CURRICULUM VITAE Name: António Braz da Silva Parreira Qualifications: Diploma in Medicine - Lisbon University School of Medicine - 1972. Haematology Board Certificate - Lisbon University School of Medicine, Santa Maria Hospital - 1979. PhD in Haematology - Lisbon University School of Medicine - 1989. Positions held: Junior Assistant of Pharmacology - 1969-72. Internship in Internal Medicine - 1973-74. Resident in Internal Medicine, Santa Maria Hospital - 1975-76. Resident in Haematology, Henri Mondor Hospital, Creteil, France, supported by a grant from the French Government - 1977. Resident in Clinical Haematology, Santa Maria Hospital, Lisbon 1977-80. Consultant of Clinical Haematology, Santa Maria Hospital, Lisbon - since 1981-90. Research Fellow at the Leukaemia Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, supported by a grant from the Gulbenkian Foundation - 1983-85. Assistant Professor of Immunology, Lisbon University School of Medicine, 1985-1989. Consultant of Clinical Haematology, Portuguese Institute of Cancer, Lisbon, 1990. Associate Professor of Haematology, Lisbon University School of Medicine, 1989-1992. Present Appointment: Head of Department of Clinical Haematology and the Hemato-Oncology Reseach Unit, Instituto Português de Oncologia, Lisbon, since 1992. Professor of Hematology Faculdade Ciencias Medicas, Universidade Nova de Lisboa, since 1996. Member of the following Scientific Societies: Sociedade das Ciências Médicas de Lisboa Sociedade Portuguesa de Hematologia Association Espanola de Hematologia y Hemoterapia The European Society for Medical Oncology The International Society of Hematology American Society of Hematology Selected Publications: Configuration of immunoglobulin and T-cell receptor ß and g genes in acute myeloid leukemia: pitffals in the analysis of 40 cases. Parreira L, Carvalho C, Moura H, Melo A, Santos P, Guimaraes JE, Parreira A. Journal of Clinical Pathology, 45;193-200, 1992. Splenic lymphoma with villous lymphocytes in two sisters. I. Ribeiro, M.M. Costa, B.A. Fernandes, I. Sousa, A. Melo, A. Parreira, L. Sousa Uva. Journal of Clinical Pathology, 45;1111-1113, 1992. Myositis with tretinoin [letter] Miranda N, Oliveira P, Frade MJ, Melo J, Marques MS, Parreira A. Lancet 344: 1096, 1994. Differential expression of cell adhesion molecules in the functional compartments of lymph-nodes and tonsils. R.P. Leite, M. Carmo-Fonseca, J. Cabeçadas, A. Parreira, L. Parreira. Journal of Clinical Pathology: Molecular 48:M93-M100, 1995. Natural Killer cell numbers and activity in mobilized peripheral blood stem cell grafts: Conditions for in vitro expansion. Silva MR, Parreira A, Ascensao JL. Experimental Hematology 23:1676-1681, 1995. HTLV tax gene expression in patients with lymphoproliferative disorders. Cardoso EA, Miranda N, Gameiro P, Frade MJ, Figueiredo M, Parreira A. Journal of Clinical Pathology 49:11 938J. 1996.
Large-Volume leukaphereses may be more efficient than standard-volume leukaphereses for collection of peripheral blood progenitor cells. Passos-Coelho JL, Machado MA, Lucio P, Leal-da-Costa F, da Silva MG, Parreira A. Journal of Hematotherapy 6:465-474, 1997 Expression of adhesion molecules on chronic B-cell lymphoproliferative disorders. Lucio P, Faria T, Pinto A, Silva MRG, Junior E, Marques da Costa R, Parreira A. Haematologica 83: 104-111, 1998. Flow cytometric analysis of normal B-cell differentiation: a frame of reference for the detection of minimal residual disease in precursor B-ALL patients. Lucio P, Parreira A, van den Beemd MWM, van Lochem EG, van Wering ER, Baars E, Porwit-MacDonald A, Bjorklund E, Gaipa G, Biondi A, Orfao A, van Dongen JJM, San Miguel JF. Leukemia, 13; 419-27, 1999. The Nuclear Topography of ABL, BCR, PML and RARa Genes: Evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. H. Neves, C. Ramos, M Gomes da Silva, A. Parreira, L. Parreira. Blood, 4;1197-1207, 1999. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in Acute Leukemia for detection of Minimal Residual Disease – Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in Acute Leukemia. JJM van Dongen, EA MacIntyre, E Delabesse, JA Gabert, G Canniza, G Saglio, E Gottardi, A Rambaldi, P Dotti, F Griesinger, A Parreira, P Gameiro, M Gonzalez Diaz, M Malec, AW Langerak, JF San Miguel, A Biondi. Leukemia 13:1901-1928 1999 CD123hi Dendritic Cell Lymphoma: An unusual case of Non-Hodgkin Lymphoma (NHL). P Lúcio, A Parreira, A Orfao. Annals Int Med 131(7):549-550, 1999. Flow cytometric characterization of CD7+ cell subsets in normal bone marrow as a basis for the diagnosis and follow up of T cell acute lymphoblastic leukemia ((T-ALL). A Porwit-MacDonald, E Bjorklund, P Lúcio, EG van Lochem, J Mazur, A Parreira, MWM van den Beemd, ER van Wering, E Baars, G Gaipa, A Biondi, J Ciudad, JJM van Dongen, JF San Miguel, A Orfao. Leukemia 14:816-825, 2000 High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H. Dearden CE, Matutes E, Cazin B, Tjonnfjord GE, Parreira A, Nomdedeu B, Leoni P, Clark FJ, Radia D, Rassam SM, Roques T, Ketterer N, Brito-Babapulle V, Dyer MJ, Catovsky D. Blood Sep 15;98(6):1721-6, 2001 BIOMED-I concerted action report: flow cytometric immunophenotyping of precursor B-ALL with standardized triple-stainings. BIOMED-1 Concerted Action Investigation of Minimal Residual Disease in Acute Leukemia: International Standardization and Clinical Evaluation. Lucio P, Gaipa G, van Lochem EG, van Wering ER, Porwit-MacDonald A, Faria T, Bjorklund E, Biondi A, van den Beemd MW, Baars E, Vidriales B, Parreira A, van Dongen JJ, San Miguel JF, Orfao A. Leukemia. Aug;15(8):1185-92, 2001 The PML-RARa transcript in long-term follow-up of acute promyelocytic leukemia patients. Gameiro P, Vieira S, Carrara P, Silva AL, Diamond J, de Sousa AB, Mehta AB, Prentice HG, Guimaraes JE, Hoffbrand AV, Foroni L, Parreira A.Haematologica Jun;86(6):577-85, 2001 Autologous peripheral stem cell transplantation for multiple myeloma in a patient with a 10 year-old kidney transplant: case report and clinical issues. Rego F, Alcantara P, Buinho F, Araujo F, Santos JM, Parreira A, da Costa FL.Transplant Proc. 2003 May;35(3):1102-4. Clonality analysis for antigen receptor genes: preliminary results from the Biomed-2 concerted action PL 96-3936. van Krieken JH, Langerak AW, San Miguel JF, Parreira A, Smith JL, Morgan GM, Kneba M, Macintyre EA, van Dongen JJ. Hum Pathol. 2003 Apr;34(4):359-61
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Reports of swine influenza in Mexico and US - an update 25 April 2009 Human cases of swine influenza A (H1N1) virus infection have been identified in California and Texas in the Unites States and in four districts in Mexico. No cases of swine flu have been identified in the UK or anywhere in Europe. The reported events in the US and Mexico are unusual and warrant further investigation and