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Human Reproduction, Vol.24, No.12 pp. 3196 – 3204, 2009 Advanced Access publication on October 3, 2009 ORIGINAL ARTICLE Reproductive epidemiology Physical activity and fertility in women:the North-Trøndelag Health Study S.L. Gudmundsdottir1, W.D. Flanders2, and L.B. Augestad1,3 1Human Movement Science Programme, Faculty of Social Sciences and Technology Management, Norwegian University of Science andTechnology (NTNU), NO-7491 Trondheim, Norway 2Departments of Epidemiology and Biostatistics, Emory University, Atlanta,GA 30345, USA 3Correspondence address. Tel: þ47 7359-1780; Fax: þ47 7359-1770; E-mail: liv.berit.augestad@svt.ntnu.no background: Changes in the state of energy balance owing to changes in physical activity may affect the reproductive system. Weevaluated the association between physical activity (PA) and fertility and parity in healthy women.
methods: A population-based health survey (HUNT 1) was conducted during 1984 – 1986 in Nord-Trøndelag county, Norway, withfollow-up from 1995 to 1997 (HUNT 2). The study included 3887 women, ,45 years old in HUNT 2. PA was assessed by baseline ques- tionnaire, and fertility and parity by questionnaire at follow-up. Data focused on overall occurrence of infertility in the population (withoutbiological confirmation).
results: Increased frequency, duration and intensity of PA were associated with increased subfertility, and frequency of PA was associ-ated with voluntary childlessness (P , 0.01). After adjusting for age, parity, smoking, and marital status, women who were active on mostdays were 3.2 times more likely to have fertility problems than inactive women. Exercising to exhaustion was associated with 2.3 times theodds of fertility problems versus low intensity. Women with highest intensity of PA at baseline had the lowest frequency of continuing nulli-parity and highest frequency of having three or more children during follow-up (P , 0.05). Sensitivity analysis including body mass index asconfounder did not alter the results. No associations were found between lower activity levels and fertility or parity.
conclusion: Increased risk of infertility was only found for the small group of women reporting the highest levels of intensity and fre-quency of PA. Awareness of the possible risks of infertility should be highlighted among non-athletic women who exercise vigorously.
Key words: epidemiology / exercise / infertility / physical activity / women Kravdal, 2008). It is suggested that one-third of the incidences ofcouple infertility can be related to male reproductive problems Infertility is defined as the inability of a couple to conceive within 1 year of trying to become pregnant (Kumar et al., 2007). Recent Reproductive dysfunction is reported to have a higher prevalence in estimates of the prevalence of infertility range from 3.5 to 16.7% in athletes than non-athletes (Russell et al., 1984; Otis et al., 1997), with more developed nations and from 6.9 to 9.3% in less developed clinical consequences that may include infertility (Warren et al., nations (Boivin et al., 2007). In Norway, the lifetime infertility preva- 2001). Less is known about the effects of physical activity (PA) on lence has been estimated to be 6.6% (Rostad et al., 2006).
female fertility in the general population, in contrast to the relatively A variety of lifestyle factors, such as smoking (Hughes and Brennan well-known beneficial effects of regular PA for numerous undesirable 1996; Augood et al., 1998; Hull et al., 2000), psychological stress health outcomes, including the prevention of premature death (Hjollund et al., 1999), caffeine (Wilcox et al., 1988) and alcohol con- (Bouchard and Blair 1999; Warburton et al., 2006). Only a few sumption (Gill, 2000; Eggert et al., 2004) and extremely low or high studies have focused on the general population. In a cohort study, the body mass index (BMI) (Rich-Edwards et al., 2002; Hassan and Nurses’ Health Study II, more hours of vigorous exercise were associ- Killick 2004; Norman et al., 2004) have been proposed as causes of ated with reduced risk of ovulatory infertility (Rich-Edwards et al., 2002; infertility. Consequences of infertility may include psychosocial pro- Chavarro et al., 2007) while Morris et al. (2006) found that women who blems (Greil, 1997; Boivin, 2003), higher risks of breast and ovarian had enrolled on a fertility treatment programme and reported exercis- cancer (Jensen et al., 2008) and high financial costs for those trying ing 4 h or more per week for 1 – 9 years previously were 40% less likely infertility treatment (Jain and Hornstein 2003). In addition, childless- to have a live birth, almost three times more likely to experience cycle ness has been related to mortality disadvantages (Grundy and cancellation, and twice as likely to have an implantation failure or & The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
For Permissions, please email: journals.permissions@oxfordjournals.org pregnancy loss than women who had reported not exercising. Moremoderate exercise together with weight loss has been found to be posi-tive in fertility treatment in obese women (Clark et al., 1995). The effectof PA on fertility may therefore be positive up to a certain level and havea negative effect above that threshold level of activity. A similar pattern issuggested for bone health: physically active individuals have been foundto have a lower risk of low bone mineral density and fractures, while therisk of stress fractures is increased with high-volume training (Kohrtet al., 2004). This may occur through the direct effects of activity on hor-mones which stimulate bone formation or indirectly via effects on estro-gen and menstrual function, a condition often coupled with negativeenergy availability in an interrelationship known as the female athletetriad (Nattiv et al., 2007).
