Standort in Deutschland, wo man günstige und qualitativ hochwertige Kamagra Ohne Rezept Lieferung in jedem Teil der Welt zu kaufen.

Wenn das Problem der Verringerung der Potenz berührt mich persönlich war ich schockiert, dass das passiert gerade mit mir propecia Übrigens jeder leisten und gibt eine sofortige Wirkung ohne Hausarbeiten Anwendungen.

Kidsears.com

Micronase®
glyburide tablets, USP
For Oral Use

DESCRIPTION
MICRONASE Tablets contain glyburide, which is an oral blood-glucose-lowering drug
of the sulfonylurea class. Glyburide is a white, crystalline compound, formulated as
MICRONASE Tablets of 1.25, 2.5, and 5 mg strengths for oral administration. Inactive
ingredients: colloidal silicon dioxide, dibasic calcium phosphate, magnesium stearate,
microcrystalline cellulose, sodium alginate, talc. In addition, the 2.5 mg contains
aluminum oxide and FD&C Red No. 40 and the 5 mg contains aluminum oxide and
FD&C Blue No. 1. The chemical name for glyburide is 1-[ [p-[2-(5-chloro-o-anisamido)-
ethyl]phenyl]-sulfonyl]-3-cyclohexylurea and the molecular weight is 493.99. The
structural formula is represented below.
CLINICAL PHARMACOLOGY
Actions
Glyburide appears to lower the blood glucose acutely by stimulating the release of insulin
from the pancreas, an effect dependent upon functioning beta cells in the pancreatic
islets. The mechanism by which glyburide lowers blood glucose during long-term
administration has not been clearly established. With chronic administration in Type II
diabetic patients, the blood glucose lowering effect persists despite a gradual decline in
the insulin secretory response to the drug. Extrapancreatic effects may be involved in the
mechanism of action of oral sulfonylurea hypoglycemic drugs. The combination of
glyburide and metformin may have a synergistic effect, since both agents act to improve
glucose tolerance by different but complementary mechanisms.
Some patients who are initially responsive to oral hypoglycemic drugs, including MICRONASE, may become unresponsive or poorly responsive over time. Alternatively, MICRONASE Tablets may be effective in some patients who have become unresponsive to one or more other sulfonylurea drugs.
In addition to its blood glucose lowering actions, glyburide produces a mild diuresis by enhancement of renal free water clearance. Disulfiram-like reactions have very rarely been reported in patients treated with MICRONASE Tablets.
Pharmacokinetics
Single dose studies with MICRONASE Tablets in normal subjects demonstrate significant absorption of glyburide within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Mean serum levels of glyburide, as reflected by areas under the serum concentration-time curve, increase in proportion to corresponding increases in dose. Multiple dose studies with MICRONASE in diabetic patients demonstrate drug level concentration-time curves similar to single dose studies, indicating no buildup of drug in tissue depots. The decrease of glyburide in the serum of normal healthy individuals is biphasic; the terminal half-life is about 10 hours. In single dose studies in fasting normal subjects, the degree and duration of blood glucose lowering is proportional to the dose administered and to the area under the drug level concentration-time curve. The blood glucose lowering effect persists for 24 hours following single morning doses in nonfasting diabetic patients. Under conditions of repeated administration in diabetic patients, however, there is no reliable correlation between blood drug levels and fasting blood glucose levels. A one year study of diabetic patients treated with MICRONASE showed no reliable correlation between administered dose and serum drug level.
The major metabolite of glyburide is the 4-transhydroxy derivative. A second metabolite, the 3-cishydroxy derivative, also occurs. These metabolites probably contribute no significant hypoglycemic action in humans since they are only weakly active (1/400th and 1/40th as active, respectively, as glyburide) in rabbits.
Glyburide is excreted as metabolites in the bile and urine, approximately 50% by each route. This dual excretory pathway is qualitatively different from that of other sulfonylureas, which are excreted primarily in the urine.
Sulfonylurea drugs are extensively bound to serum proteins. Displacement from protein binding sites by other drugs may lead to enhanced hypoglycemic action. In vitro, the protein binding exhibited by glyburide is predominantly non-ionic, whereas that of other sulfonylureas (chlorpropamide, tolbutamide, tolazamide) is predominantly ionic. Acidic drugs such as phenylbutazone, warfarin, and salicylates displace the ionic-binding sulfonylureas from serum proteins to a far greater extent than the non-ionic binding glyburide. It has not been shown that this difference in protein binding will result in fewer drug-drug interactions with MICRONASE Tablets in clinical use.
INDICATIONS AND USAGE
MICRONASE is indicated as an adjunct to diet and exercise to improve glycemic control
in adults with type 2 diabetes mellitus.
CONTRAINDICATIONS
MICRONASE Tablets are contraindicated in patients with:
1. Known hypersensitivity or allergy to the drug.
2. Diabetic ketoacidosis, with or without coma. This condition should be treated SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR
MORTALITY
The administration of oral hypoglycemic drugs has been reported to be associated
with increased cardiovascular mortality as compared to treatment with diet alone or
diet plus insulin. This warning is based on the study conducted by the University
Group Diabetes Program (UGDP), a long-term prospective clinical trial designed to
evaluate the effectiveness of glucose-lowering drugs in preventing or delaying
vascular complications in patients with non-insulin-dependent diabetes. The study
involved 823 patients who were randomly assigned to one of four treatment groups

