Tetracycline (hydrochloride)
according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008 Section 1. Identification of the Substance/Mixture and of the Company/Undertaking 1.1 Product Code:
Product Name:
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride; 1.2 Relevant identified uses of the substance or mixture and uses advised against:
Relevant identified uses: For research use only, not for human or veterinary use.
1.3 Details of the Supplier of the Safety Data Sheet:
Company Name:
Cayman Chemical Company1180 E. Ellsworth Rd.
Ann Arbor, MI 48108 Web site address:
1.4 Emergency telephone number:
Emergency Contact:
2.1 Classification of the Substance or Mixture:
2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:

Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2A
Target Organ Systemic Toxicity (single exposure), Category 3

2.1.2 Classification according to Directive 1999/45/EC:
Xi: Irritant
Risk Phrases: R36/37/38

For full text of R- phrases: see SECTION 15.
2.2 Label Elements:
2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:

GHS Signal Word:
GHS Hazard Phrases:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
GHS Precaution Phrases:
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.
GHS Response Phrases:
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.
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Tetracycline (hydrochloride)
P337+313: If eye irritation persists, get medical advice/attention.
P309+311: Call a POISON CENTER or doctor/physician if exposed or you feel unwell.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
GHS Storage and Disposal Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.
2.2.2 Labeling according to Directive 1999/45/EC:
Adverse Human Health Causes skin irritation.
Effects and Symptoms: Causes serious eye irritation.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
May cause respiratory irritation.
To the best of our knowledge, the toxicological properties have not been thoroughlyinvestigated.
Section 3. Composition/Information on Ingredients Hazardous Components (Chemical Name)/
Risk Phrases/
REACH Registration No.
EC Index No.
GHS Classification
Description of First Aid

In Case of Inhalation:
Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trainedpersonnel. Get immediate medical attention.
In Case of Skin
Immediately wash skin with soap and plenty of water for at least 15 minutes. Remove Contact:
contaminated clothing. Get medical attention if symptoms occur. Wash clothing beforereuse.
In Case of Eye
Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyes Contact:
examined and tested by medical personnel.
In Case of Ingestion:
Wash out mouth with water provided person is conscious. Never give anything by mouthto an unconscious person. Get medical attention. Do NOT induce vomiting unlessdirected to do so by medical personnel.
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Tetracycline (hydrochloride)
Suitable Extinguishing Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.
Use water spray to cool fire-exposed containers.
A solid water stream may be inefficient.
Extinguishing Media:
Flammable Properties No data available.
and Hazards:
Flash Pt:
Explosive Limits:
Autoignition Pt:
Fire Fighting
As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH Instructions:
approved or equivalent), and full protective gear to prevent contact with skin and eyes.
Protective Precautions, Avoid raising and breathing dust, and provide adequate ventilation.
Protective Equipment
As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or and Emergency
respirator, and appropriate personal protection (rubber boots, safety goggles, and heavy Procedures:
Take steps to avoid release into the environment, if safe to do so.
Methods and Material
Contain spill and collect, as appropriate.
For Containment and
Transfer to a chemical waste container for disposal in accordance with local regulations.
Cleaning Up:
Precautions To Be
Avoid breathing dust/fume/gas/mist/vapours/spray.
Taken in Handling:
Avoid prolonged or repeated exposure.
Precautions To Be
Taken in Storing:
Store in accordance with information listed on the product insert.
Section 8. Exposure Controls/Personal Protection 8.1 Exposure Parameters:
Partial Chemical Name
Britain EH40
France VL
Partial Chemical Name
Other Limits
8.2 Exposure Controls:
8.2.1 Engineering Controls
Use process enclosures, local exhaust ventilation, or other engineering controls to (Ventilation etc.):
control airborne levels below recommended exposure limits.
8.2.2 Personal protection equipment:
Eye Protection:
Protective Gloves:
Other Protective
Respiratory Equipment NIOSH approved respirator, as conditions warrant.
(Specify Type):
Work/Hygienic/Mainten Do not take internally.
ance Practices:
Facilities storing or utilizing this material should be equipped with an eyewash and a Multi-region format
Tetracycline (hydrochloride)
safety shower.
Wash thoroughly after handling.
Section 9. Physical and Chemical Properties 9.1 Information on Basic Physical and Chemical Properties
Physical States:
Appearance and Odor:
Melting Point:
Boiling Point:
Flash Pt:
Evaporation Rate:
Explosive Limits:
Vapor Pressure (vs. Air or
Vapor Density (vs. Air = 1):
Specific Gravity (Water = 1): No data.
Solubility in Water:
Solubility Notes:
~3.3 mg/ml in PBS (pH 7.2); ~1 mg/ml in DMSO; ~1.4 mg/ml in DMF; Autoignition Pt:
9.2 Other Information
Percent Volatile:
Molecular Formula & Weight: C22H24N2O8 • HCl 480.9
Stability Note(s):
Stable if stored in accordance with information listed on the product insert.
Conditions To Avoid:
Incompatibility -
Materials To Avoid:
Decomposition Or
Multi-region format
Tetracycline (hydrochloride)
Information on
The toxicological effects of this product have not been thoroughly studied.
Toxicological Effects: Tetracycline (hydrochloride) - Toxicity Data: Oral LD50 (rat): 6443 mg/kg; Intraperitoneal
LD50 (rat): 318 mg/kg; Subcutaneous LD50 (rat): 700 mg/kg; Oral LD50 (mouse): 2759mg/kg; Intraperitoneal LD50 (mouse): 368 mg/kg; Oral TDLO (rat): 2000 mg/kg; OralTDLO (mouse): 600 mg/kg; Oral TDLO (man): 200 mg/kg/7D (intermittent); Chronic Toxicological Tetracycline (hydrochloride) - Investigated as a mutagen, reproductive effector, and
Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presentedhere. See actual entry in RTECS for complete information.
Tetracycline (hydrochloride) RTECS Number: QI9100000 Carcinogenicity:
NTP? No IARC Monographs? No OSHA Regulated? No Toxicity:
Avoid release into the environment.
Runoff from fire control or dilution water may cause pollution.
Waste Disposal
Dispose in accordance with local, state, and federal regulations.
DOT Proper Shipping Name: Not dangerous goods.
DOT Hazard Class:
UN/NA Number:

ADR/RID Shipping Name:
UN Number:
Hazard Class:

ICAO/IATA Shipping Name:
Additional Transport
Transport in accordance with local, state, and federal regulations.
EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists
Hazardous Components (Chemical Name)
S. 302 (EHS)
S. 313 (TRI)
Hazardous Components (Chemical Name)
Other US EPA or State Lists
CAA HAP,ODC: No; CWA NPDES: No; TSCA: Inventory; CA Multi-region format
Tetracycline (hydrochloride)
European Community Hazard Symbol codes:
European Community Risk and Safety Phrases:
Irritating to eyes, respiratory system and skin.
Wear suitable protective clothing, gloves and eye/face protection.
Regulatory Information
This SDS was prepared in accordance with Regulation (EC) No.1272/2008 and Statement:
European Directive 67/548/EEC as amended.
Revision Date:
Additional Information About No data available.
This Product:
Company Policy or
DISCLAIMER: This information is believed to be accurate and represents the best Disclaimer:
information currently available to us. However, we make no warranty of merchantabilityor any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations todetermine the suitability of the information for their particular purposes.
N.A.=Not available, N.P.=Not applicable, N.D.=Not determined, N.E.=Not established,N.R.=Not required Multi-region format

Source: https://www.caymanchem.com/msdss/14328m.pdf


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