Curriculum vitae

MAHMOUD ABDEL-RAHMAN SROUR
in Experimental Hematology & Molecular Biology Work address
Private address

Personal Information


Education
PhD degree in Molecular Cell Biology (major) and
Experimental Hematology (minor), with Very good-Plus ( 0.7
out of 5.0); Institute for Cell Biology- Faculty of Science and
Mathematics and Institute for Experimental Haematology &
Transfusion Medicine- Faculty of Medicine; Bonn University,
Bonn, Germany.
The PhD dissertation is entitled: Development of Adenoviral
Vectors for the Expression of Coagulation Factors IX and VIII:
Potential use for Hemophilia Gene Therapy.
The PhD was supported by a scholarship from the German
Academic Exchange Service (DAAD).
MSc degree in Biological Sciences/ Hematology, with excellent
(3.98 out of 4.0); Department of Biological Sciences- Faculty of
Science, University of Jordan, Amman, Jordan.
The MSc thesis is entitled: Evaluation of different methods used
to measure oxidant stress on human erythrocytes.
The MSc was supported by a scholarship from the German
Academic Exchange Service (DAAD).
BSc degree in Medical and Biological Analysis, with excellent
(88 %); Department of Biological Sciences- Faculty of Science,
University of Jordan, Amman, Jordan.
General Secondary School Certificate (Tawjihi), scientific
section, with excellent (94.5 %); Beitunia Secondary School;
Beitunia, Palestine.
Professional Experience
Director of the External Quality Assessment Centre, Faculty of Health Professions, Al-Quds University. Coordinator of the M.Sc. program in Medical Laboratory Sciences, At the Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Assistant Professor of Experimental Hematology & Molecular Cell Biology, At the Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Director of the Molecular Diagnostic Laboratory, Specialized Medical Laboratories, Ramallah Assistant Professor of Experimental Hematology & Molecular Cell Biology, at the Master Program in Medical Laboratory Sciences, Faculty of Science, Birzeit University, Birzeit. Visiting Researcher at the Institute for Experimental Haematology & Transfusion Medicine-Faculty of Medicine; Bonn University, Bonn, Germany. Research points: Development of viral gene transfer systems for gene therapy for hemophilia; Effects of supraphysiological levels of Factor IX in gene therapy studies on the mouse coagulation. Experimental Hematology, At the Biochemistry & Molecular Biology Department, Faculty of Medicine, Al-Quds University, Abu-Dies, Jerusalem. Postdoctoral research work, at the Institute for Experimental Haematology & Transfusion Medicine-Faculty of Medicine; Bonn University, Bonn, Germany. Research areas: bioengineering of human coagulation factor VIII to improve its secretion and production, development of packaging systems for Adenovirus using baculovirus, development of new viral vector (based on Adenovirus and Adeno-associated coagulation factors VIII and IX for use in hemophilia gene therapy. Administrative coordinator, Faculty of Public Health, Al-Quds University, Abu-Dies, Jerusalem. Lecturer, Department of Medical Technology, Faculty of Health Sciences, Al-Quds University, Abu-Dies, Jerusalem. Teaching and Research Assistant, Department of Biological Sciences- Faculty of Science, University of Jordan, Amman, Jordan. Teaching and Research Assistant, Department of Biology and Biochemistry, Birzeit University, Birzeit.
Training courses

Assessment of Medical Laboratories Based on ISO 15189-2007. Organized by Palestine Standard Institution & the German National Metrology Institute, Ramallah, Palestine. Principles And Methods of Evaluation in Higher Education. Organized by the Palestinian Faculty Development Program (PFDP)-AMIDEAST, Bethlehem, Palestine. Quality Assurance in the Clinical Laboratory, 20 hours. Jordanian Society for Clinical Laboratory Sciences, Amman, Jordan. Modern trends in university teaching and learning, 45 hours. Mentorship program, Al-Quds University, Abu-Dies, Palestine. Intensive course in “Biosafety in research laboratories and gene technology legislations”. Institute for Medical Microbiology and Immunology, Faculty of Medicine, Bonn University, Bonn, Germany. “Plant biotechnology and plant tissue culture”. Plant Biotechnology Centre, Bethlehem University, Bethlehem. Training at the different sections of the Medical laboratories at the university of Jordan Hospital and King Hussein Medical Centre, Amman, Jordan.
Other Academic and professional activities

Clinical Laboratory Consultant on Quality Assurance for the “Palestinian Health Sector
Reform and Development Project –Flagship project”. Project was organized and implemented
by USAID & MoH, Ramallah. July-September 2011.
Head of the team that developed the Palestinian National Policy for Blood Transfusion
Services. National Blood Bank, Ramallah, February 2011. The policy was supported by
WHO- Jerusalem Office.
Trainer and coordinator for several workshops in Molecular Diagnostics, Quality control,
Laboratory management and Blood Banking delivered for Clinical laboratory
scientists/technicians. These workshops were supported either by the Palestinian Medical
Technology Association or WHO.
Member of the Organizing Committee and Head of Scientific Committee for the Sixth
Palestinian Conference of Laboratory Medicine, Held at the Al-Quds University – Abu-Dies,
Jerusalem, March 12-13, 2010.
Member of the Organizing Committee and Head of Scientific Committee for the Fifth
Palestinian Conference of Laboratory Medicine, Held at the Arab-American University –
Jenin, March 28-29, 2008.
Elected Member of the Administrative Board and Head of Scientific Committee at the
Palestinian Association for Medical Technology, May 2007 – present.
Elected Member of the Administrative Board and Head of Scientific Committee at the
Palestinian Society for Bleeding Disorders, November 2007 – December 2011.
Publications