UGDP reported that patients treated for 5 to 8 years with diet plus a fixed dose of
tolbutamide (1.5 grams per day) had a rate of cardiovascular mortality
approximately 2½ times that of patients treated with diet alone. A significant
increase in total mortality was not observed, but the use of tolbutamide was
discontinued based on the increase in cardiovascular mortality, thus limiting the
opportunity for the study to show an increase in overall mortality. Despite
controversy regarding the interpretation of these results, the findings of the UGDP
study provide an adequate basis for this warning. The patient should be informed of
the potential risks and advantages of MICRONASE and of alternative modes of
therapy.

Although only one drug in the sulfonylurea class (tolbutamide) was included in this
study, it is prudent from a safety standpoint to consider that this warning may also
apply to other oral hypoglycemic drugs in this class, in view of their close
similarities in mode of action and chemical structure.

PRECAUTIONS
General
Macrovascular Outcomes: There have been no clinical studies establishing conclusive
evidence of macrovascular risk reduction with MICRONASE or any other anti-diabetic
drug.
Hypoglycemia: All sulfonylureas are capable of producing severe hypoglycemia. Proper patient selection and dosage and instructions are important to avoid hypoglycemic episodes. Renal or hepatic insufficiency may cause elevated drug levels of glyburide and the latter may also diminish gluconeogenic capacity, both of which increase the risk of serious hypoglycemic reactions. Elderly, debilitated or malnourished patients, and those with adrenal or pituitary insufficiency, are particularly susceptible to the hypoglycemic action of glucose-lowering drugs. Hypoglycemia may be difficult to recognize in the elderly and in people who are taking beta-adrenergic blocking drugs. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose lowering drug is used. The risk of hypoglycemia may be increased with combination therapy.
Loss of Control of Blood Glucose: When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection or surgery, a loss of control may occur. At such times it may be necessary to discontinue MICRONASE and administer insulin.
The effectiveness of any hypoglycemic drug, including MICRONASE, in lowering blood glucose to a desired level decreases in many patients over a period of time which may be due to progression of the severity of diabetes or to diminished responsiveness to the drug. This phenomenon is known as secondary failure, to distinguish it from primary failure in which the drug is ineffective in an individual patient when MICRONASE is first given. Adequate adjustment of dose and adherence to diet should be assessed before classifying a patient as a secondary failure.
Hemolytic Anemia: Treatment of patients with glucose 6-phosphate dehydrogenase
(G6PD) deficiency with sulfonylurea agents can lead to hemolytic anemia. Because
MICRONASE b belongs to the class of sulfonylurea agents, caution should be used in
patients with G6PD deficiency and a non-sulfonylurea alternative should be considered.
In post marketing reports, hemolytic anemia has also been reported in patients who did
not have known G6PD deficiency.
Information for Patients: Patients should be informed of the potential risks and advantages of MICRONASE and of alternative modes of therapy. They also should be informed about the importance of adherence to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.
The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure also should be explained.
Physician Counseling Information for Patients: In initiating treatment for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of MICRONASE or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short- term administration of MICRONASE or other antidiabetic medications. Maintenance or discontinuation of MICRONASE or other antidiabetic medications should be based on clinical judgment using regular clinical and laboratory evaluations.
Laboratory Tests
Therapeutic response to MICRONASE Tablets should be monitored by frequent urine
glucose tests and periodic blood glucose tests. Measurement of glycosylated hemoglobin