PA plays an important role in maintaining energy balance and it has been suggested that changes in the status of energy balance due tochanges in PA may affect the reproductive system (Redman, 2006).
In addition, there are some indications that weight loss via PA mayprotect ovarian function by increasing insulin resistance and changingthe hormone profile (Norman et al., 2004).
The purpose of this study is to evaluate the association between PA and fertility status and parity in healthy, premenopausal, Norwegian All residents in the county of Nord-Trøndelag, Norway, men and womenaged 20 years, were invited to participate in the Nord-Trøndelag Health Figure 1 Sequential exclusion of participants in the study of phys- Study in 1984 – 1986 (HUNT 1) and in the follow-up study in 1995 – 1997 ical activity and fertility. *No response to questions needed for Among those eligible for HUNT 1, 77 310 (90.8%) returned a health-related questionnaire and 74 977 (88.1%) participated in thehealth examination. At the examination, participants filled out a secondquestionnaire, including questions regarding PA.
Fertility status and reproductive history were assessed by a self- In HUNT 2, 71.3% of the original cohort from HUNT 1 participated. Par- reported questionnaire in HUNT 2. Questions included inability to con- ticipants were sent a comprehensive health-related questionnaire by mail.
ceive within 1 year of trying (and at what age), parity, age at childbirth(s), Assessments at the screening station included measurements of height and contraceptive use and menstruation and pregnancy status.
weight. At the examination, participants received a more detailed question- We classified women as fertile if they conceived within 1 year of naire evaluating demographics, medication use, diet, reproductive history, attempting to become pregnant and gave birth, and infertile if they did infertility, menstrual history, history of gynaecological surgery and pregnancy.
not conceive within 1 year, regardless of any subsequent pregnancies In total, 24 837 women participated in both surveys. Of those, 5986 (Kumar et al., 2007). Infertile women were further classified as women were ,45 years old at HUNT 2, and therefore considered pre- subfertile if the time to pregnancy exceeded 1 year of trying, and as menopausal. We excluded women who reported serious conditions or involuntarily childless if they reported problems with conceiving within diagnoses known to affect capability for PA or reproductive function at 1 year and there had been no childbirth. Voluntarily childlessness was baseline, as summarized in Fig. 1, leaving 3887 women in our study.
assumed if neither problems with becoming pregnant nor childbirth Weekly frequency, intensity and duration of leisure time PA was assessed using a self-reported questionnaire in HUNT 1 (http://www.
Fertility status and parity for different levels of baseline variables were ntnu.no/eksternwebEN/aboutntnu/facultiesanddepartments/dmf/HUNT/ compared using descriptive and chi-square statistics. We modelled the questionnaires/) (Table I). The questions regarding PA have been vali- probability of fertility problems (subfertility or involuntary childlessness) dated for men with good reliability and test and retest validity (Kurtze using unadjusted and adjusted logistic regression. For infertility, odds et al., 2008). Based on the reported intensity, duration and frequency, ratio (ORs) estimates were obtained by maximum likelihood with associ- an index of PA was calculated: detailed descriptions are presented in pre- ated 95% confidence intervals (CIs). We were concerned there might be viously published papers (Augestad et al., 2004; Augestad et al., 2006).
some link between PA and age and therefore performed subgroup ana- With division at the 33.3th and 66.6th percentiles of the index, leisure lyses for young women, ,30 years of age, because of the higher preva- time PA was categorized into low, moderate and high levels. Occupational PA was assessed by asking the women if they felt physically tired The associations of baseline measurements with parity were examined from occupational work (almost never, seldom, often, almost always).
in women who were nulliparous in HUNT 1. Comparisons were made Age, education, marital status, smoking, and alcohol consumption were using ordinal regression models, adjusting for potential confounders.
reported at baseline. BMI (kg/m2) was computed from measured height In these analyses parity was treated as a three-level variable: nulliparous, one to two children and more than two children.
