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(For additional information see "Budesonide: Drug information" and see "Budesonide: Pediatricdrug information")
U.S. Brand Names Entocort® EC; Pulmicort Flexhaler™; Pulmicort Respules®; Rhinocort® Aqua® Canadian Brand Names Entocort®; Gen-Budesonide AQ; Mylan-Budesonide AQ; Pulmicort®; Rhinocort® Aqua™; Rhinocort® Turbuhaler® Mexican Brand Names Aerosial; Entocort; Miflonide; Numark; Pulmicort; Rhinocort Pharmacologic Category Corticosteroid, Inhalant (Oral); Corticosteroid, Nasal; Corticosteroid, Systemic What key warnings should I know about before taking this medicine?
• When switching from an oral steroid to an inhaled one, there can be problems.
Symptoms such as weakness, feeling tired, dizziness, nausea, vomiting, inability tothink clearly, or low blood sugar may occur. Call healthcare provider right away if youhave any of these symptoms. If you have a serious accident and are injured, havesurgery, or any type of infection, you may need extra doses of oral steroids. Theseextra steroids will help your body deal with these stresses. Carry a warning cardsaying that you may need extra steroids at certain times.
• This medicine does not mix well with many medicines. Serious reactions may occur.
Check all medicines with healthcare provider. Reasons not to take this medicine
• Do not give this medicine to a child younger than 1 year old. • If you have an allergy to budesonide or any other part of this medicine.
• If you are allergic to milk, talk with healthcare provider. • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about
the allergy and how it affected you. This includes telling about rash; hives; itching;shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or anyother symptoms involved.
• If you are having a breathing attack. What is this medicine used for?
• This medicine is used to treat asthma. It may take 2-6 weeks to see the full effect. • This medicine is used to treat Crohn's disease. It may take 2 months to see the full
• This medicine is used to relieve allergy symptoms. • This medicine is used to treat nasal congestion. It may take 2 weeks to see the full
How does it work?
• Budesonide prevents or reduces irritation, inflammation, and swelling. • It blocks the allergic reaction by minimizing or preventing the body's reaction to the
• It decreases the body's harmful response to diseases affecting the immune system. How is it best taken? Oral inhalation: • For inhaling (puffing) only. • Prime inhaler before first use by twisting brown grip as far as it will go in both
• Check inhaler use with healthcare provider at each visit. Read and follow all
instructions provided with inhaler. Using the inhaler the right way is very important.
• Do not use a spacer with the inhaler. • Rinse out mouth after each use. • If you are using an inhaled bronchodilator, wait 10 minutes before using this
Oral capsule: • Take this medicine in the morning if taking once a day. • Take this medicine with or without food. Take with food if it causes an upset
• Swallow capsule whole. Do not chew, break, or crush. Nasal:
• For the nose only. • Shake well before use. • Blow your nose before use. • Check spray use with healthcare provider at each visit. Read and follow all
instructions provided with spray. Using the spray the right way is very important. Nebulizer: • For inhaling as a liquid (solution) through a special machine (nebulizer) into the
• Follow directions given by healthcare provider or read the package insert. • Do not mix other medicines in nebulizer. • Shake well before use. • Rinse out mouth after each use. • Wash face if using a face mask. • If you are using an inhaled bronchodilator, wait 10 minutes before using this
What do I do if I miss a dose? (does not apply to patients in the hospital)
• Take a missed dose as soon as possible. • If it is almost time for the next dose, skip the missed dose and return to your regular
• Do not take a double dose or extra doses. • Do not change dose or stop medicine. Talk with healthcare provider. What are the precautions when taking this medicine?
• If you have been taking this medicine for several weeks, talk with healthcare
provider before stopping. You may want to gradually withdraw this medicine.
• Wear disease medical alert identification. • Talk with healthcare provider before receiving any vaccinations. Use with this
medicine may either increase the risk of serious infection or make the vaccination lesseffective.