levels may be helpful in some patients.
Drug Interactions
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including
nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound,
salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase
inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a
patient receiving MICRONASE, the patient should be observed closely for
hypoglycemia. When such drugs are withdrawn from a patient receiving MICRONASE,
the patient should be observed closely for loss of control.
Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving MICRONASE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving MICRONASE, the patient should be observed closely for hypoglycemia.
A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide. The mechanism for this interaction is not known.
A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical or vaginal preparations of miconazole is not known.
Metformin: In a single-dose interaction study in NIDDM subjects, decreases in glyburide AUC and Cmax were observed, but were highly variable. The single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effects, makes the clinical significance of this interaction uncertain. Coadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Studies in rats at doses up to 300 mg/kg/day for 18 months showed no carcinogenic effects. Glyburide is nonmutagenic when studied in the Salmonella microsome test (Ames test) and in the DNA damage/alkaline elution assay. No drug related effects were noted in any of the criteria evaluated in the two year oncogenicity study of glyburide in mice. Pregnancy
Teratogenic Effects: Pregnancy Category B
Reproduction studies have been performed in rats and rabbits at doses up to 500 times the
human dose and have revealed no evidence of impaired fertility or harm to the fetus due
to glyburide. There are, however, no adequate and well controlled studies in pregnant
women. Because animal reproduction studies are not always predictive of human
response, this drug should be used during pregnancy only if clearly needed.
Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many experts recommend that insulin be used during pregnancy to maintain blood glucose as close to normal as possible.
Nonteratogenic Effects: Prolonged severe hypoglycemia (4 to 10 days) has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. If MICRONASE is used during pregnancy, it should be discontinued at least two weeks before the expected delivery date.
Nursing Mothers
Although it is not known whether glyburide is excreted in human milk, some
sulfonylurea drugs are known to be excreted in human milk. Because the potential for
hypoglycemia in nursing infants may exist, a decision should be made whether to
discontinue nursing or to discontinue the drug, taking into account the importance of the
drug to the mother. If the drug is discontinued, and if diet alone is inadequate for
controlling blood glucose, insulin therapy should be considered.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Geriatric Use
Elderly patients are particularly susceptible to the hypoglycemic action of glucose
lowering drugs. Hypoglycemia may be difficult to recognize in the elderly (see
PRECAUTIONS). The initial and maintenance dosing should be conservative to avoid
hypoglycemic reactions (see DOSAGE AND ADMINISTRATION).
Elderly patients are prone to develop renal insufficiency, which may put them at risk of hypoglycemia. Dose selection should include assessment of renal function.
ADVERSE REACTIONS
Hypoglycemia: See Precautions and Overdosage Sections.
Gastrointestinal Reactions: Cholestatic jaundice and hepatitis may occur rarely
which may progress to liver failure; MICRONASE Tablets should be discontinued if this
occurs.
Liver function abnormalities, including isolated transaminase elevations, have been reported.
Gastrointestinal disturbances, eg, nausea, epigastric fullness, and heartburn are the most common reactions, having occurred in 1.8% of treated patients during clinical trials. They tend to be dose related and may disappear when dosage is reduced.
Dermatologic Reactions: Allergic skin reactions, eg, pruritus, erythema, urticaria,
