Tuhat.halvi.helsinki.fi

CURRICULUM VITAE
1. BASIC INFORMATION

Full name: Petri Hyytiä

Date and place of birth: 6th of August, 1956, Kuusamo, Finland

Home address:
Present work address:

Citizenship: Finland

Language skills:

Education and degrees:
Docent, Faculty of Biosciences, University of Helsinki Ph.D., Department of Genetics, University of Helsinki (Dissertation: “Alcohol Reinforcement: Genetic Differences and Attenuation by Opioid Antagonists”) M.Sc., Department of Genetics, University of Oulu
Previous professional appointments:
Visiting scientist, Research Program of Molecular Neurology, University of Helsinki Senior Scientist, Department of Alcohol, Drugs and Addiction, National Institute for Health 1996 - 2008 Senior Scientist, Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland Visiting Scientist, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA (October 1 – December 31, 2007) Post-doctoral fellow with George F. Koob, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA Staff Scientist, Alcohol Research Centre, Alko Group Ltd, Helsinki Assistant Head of the Laboratory Animal Department, Alcohol Research Centre, Alko Group 1981-1982 Scholarship student, Laboratoire de Biologie et Génétique Evolutives, Centre National de Research Scientifique, Gif-sur-Yvette, France 2. RESEARCH AND SCIENTIFIC ACTIVITIES

Experience of research:
The Ph.D. thesis work “Alcohol Reinforcement: Genetic Differences and Attenuation by Opioid Antagonists” was supervised by Dr. David Sinclair at
Alcohol Research Centre, Alko Group Ltd, 1993. Research on the opioidergic regulation of alcohol reward and consumption using operant conditioning procedures and pharmacological tools. The project resulted in 5 publications that have been cited 239 times. Professor George F. Koob’s group at the Department of Neuropharmacology
(chair Floyd F. Bloom), The Scripps Research Institute, La Jolla, California, USA,
Research on the GABAergic and dopaminergic neural circuits in modulation of drug reward using in vivo pharmacological and neurochemical tools in various animal models of addiction. Training included extensive education on the theoretical concepts of experimental analysis of addictive behaviour. The Scripps research group constitutes the most important hub of the existing personal scientific networks internationally. The training period resulted in 5 publications that have been cited 695 times.
Current scientific research activity:
The ongoing research project belongs to the field biomedical addiction research. More precisely, the most important ongoing project is part of an international collaboration initiated under the ERA-NET NEURON 2010 call. The project entitled “Dysfunctional neuronal networks in alcoholism: Utilizing translational neuroimaging to identify altered brain connectivity and treatment efficacy predictors” aims at developing MRI protocols for assessment of functional and anatomical connectivity in brain networks both in animal models and alcoholic patients. The project will acquire information on brain connectivity maps specific for alcoholism and on their modification by clinical reference compounds, i.e. acamprosate and naltrexone, in humans and animals. Based on this information we expect to predict better the effects of experimental drugs proposed for treatment of alcoholism in human patients. At Biomedicum Helsinki, the project will be conducted both in the laboratories of the Institute of Biomedicine (Pharmacology), the Experimental MRI Laboratory (head Turgut Tatlisumak), and the university laboratory animal facilities. External funding acquired from the Academy of Finland for the 3-year (2011-2013) project: Personnel €
Consumables €
Equipment €
Travel €
Other direct costs (services) €
Overheads €
Total €
Recruitment of personal is in progress. The students participating in the project in 2011 include: Leena Penna (BSc), Mateusz Dudek (MSc). Registration of PhD student status has not yet been completed. The international participants of the project include: Wolfgang Sommer, MD PhD (Dept. of Psychopharmacology, Central Institute for Mental Health, Karl Mann, MD PhD (Dept. of Addiction Medicine, Central Institute for Mental Health, Mannheim, Serdar Dursun, MD PhD (Dept. of Psychiatry, University of Alberta, Edmonton, Canada) Santiago Canals, PhD (Instituto de Neurociencias, University Miguel Hernández, Alicante, Spain)
Publication record:
The list of publications includes a total of 92 items, including 74 peer-reviewed research articles, 10 articles published in edited volumes and conference proceedings, and 8 book chapters. Citation statistics based on ISI Web of Science (October 2010): Sum of the times cited: 2.315, H-index: 26

