Arginine An Amino Acid for the Heart NPN: 80002697 180 Vegi-Caps AOR04054 • Improves heart health Serving Size: 1 Capsule • Nitric oxide precursor Key Features: Supports Cardiovascular Health Suggested Use: • Protects the heart from high blood sugar levels Take 3 capsules one to three times • Helps in cellular energy production
directed by a qualified health care practitioner. Cautions: A Healthier Heart
L-arginine is an amino acid with many important health benefits, myocardial infarction (heart attack).
especially in the cardiovascular system. Its abilities to block plaque a health care practitioner prior to
formation and blood clots have shown benefits in arterial hypertension,
peripheral vascular disease and angina. Arginine reduces platelet medications, potassium increasing aggregation and blood viscosity and improves blood flow. In non-
acidic and high oxygen conditions, it is a precursor for the synthesis Pregnancy / Nursing: of nitric oxide, a potent blood vessel dilator, which also acts as an Do not take antioxidant. Arginine has also been shown to improve the body’s Source: Main Indications: Support Exercise Capacity Energy and Insulin
Other effects of arginine include releasing growth hormone, glucagon
and insulin, detoxifying amino acids, and synthesizing creatine, which
is needed for cellular energy production. In diabetics, high levels of Cardio Mag 2.0, Co-enzyme Q10,
glucose in the blood can lead to heart disease. Arginine is able to reverse the negative cardiovascular effects of high blood sugar.
Conditionally Essential, Always Beneficial
Arginine is classified as a conditionally essential amino acid, and This information has not been evaluated by the Natural Health Product Directorate of Canada (NHPD). Supplements mentioned
arginine deprivation can lead to decreased growth rate, metabolic are not intended to diagnose, treat, cure, mitigate or prevent any medical condition. The only exceptions are those health
disorders and even death. Deficient or not, studies have shown that claims approved by the NHPD, which are listed on the labels of each product and on the NHPD website for products with Natural
there is nothing conditional about its diverse health benefits. Product Numbers (http://webprod3.hc-sc.gc.ca/lnhpd-bdpsnh/index-eng.jsp).Advanced Innovative Research Orthomolecular Research www.aor.ca & Scientific Integrity
AOR™ 3900 – 12th Street NE, Calgary, AB T2E 8H9
Arginine was originally believed to be a nonessential amino acid that could be sufficiently synthesized in the body. This changed when research showed that arginine deprivation decreased the rate of growth and/or lead to severe metabolic disorders and even death. In the last forty years numerous studies have emphasized the diverse range of arginine’s physiological effects including the release of growth hormone, glucagon and insulin, amino acid detoxification and the synthesis of creatine - an important compound for generating ATP, the “cellular currency” of the cell. Arginine is a physiological precursor of nitric oxide (NO), a potent vasodilator.
Physiological Effects Cardiovascular Disorder
Extensive studies have demonstrated arginine’s antiatherogenic, anti-ischaemic and antithrombic properties. The
eventual consequence of atherogenic events is formation of plaque in the arteries, which leads to compromised
endothelial function which in turn leads to reduced vasodilation. Arginine has been shown to not only prevent further
progression but also to stimulate regression of plaque formation! The initiating event in atherosclerotic plaque formation is monocyte adhesion to the endothelium followed by entry of
these monocytes into blood vessels, transformation into macrophage cells, uptake of lipids and eventually fatty streak/
foam cell formation. Arginine is reported to reduce the adhesion of monocytes to the endothelial cells in coronary
patients and in smokers. NO, produced from arginine, has potent free radical quenching properties and hence acts
as an antioxidant. Numerous experimental and clinical studies have demonstrated the therapeutic potential of high dose arginine for the
prevention and treatment of a broad spectrum of cardiovascular diseases, in preventing endothelial damage and in
restoration of endothelial function. Specifically, it has been shown to benefit arterial hypertension, peripheral vascular
disease, angina and the so called “Syndrome X”. Arginine has been successfully employed for the treatment of mild-
to-moderate but not severe congestive heart failure, with a dose of 12.6g per day. Diabetes
Diabetes mellitus is a metabolic disorder which strongly predisposes an individual to cardiovascular disease.
Hyperglycemia is thought to cause diabetic complication through the formation of reactive oxygen species (ROS),
which cause direct endothelial damage, and advanced glycation end products (AGE’s) which are toxic species that
change the structure and function of physiological proteins. The net result is an increase in retinopathy, nephropathy
and neuropathy. High blood glucose levels also reduce NO availability. Arginine however, can reverse the vascular
effects of high glucose concentration. A small randomized, double blind, placebo-controlled study, demonstrated that
6 grams of arginine improved exercise capacity in angina patients. Arginine reduces platelet aggregation and blood viscosity, improves blood flow and helps repair vascular injury.
Arginine is considered a promising therapeutic agent for the prevention of restenosis and improving the outcome
following heart transplantation and coronary bypass.
A dose of 1.5g daily for 6 months in a clinical trial of interstitial cystitis resulted in a significant decrease in urinary
voiding discomfort and diminished abdominal and vaginal/urethral pain. Urinary frequency was significantly
decreased. Arginine has been used for treating male infertility by improving spermatogenesis. Since arginine is a precursor of
NO, and NO is a potent vasodilator, it is conceivable that arginine would be of benefit in penile erectile dysfunction
much like the mechanism of action of Viagra. Animal studies have reported benefits in acute liver and brain injury.
Advanced Innovative Research Orthomolecular Research www.aor.ca & Scientific Integrity
AOR™ 3900 – 12th Street NE, Calgary, AB T2E 8H9
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B BLECAUTE uma revista de literatura e artes Campina Grande-PB, Ano 2, n. 7 , p. 51 “– QUEM PUSERA O DISCO PARA TOCAR?” NINGUÉM REPAROU: mas no dia em que abandonaram definitivamente a casa, a radiola vermelha tocava o último sucesso de Roberto Carlos.” Durante o trajeto até à pista de asfalto, ela seguia, pensando se alguém se lembraria de desligar a radiola e guardar