Said SS, Srour MA. Hepatitis B virus genotypes and precore/core promoter mutations in
Palestinian patients with chronic HBV and liver complications. (Manuscript in preparation)

Srour MA, Grupp J, Aburubaiha Z, Albert T, Brondke H, Oldenburg J, Schwaab R. Modified
expression of coagulation factor VIII by addition of a glycosylation site at the N-terminus of
the protein. Ann Hematol 2008; 87:107-112.

Srour MA, Fechner H, Wang X, Siemetzki U, Albert T, Oldenburg J, Hanfland P, Poller W,
Brackmann HH, Schwaab R. Regulation of human factor IX expression using doxycycline-
inducible gene expression system. Thromb Haemost 2003; 90(3): 398-405.
Fechner H, Wang X, Srour MA, Siemetzki U, Seltmann H, Sutter AP, Scheruble H, Zoubolis
CC, Schwaab R, Hillen W, Schultheis HP, Poller W. A novel tetracycline-controlled
transactivator-transrepressor system enables external control of oncolytic adenovirus
replication. Gene Ther 2003; 10(19): 1680-90.
Schwaab R, Albert T, Brackmann HH, Srour MA, Oldenburg J. [Gentherapy for
Hemophilia]. Biospektrum 2002; 8(2): 148-152. (In German)
Srour MA, Bilto YY, Juma M. Evaluation of different methods used to measure
malonyldialdehyde in human erythrocytes. Clin Hemorheol Microcirc 2000; 23(1): 23-30.
Srour MA, Bilto YY, Juma M. Susceptibility of erythrocytes from non-insulin-dependent
diabetes mellitus and hemodialysis patients, cigarette smokers and normal subjects to in vitro
oxidative stress and loss of deformability. Clin Hemorheol Microcirc 2000; 22(3): 173-80.
Srour MA, Bilto YY, Juma M, Irhimeh MR. Exposure of human erythrocytes to oxygen
radicals causes loss of deformability, increased osmotic fragility, lipid peroxidation and
protein degradation.Clin Hemorheol Microcirc 2000; 23(1): 13-21.
Essawi T, Srour MA. Screening of some Palestinian medicinal plants for antibacterial
activity. J Ethnopharmacol 2000; 70(3): 343-9.
Research fields and interests
o Genotyping of alpha-globin gene mutations among Palestinian patients with unexplained microcytosis in the West Bank region/ Palestine. o Development of packaging systems (helper virus) for gutless Adenovirus vector (Adenovirus deleted of all viral genes except the packaging signal and inverted terminal repeats) production: potential applications for Hemophilia gene therapy. o Coagulation factor VIII secretion and post-translational modifications. o Molecular genotyping of Hepatitis B virus isolates from HBV chronic patients in West o Improvement of recombinant factor VIII production o Viral vectors for hemophilia gene therapy o Regulation of transgene expression in gene therapy applications o Red cell deformability and oxidative stress o Best Poster Award, awarded on the 12th Arab Medlab & 3rd Lebanese Conference of Clinical Biology, Beirut, Lebanon, October 1-3, 2009. o DAAD short research fellowship, awarded by the German Academic Exchange Service (DAAD), Bonn, Germany, July-August, 2008. o DAAD Scholarship for PhD, awarded by the German Academic Exchange Service (DAAD), Bonn, Germany, October 1999 to November 2003. o DAAD Scholarship for MSc, awarded by the German Academic Exchange Service (DAAD), Bonn, Germany, September 1996 to December 1998. Memberships
o Palestine Medical Technology Association, Ramallah. Since 1995. o Palestinian Society for Bleeding Disorders, Ramallah. Since 2007. o Friends Forum of the German Academic Exchange Service (DAAD), Bonn, Germany. Languages
o Arabic: mother language o English: fluency in written and spoken o German: very good in written and spoken
References

Professor of Experimental Hematology, and leader of the research group” Molecular Biology and Hemophilia Gene Therapy” Molecular Biology Group Institute for Experimental Hematology and Transfusion Medicine Faculty of Medicine- University Clinics, University of Bonn Sigmund-Freud-Str. 25, 53105 Bonn, Germany Tel: +49 (228) 2876742 Email: rainer.schwaab@ukb.uni-bonn.de (First-supervisor of my PhD dissertation) Professor of Hematology and Clinical Chemistry Department of Biological Sciences University of Jordan, Amman, Jordan Tel: +962 (06) 5331501 Email: bilto@ju.edu.jo; bilto@usa.net (First-supervisor of my MSc thesis) Assist. Prof. in Immunology Dean, Faculty of Health Professions Al-Quds University Main Campus, Abu-Dies Jerusalem, Palestine Tel/Fax: +970 2 2799 1243 Email: rabuhelu@med.alquds.edu, rasabu@yahoo.com

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