According to the classification of Web of Science, the publications represent the following main subject
areas (partly overlapping percentages): substance abuse (54%), pharmacology & pharmacy (38%), Selection of important papers pertinent for the present project: Bäckström P, Etelälahti T, Hyytiä P (2011). Attenuation of reinforcing and psychostimulant effects
of amphetamine by aripiprazole. Addict Biol 16:55-63. IF = 4.728 Björk K, Rimondini R, Hansson AC, Teräsmaa A, Hyytiä P, Heilig M, Sommer WH (2008) Modulation
of voluntary ethanol consumption by beta-arrestin 2. FASEB J 22:2552-60. IF = 6.401 Bäckström P, Hyytiä P (2007) Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the
nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) 192: 571-80. IF = 4.103 Bäckström P, Hyytiä P (2006) Ionotropic and metabotropic glutamate receptor antagonism
attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31: 778-86. IF = 6.993 Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R (2004) mGluR5 antagonist MPEP reduces
ethanol-seeking and relapse behavior. Neuropsychopharmacology 29:921-8. IF = 6.993 Lintunen M, Hyytiä P, Sallmen T, Karlstedt K, Tuomisto L, Leurs R, Kiianmaa K, Korpi ER, Panula P
(2001). Increased brain histamine in an alcohol-preferring rat line and modulation of ethanol consumption by H(3) receptor mechanisms. FASEB J 15:1074-6. IF = 6.401 Weiss F, Parsons LH, Schulteis G, Hyytiä P, Lorang MT, Bloom FE, Koob GF (1996) Ethanol self-
administration restores withdrawal-associated deficiencies in accumbal dopamine and 5- hydroxytryptamine release in dependent rats. J Neurosci 16:3474-3485. IF = 7.178
Scientific expert positions:
2006- : Receiving editor of Addiction Biology Reviewer for several journals in the field of neuroscience, pharmacology and addiction research, including: Addiction Biology, Alcohol, Alcohol and Alcoholism, Alcoholism Clinical and Experimental Research, Brain and Behavioural Functions, Brain Research, Brain Research Bulletin, Drug and Alcohol Dependence, European Journal of Neuroscience, European Journal of Pharmaceutical Sciences, European Neuropsychopharmacology, FASEB Journal, Genes, Brain and Behavior, Journal of Neurochemistry, Naunyn-Schmiedeberg’s Archives of Pharmacology, Neuropharmacology, Neuropsychopharmacology, Neuroscience and Biobehavioral Reviews, Pharmacology, Biochemistry and Behavior, Progress in Neuro-Psychopharmacology & Biological Psychiatry, Psychopharmacology Distinguished International Scientist Collaboration Program Award 2007, awarded by the National Institute Participation in previous major international projects:
EU-funded (5. framework) project “Identification and validation of molecular targets for pharmacological treatment of alcohol dependence” (QLG3-CT-2002-01048 ,TARGALC) 2002-2005, project coordinator Markus Heilig (Karolinska Institute, Sweden). Role as a partner: Recruitment of personal, supervision and coordination of work, budget planning and follow-up.
Scientific collaboration:
On-going scientific collaboration with Finnish investigators: Esa Korpi (Institute of Biomedicine, University of Helsinki): Behavioral models of drug dependence. Pertti Panula (Institute of Biomedicine, University of Helsinki): Role of the central histamine system in regulation of alcohol-related behaviors. Jari Tiihonen, James Calloway, Marko Lehtonen (Department of Forensic Psychiatry, Department of Pharmaceutical Chemistry, University of Kuopio): Alterations in brain endocannabinoid levels Iiris Hovatta (Research Program of Molecular Neurology, University of Helsinki): Role of - aminolevulinate dehydratase (ALAD) in anxiety-like behavior. Erika Roman (University of Uppsala, Sweden): Assessment of risk-taking behavior, impulsivity and anxiety in rat lines selected for differential alcohol preference. Bo Söderpalm (University of Gothenburg, Sweden): Involvement of glycine receptors in regulation Elizabeth Jerlhag, Jörgen Engel (University of Gothenburg, Sweden): Epigenetic analyses of the pro- ghrelin and GHS-R1A genes in rat brain. Wolfgang Sommer (Central Institute of Mental, Health University of Heidelberg, Germany): Gene expression profiling and neuroimaging in animal models of alcoholism. Giancarlo Colombo (CNR Institute of Neuroscience, Italy): Effects of allosteric GABAA modulators on William McBride (Indiana University School of Medicine, USA): Region-specific gene expression profiling in rat lines selected for differential alcohol preference.

