resident and Fellow, Department of bereich 738 “Optimizing conventional and innovative transplants“ 1985-1991 Staff Physician (Oberarzt), Department of Medicine I, University of Mainz; Germany since 2008 Member, Steering Committee of BMBF- 1987-1988 Research Associate – W.M. Keck Autoimmune Disease Centre, Scripps Clinic and Research Foundation, Dept. 2011 Member, External Scientific Council, German Society for Internal Medicine (DGIM) Reactions after Organ Transplantation” Activities in the scientific community,
since 1998 Member, Scientific Advisory Board, honors, awards
1999-2001 Member, Senate of Hannover Medical since 2002 Founder and Chairman of Hep-Net, 1991 hepatitis by autoantibodies against a soluble liver Sir Michael Perrin Lecture, Royal Manns MP, Johnson EF, Griffin KJ, Tan EM,
Sullivan KF. The major antigen of liver-kidney- autoimmune hepatitis is cytochrome P450 db1. J Manns MP, Griffin KJ, Sullivan KF, Johnson EF.
LKM-1autoantibodies recognize a short linear monooxygenase. J Clin Invest 1991;88(4):1370- Naturforscher Leopoldina, National Michel G, Ritter A, Gerken G, Meyer zum
Bueschenfelde KH, Decker R, Manns MP. Anti- GOR and hepatitis C virus in autoimmune liver Philipp T, Durazzo M, Trautwein C, Alex B, Straub P, Lamb G, Johnson EF, Tukey RH, Manns MP.
Recognition of uridine diphosphate glucuronosyl Department of Gastroenterology, transferases by LKM-3 antibodies in chronic Hepatology and Endocrinology is hepatitis D. The Lancet 1994;344:578-581. leading centre for liver research in Desmet V, Gerber MA, Hoofnagle JH, Manns MP,
Europe
Scheuer P. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; Takaki, Wiese M, Maertens G,Depla E, Seifert U, Sheila Sherlock State-of-the-Art Liebetrau A, Miller JL, Manns MP, Rehermann B.
Lecture, British Society of Cellular immune responses persist, humoral responses decline two decades after recovery from a single source outbreak of hepatits C. Nat Gastroenterology and Hepatology Med 2000;6:578-582. (1996 – 2006) Jaeckel E, Cornberg M, Wedemeyer H, Santantonio 2009 Hippokrates Award, Hellenic Society of T, Mayer J, Zankel M, Pastore G, Dietrich M, Trautwein C, Manns MP; German Acute Hepatitis
2010 Resnick Lecturer and Visiting Professor, C Gherapy Group. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med. 2001 Nov Manns MP, McHutchison JG, Gordon SC, Rustgi
2011 Ulrika Broome Lecture, Swedish Society VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK. Peginterferon alfa- 2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. The Lancet. since 2011 Member of the board, German Society Tillmann HL, Heiken H, Knapik-Botor A, Heringlake S, Ockenga J, Wilber JC, Georgen B, Detmer J,
McMorrow M, Stoll M, Schmidt RE, Manns MP.
Research fields
Infection with GB virus C and reduced mortality  inflammatory liver diseases, viral and among HIV-infected patients. N Engl J Med  clinical trials for the treatment of liver diseases, Zender L, Hütker S, Liedke C, Tillmann HL, Zender in particular viral hepatitis, autoimmune liver S, Mundt B, Waltemathe M, Gösling T, Flemming P, Malek NP, Trautwein C, Manns MP, Kühnel F,
Kubicka S. Caspase 8 siRNA prevents acute liver  gastrointestinal oncology, in particular failure in mice. Proc Natl Acad Sci USA cell therapy: hepatocyte transplantation Gelbmann CM, Berg T, Kauffmann W, Kallinowski B, Cornberg M, Jaeckel E, Wedemeyer H, Manns
MP; German HEP-NET Acute HCV Study Group.
Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study. Hepatology 2006, Selected publications
Kossatz U, Vervoorts J, Nickeleit I, Sundberg HA, Manns MP, Meyer zum Bueschenfelde KH. A
Arthur JS, Manns MP, Malek NP. C-terminal
mitochondrial antigen-antibody system in phosphorylation controls the stability and function cholestatic liver disease detected by of p27kip1. EMBO J 25:5159-5170 (2006) radioimmunoassay. Hepatology 1982; 2: 1-7. Manns MP, Gerken G, Kyriatsoulis A, Staritz M, Timmerbeul I, Garrett-Engele CM, Kossatz U, Chen
Meyer zum Büschenfelde KH. Characterization of X, Firpo E, Grünwald V, Kamino K, Wilkens L, a new subgroup of autoimmune chronic active Lehmann U, Buer J, Geffers R, Kubicka S, Manns
MP, Porter PL, Roberts JM, Malek NP. Testing
the importance of p27 degradation by the Lankisch TO, Metzger J, Negm AA, Vosskuhl K, SCFskp2 pathway in murine models of lung and Schiffer E, Siwy J, Weismüller TJ, Schneider AS, colon cancer. Proc Natl Acad Sci USA 103: Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP, Mischak H, Wedemey
Manns MP, Foster GR, Rockstroh JK, Zeuzem S,
Zoulim F, Houghton M. The way forward in HCV treatment—finding the right path. Nat Rev Drug Holdener M, Hintermann E, Bayer M, Rhode A, Wedemeyer H, Yurdaydin C, Dalekos G, Ehrhardt A, Rodrigo E, Hintereder G, Johnson EF, Gonzalez Cakaloglu Y, Degertekin K, Gurel S, Zeuzem S, FJ, Pfeilschifter J, Manns MP, Herrath MG,
Christen U. Braking tolerance to the natural Manns MP. Peginterferon plus Adefovir versus
human liver autoantigen cytochrome P450 2D6 by either drug alone for hepatitis delta. New Engl J virus infection. J Exp Med ;205:1409-22 (2008) Marcellin P, Heathcote EJ, Buti M, Gane E, de Man Poordad F, McCone J Jr, Bacon BR, Bruno S, RA, Krastev Z, Germanidis G, Lee SS, Flisiak R, Manns MP, Sulkowski MS, Jacobson IM, Reddy
Kaita K, Manns M, Kotzev I, Tchernev K,
Buggisch P, Weilert F, Kurdas OO, Shiffman ML, Sniukiene V, Brass CA, Albrecht JK, Bronowicki Trinh H, Washington MK, Sorbel J, Anderson J, JP, SPRINT-2 Investiogators. Boceprevir for Snow-Lampart A, Mondou E, Quinn J, Rousseau untreated chronic HCV genotype 1 infection. New F. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Kang TW, Yevsa T, Woller N, Hoenecke L, Med;359:2442-55 (2008) Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Manns MP Czaja AJ, Gorham JD, Krawitt EL, Mieli-
Rudalska R, Potapova A, Iken M, Vucur M, Weiss Vergani G, Vergani D, Vierling JM. AASLD S, Heikenwalder M, Khan S, Gil J, Bruder D, Practice Guidelines: Diagnosis and Management Manns M, Schirmacher P, Tacke F, Ott M,
of Autoimmune Hepatitis. Hepatology 51: 2193- Luedde T, Longerich T, Kubicka S, Zender L. Senescence surveillance of pre-malignant MCHutchison JG, Manns MP, Muir AJ, Terrault
hepatocytes limits liver cancer development. NA,Jacobson IM, Afdahl NH, Heathcote EJ, Zeuzem S, Reesink HW, Garg J, Bsharat M,
George S, Kauffman RS, Adda N, DiBisceglie AM
combined with Peginterferon and ribavirin in Hepatitis C patients who have not had a sustainedVirologic response to initial interferon- based therapy. N Engl J Med, 362: 1292 – 303 Manns MP, Woynarkowski M, Kreisel W, Lurie Y,
Rust C, Zuckerman E, Bahr MJ, Gunther R, Hultcrantz RW, Spengler U, Lohse AW, Szalay F, Farkkila M, Proels M, Strassburg CP. Azathioprine with budesonide induces remission more effectively than with prednisone in patients with autoimmune hepatitis. Gastroenterology; More than 800 publications, Hirsch Index 88

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