Table I Baseline characteristics of the healthy Norwegian female study population PA, physical activity. Fertility status based on self-reported problems with conceiving within 1 year and childbirths at follow-up. P-values indicate results of the Pearson’s chi-square test. n (%).
In all of the above analyses, models were run separately for each of the subfertility and voluntary and involuntary childlessness were approxi- PA variables (frequency, intensity, duration and index). Full multivariate mately J-shaped, and subfertility was least common in the normal models were run at first. Variables were subsequently removed from weight group (BMI: 18.5 – 24.9). Based on the univariate analyses, the models if their removal did not affect the coefficient estimates of women classified as fertile were more often married and had less the remaining variables in the model or the overall significance of the than 10 years of education. Voluntarily childless women were more often unmarried, non-smokers, with more than 12 years of education.
Based primarily on a priori considerations, we considered the following Subfertility was least common among married women (Table I).
baseline measurements as potential confounders: age (5-year categories),parity, i.e. when assessing the probability of infertility (nulliparous, not nul- Increased frequency of PA was associated with increased subfertility liparous) (Sternfeld et al., 1999; Miller et al., 2002), smoking (never, and voluntary childlessness. A similar relationship was observed former, current), frequency of alcohol consumption during the 14 days between intensity and longer duration of PA and subfertility but less prior to participation in the study (never, 1 – 4 times, 5 – 10 times, .10 so with voluntary childlessness. In the unadjusted analyses, a high times) marital status (unmarried, married, previously married) and edu- level of PA, according to our calculated index, was associated with increased subfertility and voluntary childlessness. Due to missing Women with an unusually high or low BMI tend to have greater risk of answers however, the PA index could not be calculated for just infertility. Because women with high or low BMI may be either less likely or over 1000 women. Tiredness from occupational activity was not more likely to be physically active, baseline BMI may be considered a found to be associated with fertility status (Table I).
potential confounder of the relationship between PA and fertility.
The observed relationships between PA variables and fertility status However, BMI might also be considered an intermediate variable in that followed the same trend as those reported above, after controlling for PA could affect BMI and, in turn, fertility status. We therefore did notinclude BMI as an independent variable in the primary (a priori) analyses, suspected confounding factors: age, parity, smoking and marital status because its inclusion might have biased the estimated association (Table II). Additional control for education and alcohol consumption between PA and fertility status. However, to assess whether inclusion of did not meaningfully affect the ORs. In particular, women who were BMI affected the estimated association with fertility status, we also con- active on most days of the week were 3.2 times more likely to be ducted additional (sensitivity) analyses that included this variable, treating infertile than inactive women. Exercising to exhaustion was associated it as categorical (World Health Organization categorization of under-, with 2.3 times the odds of infertility compared with lower levels of normal- and overweight, obesity and severe obesity) at baseline. Statistical intensity. For duration, there was decreased risk of infertility in those whose exercise was moderate (16 – 30 and 30 – 60 min) com- The study was approved by the Norwegian Regional Committee for pared with the shortest duration of less than 15 min. Women who, Ethics in Medical Research and the Norwegian Data Inspectorate and according to the index of PA, were highly active had an OR of 1.5 each subject gave written informed consent prior to participation.
for infertility compared women with low or moderate levels of activity.
The alternative analysis, designed to assess the sensitivity of results to alternative models, in which we included BMI as a potential con-founding factor, did not result in notably different parameter esti- Baseline characteristics and their bivariate relations to fertility status at mates, consistent with the small differences in BMI across the follow-up are shown in Table I. The mean baseline age was 27.2 years (range 20 – 35) and mean BMI was 22.7 kg/m2 (range 14.5 – 44.1).
In a subgroup analysis restricted to women up to 30 years of age in Overall, 90.1% of the women were classified as fertile, 5.1% as subfer- whom subfertility was more common (6.3%) than in the older age tile, 0.7% as involuntary childless and 3.9% as voluntary childless.
group (1.5%), we found that these younger women were more A total of 62.4% of infertile women reported having visited a likely than older women to exercise every day, exercise to exhaustion medical doctor for fertility problems.
or exercise for more than 60 min. Among the young women, subfer- The frequency of subfertility decreased with increased age, as did tility was reported by 23.7% of those exercising to the level of exhaus- voluntary childlessness. The relationships of BMI categories with tion and by 11.1% of those who reported exercising almost every day.
analyses of this group, continued nulliparity at follow-up was associ- Table II Unadjusted and adjusted ORs from logistic ated with greater age and with lower or higher than normal BMI.
regression for fertility problems (subfertility or Parity during follow-up was also related to education. However, it should be noted that at baseline, 93.7% of women with ,10 yearseducation had already given birth (Table I). For women who had not given birth at baseline, we found similar ORs of infertility as for the whole sample but the 95% CIs were larger and included 1 in all Women who reported the highest intensity of PA at baseline had the lowest frequency of continuing nulliparity and highest frequency of having three or more children during follow-up (P , 0.05). In the unadjusted analysis, there was also a tendency towards less continuing nulliparity and higher parity among those women with longer durationsof PA and higher scores on the PA index (Table III).