and morbilliform or maculopapular eruptions occurred in 1.5% of treated patients during
clinical trials. These may be transient and may disappear despite continued use of
MICRONASE; if skin reactions persist, the drug should be discontinued.
Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.
Hematologic Reactions: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic
anemia (see PRECAUTIONS), aplastic anemia, and pancytopenia have been reported
with sulfonylureas.
Metabolic Reactions: Hepatic porphyria and disulfiram-like reactions have been
reported with sulfonylureas; however, hepatic porphyria has not been reported with
MICRONASE and disulfiram-like reactions have been reported very rarely.
Cases of hyponatremia have been reported with glyburide and all other sulfonylureas, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or increase release of antidiuretic hormone. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with certain other sulfonylureas, and it has been suggested that these sulfonylureas may augment the peripheral (antidiuretic) action of ADH and/or increase release of ADH.
Other Reactions: Changes in accommodation and/or blurred vision have been reported
with glyburide and other sulfonylureas. These are thought to be related to fluctuation in
glucose levels.
In addition to dermatologic reactions, allergic reactions such as angioedema, arthralgia, myalgia and vasculitis have been reported.
OVERDOSAGE
Overdosage of sulfonylureas, including MICRONASE Tablets, can produce
hypoglycemia. Mild hypoglycemic symptoms, without loss of consciousness or
neurological findings, should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate which will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery.
DOSAGE AND ADMINISTRATION
There is no fixed dosage regimen for the management of diabetes mellitus with
MICRONASE Tablets or any other hypoglycemic agent. In addition to the usual
monitoring of urinary glucose, the patient’s blood glucose must also be monitored
periodically to determine the minimum effective dose for the patient; to detect primary
failure, ie, inadequate lowering of blood glucose at the maximum recommended dose of
medication; and to detect secondary failure, ie, loss of adequate blood glucose lowering
response after an initial period of effectiveness. Glycosylated hemoglobin levels may also
be of value in monitoring the patient’s response to therapy.
Short-term administration of MICRONASE may be sufficient during periods of transient loss of control in patients usually controlled well on diet.
Usual Starting Dose
The usual starting dose of MICRONASE Tablets is 2.5 to 5 mg daily, administered with
breakfast or the first main meal. Those patients who may be more sensitive to
hypoglycemic drugs should be started at 1.25 mg daily. (See PRECAUTIONS section for
patients at increased risk.) Failure to follow an appropriate dosage regimen may
precipitate hypoglycemia. Patients who do not adhere to their prescribed dietary and drug
regimen are more prone to exhibit unsatisfactory response to therapy.
Transfer From Other Hypoglycemic Therapy Patients Receiving Other Oral Antidiabetic Therapy: Transfer of patients from other oral antidiabetic regimens to MICRONASE should be done conservatively and the initial daily dose should be 2.5 to 5 mg. When transferring patients from oral hypoglycemic agents other than chlorpropamide to MICRONASE, no transition period and no initial or priming dose are necessary. When transferring patients from chlorpropamide, particular care should be exercised during the first two weeks because the prolonged retention of chlorpropamide in the body and subsequent overlapping drug effects may provoke hypoglycemia.
Patients Receiving Insulin: Some Type II diabetic patients being treated with insulin may respond satisfactorily to MICRONASE. If the insulin dose is less than 20 units daily, substitution of MICRONASE Tablets 2.5 to 5 mg as a single daily dose may be tried. If the insulin dose is between 20 and 40 units daily, the patient may be placed directly on MICRONASE Tablets 5 mg daily as a single dose. If the insulin dose is more than 40 units daily, a transition period is required for conversion to MICRONASE. In these patients, insulin dosage is decreased by 50% and MICRONASE Tablets 5 mg daily is started. Please refer to Titration to Maintenance Dose for further explanation.