3. TEACHING AND SUPERVISION

Experience of undergraduate and graduate teaching and supervision
I have participated in supervision of both undergraduate and graduate theses in various roles (see the full list below). I have reviewed Ph.D. theses both at the universities of Helsinki, Kuopio and Tampere, and acted as an opponent at the Universities of Helsinki and Tartu. Antti Turhala, Faculty of Pharmacy, University of Helsinki, 1999 Pia Bäckström, Faculty of Biosciences, University of Helsinki, 2000 Tiina Etelälahti, Faculty of Biosciences, University of Helsinki, 2006 Päivi Kivinen, Faculty of Biosciences, University of Helsinki, 2007 Veera Holopainen, Faculty of Biosciences, University of Helsinki, 2009 Sami Ojanen, Faculty of Biosciences, University of Helsinki, 2007
Supervised Ph.D. theses:
Pia Bäckström, Faculty of Biosciences, University of Helsinki, 2002-2006 Hanna Malinen, Faculty of Biosciences, University of Helsinki, 2004- (suspended due to illness)
Reviewed Ph.D. theses:
Jyrki Rintala, Faculty of Medicine, University of Tampere, 2002 Jarno Riikonen, Faculty of Medicine, University of Tampere, 2004 Markus Storvik, Faculty of Pharmacy, University of Kuopio, 2004 Anne Tammimäki, Faculty of Biosciences, University of Helsinki, 2008 Anne Tamminiemi, Faculty of Pharmacy, University of Helsinki, 2007 Tanja Kivinummi, Faculty of Pharmacy, University of Helsinki, 2008 Kristiina Kaste, Faculty of Pharmacy, University of Helsinki, 2008 Heidi Kemppainen, Faculty of Biosciences, University of Helsinki, 2008 Tanja Kivinummi, Faculty of Pharmacy, University of Helsinki, 2009 Silva Sütt, Department of Physiology, University of Tartu, Estonia, 2010 Lectures for undergraduate and graduate students
I have actively participated in organizing courses on neuropharmacology for graduate students of various graduate schools at the Institute of Biomedicine. For several years, I have lectured on the neurobiology of alcoholism during the alcohol theme day at the faculty of medicine. Lectures on the neurobiology of addiction have been given also for psychiatrists and psychologists. More general lectures on addiction medicine have recently been initiated at the Helsinki Open University. Regular lectures on the neurobiology and genetics of alcoholism and drug addiction (lectured both in English ”Alkoholiriippuvuuden hermostollinen ja perinnöllinen tausta”. Vuosittainen Ruoansulatus ja ravitsemus opintojakso/Päihdepäivä (Lääketieteellinen tiedekunta, Helsingin yliopisto), 1996 ”Opioidiriippuvuuden hermostollinen perusta” (Opioidiriippuvaisia hoitavien koulutus, Järvenpään sosiaalisairaala), 2002”Animal models of drug craving and relapse” (Graduate school in pharmaceutical research, Universities of Kuopio and Helsinki), 2006 “Neuronal Plasticity in Drug Addiction”. NeuPhar 2008-kurssi: Neuropharmacology and brain gene expression (Institute of Biomedicine, University of Helsinki, with the participation of Finnish Graduate School in Neurosciences, Drug Discovery Graduate School, Helsinki “Role of the endocannabinoid system in alcohol and drug dependence”. (Department of Biosciences, University of Kuopio), 2008 ”Päihdehäiriöiden etiologia ja patogeneesi”. Psykiatrian erikoistumiskoulutus, runkoseminaari (Psykiatrian klinikka, Helsingin yliopisto), 2009 - 2011 ”Päihderiippuvuuden neurobiologinen ja geneettinen tausta”, EU1A04x Päihteet, aivot ja terveys –seminaari (Psykologian laitos, Helsingin yliopisto), 2009 “Animal models of addiction”. NeuPhar2010: Neuropharmacology and behavioural animal models (Institute of Biomedicine, University of Helsinki, with the participation of Finnish Graduate School in Neurosciences, Drug Discovery Graduate School, Helsinki Biomedical ”Päihteiden käytön fyysiset ja psyykkiset vaikutukset”. Päihdelääketieteen perusteet, Avoin yliopisto (Lääketieteellinen tiedekunta, Helsingin yliopisto), 2009-2011

Source: https://tuhat.halvi.helsinki.fi/portal/files/14993744/CV_Hyyti_eng_Apr11.pdf