There was a significant tendency towards higher parity among women with the highest intensity of PA compared with moderate intensity in an ordinal regression analysis, adjusting for age and edu- cation. Women reporting low intensity of activity did not significantly differ from the high intensity group. The model was subsequently run including BMI but no meaningful changes to the parameter estimates were observed. In another subgroup analysis excluding those women who were voluntarily childless in HUNT 2, although the direc- tion of this association was the same, the relationship was no longer Frequency of PA or tiredness from occupational activity was not #Adjusted for age, parity, smoking and marital status.
In this study we examined the association between PA and fertility *Reference category OR, odds ratio; CI, confidence interval.
status and parity in healthy premenopausal Norwegian women. Wefound that women with the highest levels of frequency or intensity In this subgroup there was a u-shaped relationship between duration of PA had increased risk of infertility. We did not, however, see a of exercise and subfertility. Among women who reported ,15 min or trend for increased risk of infertility for the submaximal levels of inten- .60 min duration, the frequency of subfertility was 12.6 and 12.4%, sity or frequency of PA. Moreover, the highest level of our index of respectively, while 3.9% of women exercising for 16 – 30 min and PA, indicating the total load of exercise, was related to increased like- 7.0% of those exercising for 30 – 60 min reported subfertility.
lihood of infertility in adjusted analyses. There was decreased risk of In this subgroup, adjusted logistic analysis showed similar but some- infertility for women reporting moderate duration of activity in our what stronger relationships than in the study group as a whole. The adjusted analyses, compared with women reporting activity duration OR for infertility was 3.5 (CI: 1.3 – 9.0) for women who exercised of less than 15 min. Our estimate of 5.8% prevalence of infertility is almost every day and women who exercised to the level of exhaustion somewhat lower than earlier reports from the same study population had 3.0 (CI: 1.3 – 6.0) times the risk of infertility compared with those in which lifetime infertility prevalence has been estimated to be 6.6% taking it easy. The trend between the calculated index of PA, occu- (Rostad et al., 2006). The women in our sample were younger than in pational activity or other variables did not differ meaningfully from the Rostad et al. (2006) study and some may still experience infertility patterns observed in the analyses that included all age groups.
in their remaining reproductive years.
Women who were nulliparous at baseline were significantly younger Although we showed that high intensity of PA was related to than women who had given birth (24.0 versus 26.5; P , 0.001). They increased risk of infertility, there was also a trend of having three or had higher occurrence of frequent PA, higher intensity and longer dur- more children during the follow-up period among women who ation of activity (P , 0.001 for all). Nulliparous women were less likely reported the highest level of PA intensity at baseline. A possible expla- to feel tired from occupational activity. They had higher education at nation may be that women who did high intensity training at baseline baseline, and were more likely to be non-smokers and unmarried and experienced infertility problems adjusted their activity level to a than women who had given birth (P , 0.001 for all). The two lower intensity level. Alternatively, although if intense PA had a nega- groups did not differ on baseline BMI.
tive effect on the first trial for conception, hormonal changes during For women who were nulliparous at baseline, the mean number of and following pregnancy may have counteracted that negative effect children born between baseline and follow-up investigations was 1.5 in later pregnancies. The likelihood of fertility problems in our study (range 0 – 4). A total of 179 women were still nulliparous at follow-up, was, however, not notably different for nullipara women compared of whom 152 (84.9%) reported voluntary childlessness. In descriptive with those who had already given birth. This may suggest that the Table III Baseline characteristics of women who were nulliparous at baseline (n 5 786) PA, physical activity. Childbirths during follow-up reported in questionnaire. P-values indicate results of the Pearson’s chi-square test. n(%).
possible detrimental effects of high intensity exercise are reversible did not try to identify different causes of infertility with biological and not permanent. Unfortunately, our data did not allow further con- testing but focused on the overall occurrence in the population and this may have biased our results. Green et al. (1986) found that There have only been a few studies regarding the effect of PA on fer- among infertile women who had never conceived, high intensity exer- tility status and parity in the general female population. Our results are cise for more than 60 min/day was associated with even higher risk somewhat comparable to results of a retrospective case – control study of infertility after excluding cases with evidence of tubal dysfunction.