Titration to Maintenance Dose
The usual maintenance dose is in the range of 1.25 to 20 mg daily, which may be given as
a single dose or in divided doses (See Dosage Interval section). Dosage increases should
be made in increments of no more than 2.5 mg at weekly intervals based upon the
patient’s blood glucose response.
No exact dosage relationship exists between MICRONASE and the other oral hypoglycemic agents. Although patients may be transferred from the maximum dose of other sulfonylureas, the maximum starting dose of 5 mg of MICRONASE Tablets should be observed. A maintenance dose of 5 mg of MICRONASE Tablets provides approximately the same degree of blood glucose control as 250 to 375 mg chlorpropamide, 250 to 375 mg tolazamide, 500 to 750 mg acetohexamide, or 1000 to 1500 mg tolbutamide.
When transferring patients receiving more than 40 units of insulin daily, they may be started on a daily dose of MICRONASE Tablets 5 mg concomitantly with a 50% reduction in insulin dose. Progressive withdrawal of insulin and increase of MICRONASE in increments of 1.25 to 2.5 mg every 2 to 10 days is then carried out. During this conversion period when both insulin and MICRONASE are being used, hypoglycemia may rarely occur. During insulin withdrawal, patients should test their urine for glucose and acetone at least three times daily and report results to their physician. The appearance of persistent acetonuria with glycosuria indicates that the patient is a Type I diabetic who requires insulin therapy.
Concomitant Glyburide and Metformin Therapy
MICRONASE Tablets should be added gradually to the dosing regimen of patients who
have not responded to the maximum dose of metformin monotherapy after four weeks
(see Usual Starting Dose and Titration to Maintenance Dose). Refer to metformin
package insert.
With concomitant glyburide and metformin therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. However, attempts should be made to identify the optimal dose of each drug needed to achieve this goal. With concomitant glyburide and metformin therapy, the risk of hypoglycemia associated with sulfonylurea therapy continues and may be increased. Appropriate precautions should be taken (see PRECAUTIONS section).
Maximum Dose
Daily doses of more than 20 mg are not recommended.
Dosage Interval
Once-a-day therapy is usually satisfactory. Some patients, particularly those receiving more than 10 mg daily, may have a more satisfactory response with twice-a-day dosage.
Specific Patient Populations
MICRONASE is not recommended for use in pregnancy or for use in pediatric patients.
In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function, the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. (See PRECAUTIONS section.) HOW SUPPLIED
MICRONASE Tablets are supplied as follows:
MICRONASE Tablets 1.25 mg (White, Round, Scored, imprinted MICRONASE 1.25)
MICRONASE Tablets 2.5 mg (Dark Pink, Round, Scored, imprinted MICRONASE
2.5)
MICRONASE Tablets 5 mg (Blue, Round, Scored imprinted MICRONASE 5)
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Dispensed in well closed containers with safety closures. Keep container tightly closed.

Source: http://www.kidsears.com/files/products/uspi_micronase.pdf

Laser_co2_frazionale

C H I R U R G I A P L A S T I C A R I C O S T R U T T I V A LASER CO2 FRAZIONALE ABLATIVO Questo documento di consenso informato è stato preparato per informarLa circa il trattamento con laser CO2 frazionale, i possibili risultati, i suoi rischi ed i trattamenti alternativi. E 'importante leggere completamente e attentamente queste informazioni. Si prega di siglare ogni pagina con le pro

Etica organizacional

ETICA ORGANIZACIONAL Marcelo Briola (Universidad de Buenos Aires) El individuo, la organización y la sociedad están altamente relacionados, el debate actual tiene como finalidad el análisis de las ventajas y desventajas que se ponen de manifiesto en la organización y su impacto en la sociedad. Este trabajo refiere a la ética organizacional y será muestra con el inicio de un panorama

Copyright © 2010-2014 Internet pdf articles