• Do not run out of this medicine. • Do not use this medicine to treat an asthma attack. • Do not take antacids within 2 hours of this medicine. • Avoid exposure to chickenpox and measles. • If you have diabetes, talk with healthcare provider. This medicine can increase blood
• If you have glaucoma or cataracts, talk with healthcare provider.
• If you have high blood pressure, talk with healthcare provider. • If you are being treated for any infection, talk with healthcare provider. • If you have kidney disease, talk with healthcare provider. • If you have liver disease, talk with healthcare provider. • If you have osteoporosis, talk with healthcare provider. • If you have seizures, talk with healthcare provider. • If you have stomach ulcers, talk with healthcare provider. • If you have thyroid disease, talk with healthcare provider. • If you have tuberculosis, talk with healthcare provider. • If you have a weakened heart, talk with healthcare provider. • Check medicines with healthcare provider. This medicine may not mix well with other
• Tell dentists, surgeons, and other healthcare providers that you use this medicine. • Avoid grapefruit and grapefruit juice. • Avoid alcohol (includes wine, beer, and liquor). • Tell healthcare provider if you are pregnant or plan on getting pregnant. • Tell healthcare provider if you are breast-feeding. What are some possible side effects of this medicine? Oral inhalation: • Headache. • Nasal congestion. • Mouth sores. To prevent, rinse mouth with water and spit out. • Lung infection. Oral capsule: • Risk of infection. Avoid people with infections, colds, or flu. • Headache. • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard,
sugar-free candy, or chewing sugar-free gum may help.
• Acne. • Mood changes. Nasal: • Headache. • Nasal irritation. Nebulizer: • Lung infection. • Nasal congestion.
• Cough. • Ear infection. • Mouth sores. To prevent, rinse mouth with water and spit out. • Severe allergic reactions can rarely occur. What should I monitor?
• Change in condition being treated. Is it better, worse, or about the same?• Check blood sugar as directed by healthcare provider. • If using for asthma, the number of asthma attacks. • Follow up with healthcare provider. Reasons to call healthcare provider immediately
• If you suspect an overdose, call your local poison control center or emergency
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever;
itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher,
chills, severe sore throat, ear or sinus pain, cough, increased sputum or change incolor, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
• Feeling extremely tired, weak, or irritable; trembling; having a fast heartbeat,
confusion, sweating, or dizziness if you missed a dose or recently stopped thismedicine.
• Difficulty breathing. • Significant weight gain. • Severe nausea or vomiting. • Severe nasal irritation. • Severe mouth irritation. • Severe muscle pain or weakness. • Sudden change in vision. • If exposure to chickenpox has occurred and you have not had chickenpox or been
• Any rash. • No improvement in condition or feeling worse. How should I store this medicine? Oral capsule: • Store at room temperature.
• Protect from heat. • Protect powder from moisture. Do not store in a bathroom or kitchen. Oral inhalation: • Store at room temperature. Throw away after date shown on the inhaler. • Protect from moisture. Do not store in a bathroom or kitchen. Nasal: • Store spray at room temperature with valve up. Throw away any unused portion
• Protect from heat. • Protect from moisture. Do not store in a bathroom or kitchen. Nebulizer: • Store upright at room temperature. Throw away any unused portion after 2 weeks. • Protect from light. General statements
• If you have a life-threatening allergy, wear allergy identification at all times. • Do not share your medicine with others and do not take anyone else's medicine. • Keep all medicine out of the reach of children and pets. • Most medicines can be thrown away in household trash after mixing with coffee
grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements,
vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor,nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to
FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Programat 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-
counter, natural products, or vitamins.
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Biotechnol. Appl. Biochem. (2001) 33 , 65–69 (Printed in Great Britain) Synthesis and analysis of ethylated tetracycline, an antibiotic derivative that inhibits the growth of tetracycline-resistant XL1-Blue bacteria Ronald Bartzatt1, Kelly Koziol, Theresa Benish and Jason Stoddard Chemistry Department , College of Arts and Sciences , University of Nebraska , Omaha , NE 68182
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