which found a 6.2-fold increased risk of infertility in women who exer- Differences in measurement methods for infertility may contribute to cised vigorously (defined as aerobic activities with estimated energy differences in results, to some extent. Also, not all women who partici- requirements of 6 kcal/min) for at least 60 min per day (Green et al., pated in the baseline survey did so in the follow-up survey. If non- 1986). There are also reports of lutheal phase alterations, which may participation at follow-up was jointly associated with PA and infertility, lead to infertility, among recreational runners with at least 2 h per bias may have resulted. Many women did not answer questions regard- week of exercise and running 32 km/week (De Souza et al., 2003).
ing fertility status and we cannot exclude the possibility that those The recreational runners in the De Souze study had lower BMI and women differed from women who did answer; this could have affected fat mass than sedentary controls and the results were related to short- our results. Our analysis found, however, that women who did not term negative energy balance and hypometabolic state, similar to but answer questions regarding fertility status in the follow-up study had not as extensive as seen in amenorrheaic athletes.
somewhat lower intensity and duration of PA at baseline than women Results from the Nurse’s Health Study indicate reduced risk of ovu- who did answer those questions, although this difference was not stat- latory infertility in women doing vigorous exercise for at least 30 min istically significant. Because data on fertility status were collected retro- daily (Chavarro et al., 2007). An earlier report of the same cohort indi- spectively, recall bias may have occurred. Nevertheless, since fertility cated a 7% relative risk reduction for ovulatory infertility for each status is of high personal interest, precise recollection of its aspects additional hour of vigorous exercise per week (Rich-Edwards et al., may be likely. Other sources of bias may have been spousal infertility 2002). Thus, there is a considerable divergence in study results. The and change of partner, which we could not control for in our data.
mean age in our study group was approximately 5 years lower than PA may affect fertility merely temporary or more permanently in in the women in the Nurse’s Health Study and this may explain the the reproductive life, but our study did not obtain information at difference in results to some extent, as we found younger women the time when women tried to conceive. Although we excluded more likely to report both highest intensity of PA and infertility than women who reported infertility at baseline we cannot be certain whether the level of PA reported at baseline was maintained until PA can improve body composition, glucose homeostasis and insulin sensitivity (Warburton et al., 2006). Exercise-induced weight loss has In epidemiological studies, the intensity of PA can be assessed as been shown to improve metabolic function and hormonal profiles, and absolute or relative intensity. Metabolic equivalent task is frequently often leads to significant increase in fertility (Clark et al., 1995; used to refer to absolute intensity indicating the energy cost of an Norman et al., 2004). In our study, adjustment for BMI did not signifi- activity. PA-related energy expenditure has been associated with mor- cantly alter the increased risk of infertility associated with the highest bidity and mortality (Helmrich et al., 1994; Manini et al., 2006; Mora intensity or frequency of activity. Thus, the effect of PA may largely act et al., 2007). Besides being an important determinant of health, data through a mechanism that does not involve BMI to a significant extent.
on energy expenditure also facilitate study result comparisons and It is possible that in normal weight women, high loads of exercise, interpretation of findings into meaningful units, although misreporting not coupled with increased energy intake, lead to negative energy errors have been observed (Mahabir et al., 2006). Relative intensity balance where the energy requirements of reproductive functions can be described by use of the Borg scale (Borg, 1982) or other cannot be met (Loucks et al., 1998). This may explain our finding of measures of how intense the exercise is perceived by each subject.
increased infertility risk among women doing high intensity training In the current study, information regarding PA was based on a self- reported questionnaire that allowed for subjective interpretation of Our study is population based, not depending on cases seeking help PA variables. It may therefore suffer from misclassification of activity from a clinic, and can be viewed as a cohort study. The prospective by factors such as age, social situations and seasonal variation assessment of the effect of baseline PA on subsequent fertility problems (Vanhees et al., 2005). Including a large number of study subjects hopefully contributes to avoiding selection bias of cases and reporting and classifying subjects into wide categories, e.g. low, moderate, bias of activity levels. However, there were possible limitations. We misclassification (Shephard, 2003). The questions regarding intensity Trøndelag County Council and The Norwegian Institute of Public and duration of PA in the current study have previously been validated in a small sample of women and men over a wide age range (Wisloffet al., 2006). The results indicate a positive association betweenreported intensity and the measures of oxygen uptake during exercise.
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The Submitted on March 13, 2009; resubmitted on August 21, 2009; accepted onSeptember 1, 2009

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